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2-AMINO-5-CHLORO-3-IODOPYRIDINE

Product Name
2-AMINO-5-CHLORO-3-IODOPYRIDINE
CAS No.
211308-81-5
Chemical Name
2-AMINO-5-CHLORO-3-IODOPYRIDINE
Synonyms
5-Chloro-3-iodopyridin-2-amine;5-chloro-3-iodo-2-pyridinamine;2-AMINO-5-CHLORO-4-IODOPYRIDINE;2-AMINO-5-CHLORO-3-IODOPYRIDINE;2-amino-3-iodo-5-chloropyridine;2-PyridinaMine, 5-chloro-3-iodo-;5-CHLORO-3-IODO-PYRIDIN-2-YLAMINE;2-AMINO-5-CHLORO-3-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber
CB1750449
Molecular Formula
C5H4ClIN2
Formula Weight
254.46
MOL File
211308-81-5.mol
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2-AMINO-5-CHLORO-3-IODOPYRIDINE Property

Melting point:
137-138°C
Boiling point:
306.9±42.0 °C(Predicted)
Density 
2.139±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder to crystal
pka
2.27±0.49(Predicted)
color 
Light yellow to Yellow to Orange
Sensitive 
Light Sensitive
CAS DataBase Reference
211308-81-5
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000363
Product name
5-Chloro-3-iodo-pyridin-2-ylamine
Purity
Aldrich
Packaging
1g
Price
$482
Updated
2024/03/01
TCI Chemical
Product number
A3069
Product name
2-Amino-5-chloro-3-iodopyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$77
Updated
2025/07/31
TCI Chemical
Product number
A3069
Product name
2-Amino-5-chloro-3-iodopyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$231
Updated
2025/07/31
TRC
Product number
A603215
Product name
2-Amino-5-chloro-3-iodopyridine
Packaging
1g
Price
$140
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-M-05
Product name
2-Amino-5-chloro-3-iodopyridine
Packaging
5G
Price
$96
Updated
2021/12/16
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2-AMINO-5-CHLORO-3-IODOPYRIDINE Chemical Properties,Usage,Production

Uses

2-Amino-5-chloro-3-iodopyridine is a useful synthetic intermediate. It was used in the rational design of highly selective spleen tyrosine kinase inhibitors. It was also used to synthesize azaindole derivatives with antibacterial and antifungal activities.

Synthesis

1072-98-6

211308-81-5

GENERAL STEPS: 24,150 mL of a solvent mixture of tetrahydrofuran and 50 L of ethylene dichloride were added to an 8000 mL reactor, a plug-in thermometer was installed and a mechanical stirrer was started. Subsequently, 6037.5 g of 2-amino-5-chloropyridine and 18528 g of N-iodosuccinimide were added to the reactor. The reaction mixture was stirred continuously at 53 °C for 7 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and gas chromatography (GC) to confirm the complete reaction of 2-amino-5-chloropyridine. Upon completion of the reaction, the solvent was removed using a rotary evaporator to give the crude product. The crude product was recrystallized by a solvent mixture of ethyl acetate and ethanol to obtain purified 2-amino-3-iodo-5-chloropyridine. The product was dried and the calculated yield was 90.10% and the purity was 98.2% by GC.

References

[1] Patent: CN104744353, 2017, B. Location in patent: Paragraph 0017-0031
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 2, p. 307 - 315
[3] Patent: US2014/18533, 2014, A1. Location in patent: Paragraph 0074; 0075
[4] Patent: WO2011/73263, 2011, A1. Location in patent: Page/Page column 88-89
[5] Patent: WO2005/95400, 2005, A1. Location in patent: Page/Page column 345-346

2-AMINO-5-CHLORO-3-IODOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-CHLORO-3-IODOPYRIDINE Suppliers

Americas 1 China 118 Europe 1 France 2 Germany 1 India 7 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 30 Global 170
P&S Chemicals
Tel
--
Fax
--
Email
info@pschemicals.com
Country
The Netherlands
ProdList
2724
Advantage
58
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View Lastest Price from 2-AMINO-5-CHLORO-3-IODOPYRIDINE manufacturers

Dideu Industries Group Limited
Product
2-AMINO-5-CHLORO-3-IODOPYRIDINE 211308-81-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01
Career Henan Chemical Co
Product
2-AMINO-5-CHLORO-3-IODOPYRIDINE 211308-81-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-20

211308-81-5, 2-AMINO-5-CHLORO-3-IODOPYRIDINERelated Search:

2-Amino-3-bromo-5-chloropyridine 2-AMINO-3-CHLORO-5-FLUOROPYRIDINE 2-Amino-3-bromo-5-fluoropyridine 3-BROMO-5-IODOPYRIDIN-2-AMINE 3,5-Dibromo-2-pyridylamine 2-Amino-3,5-dichloropyridine 5-Bromo-2-chloropyridine-3-carboxamide 2-AMINO-3-CHLORO-5-BROMOPYRIDINE 2-AMINO-5-BROMO-3-IODOPYRIDINE 3-Iodopyridine 4-Iodopyridine 2-AMINO-5-CHLORO-3-IODOPYRIDINE 3-Iodopyridin-2-amine 5-CHLORO-3-IODOPYRIDIN-2-YLHYDRAZINE 3-CHLORO-5-IODO-PYRIDINE 2-AMINO-3-IODO-5-CHLORO-6-METHYLPYRIDINE 3-AMINO-2-CHLORO-5-IODOPYRIDINE 3-Amino-2-chloro-6-iodopyridine,3-Amino-6-chloro-2-iodopyridine

  • 2-AMINO-5-CHLORO-3-IODOPYRIDINE
  • 5-CHLORO-3-IODO-PYRIDIN-2-YLAMINE
  • 2-AMINO-5-CHLORO-4-IODOPYRIDINE
  • 5-chloro-3-iodo-2-pyridinamine
  • 5-Chloro-3-iodopyridin-2-amine
  • 2-PyridinaMine, 5-chloro-3-iodo-
  • 2-amino-3-iodo-5-chloropyridine
  • 2-AMINO-5-CHLORO-3-IODOPYRIDINE ISO 9001：2015 REACH
  • 211308-81-5