ChemicalBook > CAS DataBase List > 5-Amino-2-nitrobenzoic acid

5-Amino-2-nitrobenzoic acid

Product Name
5-Amino-2-nitrobenzoic acid
CAS No.
13280-60-9
Chemical Name
5-Amino-2-nitrobenzoic acid
Synonyms
ANBA;NSC 74455;TIMTEC-BB SBB008583;3-CARBOXY-4-NITROANILINE;(Purified) [for gamma-GT];5-Amino-2-nitrobenzoicaci;3-AMINO-6-NITROBENZOIC ACID;5-AMINO-2-NITROBENZOIC ACID;2-NITRO-5-AMINOBENZOIC ACID;Benzoic acid, 5-amino-2-nitro-
CBNumber
CB1738500
Molecular Formula
C7H6N2O4
Formula Weight
182.13
MOL File
13280-60-9.mol
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5-Amino-2-nitrobenzoic acid Property

Melting point:
236-238 °C (lit.)
Boiling point:
481.3±35.0 °C(Predicted)
Density 
1.568±0.06 g/cm3(Predicted)
vapor pressure 
0-0Pa at 20-50℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO, Methanol
pka
2.28±0.25(Predicted)
form 
Solid
color 
Yellow-Brown
Water Solubility 
Insoluble
BRN 
2107512
InChIKey
KZZWQCKYLNIOBT-UHFFFAOYSA-N
LogP
-1.48 at pH7
Surface tension
70.53mN/m at 1g/L and 20℃
CAS DataBase Reference
13280-60-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22-20/21/22
Safety Statements 
26-36/37/39-37/39-36
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
564613
Product name
5-Amino-2-nitrobenzoic acid
Purity
97%
Packaging
5g
Price
$58.4
Updated
2024/03/01
TCI Chemical
Product number
A0897
Product name
5-Amino-2-nitrobenzoic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$72
Updated
2024/03/01
TCI Chemical
Product number
A0897
Product name
5-Amino-2-nitrobenzoic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$254
Updated
2024/03/01
Alfa Aesar
Product number
L16225
Product name
5-Amino-2-nitrobenzoic acid, 95%
Packaging
5g
Price
$92.3
Updated
2024/03/01
Alfa Aesar
Product number
L16225
Product name
5-Amino-2-nitrobenzoic acid, 95%
Packaging
1g
Price
$29.8
Updated
2021/12/16
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5-Amino-2-nitrobenzoic acid Chemical Properties,Usage,Production

Description

5-Amino-2-nitrobenzoic acid is a reagent used in preparation of polymer-bound diazonium salts and insulin receptor tyrosine kinase activator. It is also used in 2-component dendritic chain reactions and activation of hydrophobic dendrimers.

Chemical Properties

5-Amino-2-nitrobenzoic acid appears as a yellow powder or crystal. Its crystal structure is: the 5-amino-2-nitrobenzoic acid crystallizes in the monoclinic P21/c space group with a = 3.898(2)?, b = 13.531(3)?, c = 14.301(3) ?, and β = 90.83(3)?. The adjacent molecules form a cyclic dimmer by intermolecular hydrogen bonds of type O H···O with their carboxyl groups. In the crystal structure NH2 group forms a threecenter hydrogen bond with oxygen atoms of NO2 group.

Uses

5-Amino-2-nitrobenzoic acid can be used as a standard for the determination of γ-GT activity using 5-amino-2-nitrobenzoic acid as a standard. 5-Amino-2-nitrobenzoic acid (ANB) can also be used for spectroscopic studies by determining the FTIR and FT-Raman spectra of ANB in the 400-4000 cm-1 range and calculating the theoretically constructed spectra in good agreement with the experimental spectra.

Uses

Reactant for:

  • Two-component dendritic chain reactions
  • Enzymic activation of hydrophobic self-immolative dendrimers
  • Preparation of insulin receptor tyrosine kinase activator
  • Preparation of polymer-bound diazonium salts using Merrifield resin-bound piperazine

Application

5-Amino-2-nitrobenzoic acid is a drug that has been shown to inhibit the activity of proteases. It has been used to detect the presence of protease activity in urine samples, as well as to study the inhibition of protease activity by other drugs. It is an inhibitor of chymotrypsin, trypsin, and elastase. This drug has been shown to be effective in inhibiting these enzymes at low concentrations, with a detection sensitivity of approximately 0.1 μM. It inhibits the growth of bacteria by binding to them and preventing protein synthesis. The compound also inhibits the enzyme dihydrolipoamide dehydrogenase in mitochondria, which is required for cellular respiration and energy production.

Purification Methods

Crystallise the acid from water. [Beilstein 14 III 1021.]

5-Amino-2-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

4'-Nitroacetanilide

Preparation Products

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5-Amino-2-nitrobenzoic acid Suppliers

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View Lastest Price from 5-Amino-2-nitrobenzoic acid manufacturers

Hpets Biotech Company (Chongqing) Co.,ltd
Product
5-Amino-2-nitrobenzoic acid 13280-60-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-03-21
Hebei Duling International Trade Co. LTD
Product
5-Amino-2-nitrobenzoic acid 13280-60-9
Price
US $34.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-03-08
Career Henan Chemical Co
Product
5-Amino-2-nitrobenzoic acid 13280-60-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

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