5-Bromo-2-nitropyridine
- Product Name
- 5-Bromo-2-nitropyridine
- CAS No.
- 39856-50-3
- Chemical Name
- 5-Bromo-2-nitropyridine
- Synonyms
- 2-NITRO-5-BROMOPYRIDINE;AKOS BBS-00001330;5-Bromo-2-nitropyrid;3-BROMO-6-NITROPYRIDINE;5-BROMO-2-NITROPYRIDINE;5-Bromo-2-notropyridine;2-Nitro-5-borMopyridine;Palbociclib impurity A;Pyridine, 5-broMo-2-nitro-;5-Bromo-2-nitropyridine 99%
- CBNumber
- CB1773370
- Molecular Formula
- C5H3BrN2O2
- Formula Weight
- 202.99
- MOL File
- 39856-50-3.mol
5-Bromo-2-nitropyridine Property
- Melting point:
- 148-150 °C (lit.)
- Boiling point:
- 292.3±20.0 °C(Predicted)
- Density
- 1.833±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -4.95±0.22(Predicted)
- color
- White to yellow to beige powder or crystal or chunks
- BRN
- 120878
- InChI
- InChI=1S/C5H3BrN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
- InChIKey
- ATXXLNCPVSUCNK-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=NC=C(Br)C=C1
- CAS DataBase Reference
- 39856-50-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 520411
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- 99%
- Packaging
- 5g
- Price
- $23.76
- Updated
- 2024/03/01
- Product number
- B2766
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $20
- Updated
- 2024/03/01
- Product number
- B2766
- Product name
- 5-Bromo-2-nitropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $57
- Updated
- 2024/03/01
- Product number
- L19748
- Product name
- 5-Bromo-2-nitropyridine, 98+%
- Packaging
- 5g
- Price
- $90.65
- Updated
- 2024/03/01
- Product number
- L19748
- Product name
- 5-Bromo-2-nitropyridine, 98+%
- Packaging
- 1g
- Price
- $30.6
- Updated
- 2021/12/16
5-Bromo-2-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless solid
Uses
5-Bromo-2-nitropyridine is employed as a reagent in the synthesis of novel benzinidazoles, potent inhibitors of TIE-2 and VEGFR-2 Tyrosine (T899975) kinase receptors.
Preparation
5-Bromo-2-nitropyridine was prepared from the corresponding amine via hydrogen peroxide oxidation in large scale production. N-Bromosuccinimide (NBS) bromination of 2-aminopyridine in acetonitrile at 0-5 °C delivered 5-bromo-2- aminopyridine with good regioselectivity (>20:1). The brominated amino-pyridine was then reacted with the oxidant mixture, yielding 5-Bromo-2-nitropyridine after dilution with water and isopropanol[1].
Synthesis Reference(s)
[1] Agosti, Alessandro, et al. "Handling Hydrogen Peroxide Oxidations on a Large Scale: Synthesis of 5-Bromo-2-nitropyridine." Organic Process Research & Development 21.3(2017):451-459.
5-Bromo-2-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-2-nitropyridine Suppliers
- Tel
- --
- Fax
- --
- info@ncc.ie
- Country
- Ireland
- ProdList
- 302
- Advantage
- 58
View Lastest Price from 5-Bromo-2-nitropyridine manufacturers
- Product
- 5-Bromo-2-nitropyridine 39856-50-3
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-05-14
- Product
- 5-Bromo-2-nitropyridine 39856-50-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-19
- Product
- 5-Bromo-2-nitropyridine 39856-50-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-30