ChemicalBook > CAS DataBase List > 5-Bromo-2-nitropyridine

5-Bromo-2-nitropyridine

Product Name
5-Bromo-2-nitropyridine
CAS No.
39856-50-3
Chemical Name
5-Bromo-2-nitropyridine
Synonyms
2-NITRO-5-BROMOPYRIDINE;AKOS BBS-00001330;5-Bromo-2-nitropyrid;3-BROMO-6-NITROPYRIDINE;5-BROMO-2-NITROPYRIDINE;5-Bromo-2-notropyridine;2-Nitro-5-borMopyridine;Palbociclib impurity A;Pyridine, 5-broMo-2-nitro-;5-Bromo-2-nitropyridine 99%
CBNumber
CB1773370
Molecular Formula
C5H3BrN2O2
Formula Weight
202.99
MOL File
39856-50-3.mol
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5-Bromo-2-nitropyridine Property

Melting point:
148-150 °C (lit.)
Boiling point:
292.3±20.0 °C(Predicted)
Density 
1.833±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
-4.95±0.22(Predicted)
color 
White to yellow to beige powder or crystal or chunks
BRN 
120878
InChI
InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
InChIKey
ATXXLNCPVSUCNK-UHFFFAOYSA-N
SMILES
C1([N+]([O-])=O)=NC=C(Br)C=C1
CAS DataBase Reference
39856-50-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
520411
Product name
5-Bromo-2-nitropyridine
Purity
99%
Packaging
5g
Price
$23.76
Updated
2024/03/01
TCI Chemical
Product number
B2766
Product name
5-Bromo-2-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
B2766
Product name
5-Bromo-2-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$57
Updated
2024/03/01
Alfa Aesar
Product number
L19748
Product name
5-Bromo-2-nitropyridine, 98+%
Packaging
5g
Price
$90.65
Updated
2024/03/01
Alfa Aesar
Product number
L19748
Product name
5-Bromo-2-nitropyridine, 98+%
Packaging
1g
Price
$30.6
Updated
2021/12/16
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5-Bromo-2-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Colorless solid

Uses

5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.

Preparation

5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].

Synthesis Reference(s)

[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.

5-Bromo-2-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Bromo-2-nitropyridine manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
5-Bromo-2-nitropyridine 39856-50-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-05-14
Hong Kong Excellence Biotechnology Co., Ltd.
Product
5-Bromo-2-nitropyridine 39856-50-3
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12
Shanghai Aosiris new Material Technology Co., LTD
Product
5-Bromo-2-nitropyridine 39856-50-3
Price
US $3.00-1.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10 tons
Release date
2024-04-16

39856-50-3, 5-Bromo-2-nitropyridineRelated Search:


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  • 39856-50-3