5-Bromo-2-nitropyridine
- Product Name
- 5-Bromo-2-nitropyridine
- CAS No.
- 39856-50-3
- Chemical Name
- 5-Bromo-2-nitropyridine
- Synonyms
- 2-NITRO-5-BROMOPYRIDINE;AKOS BBS-00001330;5-Bromo-2-nitropyrid;Risdiplam Impurity 8;3-BROMO-6-NITROPYRIDINE;5-BROMO-2-NITROPYRIDINE;5-Bromo-2-notropyridine;2-Nitro-5-borMopyridine;Palbociclib impurity A;Pyridine, 5-broMo-2-nitro-
- CBNumber
- CB1773370
- Molecular Formula
- C5H3BrN2O2
- Formula Weight
- 202.99
- MOL File
- 39856-50-3.mol
5-Bromo-2-nitropyridine Property
- Melting point:
- 148-150 °C (lit.)
- Boiling point:
- 292.3±20.0 °C(Predicted)
- Density
- 1.833±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -4.95±0.22(Predicted)
- color
- White to yellow to beige powder or crystal or chunks
- BRN
- 120878
- InChI
- InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
- InChIKey
- ATXXLNCPVSUCNK-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=NC=C(Br)C=C1
- CAS DataBase Reference
- 39856-50-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 520411
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- 99%
- Packaging
- 5g
- Price
- $48.78
- Updated
- 2025/07/31
- Product number
- B2766
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- B2766
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- B686180
- Product name
- 5-Bromo-2-nitropyridine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 021038
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $11
- Updated
- 2021/12/16
5-Bromo-2-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless solid
Uses
5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.
Preparation
5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].
Synthesis Reference(s)
[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.
Synthesis
1072-97-5
39856-50-3
General steps for the synthesis of 5-bromo-2-nitropyridine from 2-amino-5-bromopyridine: Add 500L of glacial acetic acid and 150L of acetic acid in a 1000L autoclave, turn on the stirring and circulate the cooling water. When the mixture is homogeneous, slowly add 120 kg of 2-amino-5-bromopyridine and control the temperature at 20℃. After stirring for 30 minutes, 300 kg of peroxyacetic acid was slowly added dropwise. When the dropwise addition to the remaining about 50kg, observed that the temperature began to rise slowly, at this time to suspend the dropwise addition. After the temperature stabilized and stopped rising, the remaining peroxyacetic acid was added dropwise, and the temperature was kept at 30℃ throughout the process. After the dropwise addition was completed, the temperature was raised to 40°C and the reaction was kept at a constant temperature for 20 hours. After the reaction was completed, distillation was carried out under reduced pressure, and the distillation was stopped after about 600 L of acetic acid was evaporated. The remaining liquid was cooled to 25 °C, diluted by adding 500 L of water, and the pH was adjusted with 40% sodium hydroxide solution to 8. Subsequently, the mixture was cooled to -20 °C, filtered and dried to give 125 kg of crude product in 89.3% yield. After recrystallization, 120.5 kg of pure product was obtained in 86.1% yield.
References
[1] Patent: CN106187867, 2016, A. Location in patent: Paragraph 0035; 0044; 0045
[2] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 3, p. 467 - 479
[3] Patent: CN108558745, 2018, A. Location in patent: Paragraph 0023; 0024; 0025; 0026
[4] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 113
[5] Journal of Organic Chemistry, 2008, vol. 73, # 23, p. 9326 - 9333
5-Bromo-2-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-2-nitropyridine manufacturers
- Product
- 5-Bromo-2-nitropyridine 39856-50-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-30
- Product
- 5-Bromo-2-nitropyridine 39856-50-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-19
- Product
- 5-Bromo-2-nitropyridine 39856-50-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29