ChemicalBook > CAS DataBase List > 1,4-Bis(diphenylphosphino)butane

1,4-Bis(diphenylphosphino)butane

Product Name
1,4-Bis(diphenylphosphino)butane
CAS No.
7688-25-7
Chemical Name
1,4-Bis(diphenylphosphino)butane
Synonyms
DPPB;1,4-di(diphenylphosphino)-butane;[4-(Diphenylphosphino)butyl](diphenyl)phosphine;1,4-Bis(diphenylphosphanyl)butane;TETRAMETHYLENEBIS(DIPHENYLPHOSPHINE);1,4-B;98% DPPB;1,4-Bis(diphenylphos;1,4-BIS(DIPHENYPHOSPHINO);Bis(1,4-diphenylphosphino
CBNumber
CB1774195
Molecular Formula
C28H28P2
Formula Weight
426.47
MOL File
7688-25-7.mol
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1,4-Bis(diphenylphosphino)butane Property

Melting point:
132-136 °C (lit.)
Boiling point:
542.0±33.0 °C(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
Crystalline Powder
color 
White to almost white
Water Solubility 
Soluble in chloroform. Slightly soluble in water
BRN 
706446
InChI
InChI=1S/C28H28P2/c1-5-15-25(16-6-1)29(26-17-7-2-8-18-26)23-13-14-24-30(27-19-9-3-10-20-27)28-21-11-4-12-22-28/h1-12,15-22H,13-14,23-24H2
InChIKey
BCJVBDBJSMFBRW-UHFFFAOYSA-N
SMILES
P(CCCCP(C1C=CC=CC=1)C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1
CAS DataBase Reference
7688-25-7(CAS DataBase Reference)
NIST Chemistry Reference
1,4-Bis(diphenylphosphino)butane(7688-25-7)
EPA Substance Registry System
Phosphine, 1,4-butanediylbis[diphenyl- (7688-25-7)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/38-36/37/38-11
Safety Statements 
26-36-37/39-33-16-7/9
WGK Germany 
3
F 
10-23
TSCA 
Yes
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
261947
Product name
1,4-Bis(diphenylphosphino)butane
Purity
98%
Packaging
5g
Price
$45.51
Updated
2025/07/31
Sigma-Aldrich
Product number
261947
Product name
1,4-Bis(diphenylphosphino)butane
Purity
98%
Packaging
25g
Price
$93.6
Updated
2025/07/31
TCI Chemical
Product number
B1246
Product name
1,4-Bis(diphenylphosphino)butane
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
B1246
Product name
1,4-Bis(diphenylphosphino)butane
Purity
>98.0%(GC)
Packaging
25g
Price
$114
Updated
2025/07/31
Strem Chemicals
Product number
15-0170
Product name
1,4-Bis(diphenylphosphino)butane, 98% DPPB
Packaging
2g
Price
$38
Updated
2024/03/01
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1,4-Bis(diphenylphosphino)butane Chemical Properties,Usage,Production

Chemical Properties

1,4-Bis(diphenylphosphino)butane is a white solid that is soluble in organic solvents.

Uses

1,4-Bis(diphenylphosphino)butane is used in Suzuki reaction. It plays an essential role as a ligand in palladium(0)-catalyzed acylcyanation of arylacetylenes and deprotection of allyloxycarbamates. It acts as a ligand for alkylations, isomerization reactions and in organometallic chemistry. Further, it is used in Heck reaction, Negishi coupling and Sonogashira coupling. In addition to this, it is useful in organometallic chemistry.

reaction suitability

reagent type: ligand
reaction type: Alkylations
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Isomerizations
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Sonogashira Coupling
reagent type: ligand
reaction type: Stille Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

storage

Readily oxidized in solution to the phosphine oxide and should be handled under N2 or Ar. The compound is air-stable in the solid state.

Purification Methods

Recrystallise it from EtOH [Trippett J Chem Soc 4263 1961]. [King J Coord Chem 1 62 1971, Tolman Chem Rev 77 313 1977.]

1,4-Bis(diphenylphosphino)butane Preparation Products And Raw materials

Raw materials

Diphenylphosphine Ethanol Acetone 1,4-Dichlorobutane Sodium Tetrahydrofuran Ethyl acetate Hydrochloric acid 1,4-Dibromobutane Dichloromethane Sodium hydroxide Triphenylphosphine Magnesium sulfate Lithium n-Butyllithium

Preparation Products

(S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97% (R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (R)-(+)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE
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1,4-Bis(diphenylphosphino)butane Suppliers

Americas 1 Belgium 1 Canada 1 China 349 Europe 3 France 2 Germany 5 India 14 Japan 7 Russia 1 South Korea 1 Switzerland 3 Ukraine 2 United Kingdom 15 United States 46 Global 451
Henan Research New Material Co., Ltd.
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View Lastest Price from 1,4-Bis(diphenylphosphino)butane manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1,4-Bis(diphenylphosphino)butane 7688-25-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-02
Henan Research New Materials Co., Ltd.
Product
1,4-Bis(diphenylphosphino)butane 7688-25-7
Price
US $0.00/Kg
Min. Order
1Kg
Purity
99％；sales036@researchvip.com;18903931628;
Supply Ability
100kg
Release date
2024-11-23
Henan Aochuang Chemical Co.,Ltd.
Product
1,4-Bis(diphenylphosphino)butane 7688-25-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27

7688-25-7, 1,4-Bis(diphenylphosphino)butaneRelated Search:

N-(Carboxymethyl)-N-(phosphonomethyl)-glycine 1,3-Diphenyl-2-thiourea Dichlorodiphenylsilane Chlorodiphenylphosphine Diphenylphosphine oxide 1,3-Bis(diphenylphosphino)propane (2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine (2S,4S)-4-Diphenylphosphino 2-diphenylphosphinomethyl pyrrolidine TETRAMETHYLENEBIS(TRIPHENYLPHOSPHONIUM BROMIDE) (-)-DIOP (+)-DIOP 1,4-Bis(diphenylphosphino)butane-palladium(II) chloride (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE,(2R,3R)-(+)-Bis(diphenylphosphino)butane, (R,R)-CHIRAPHOS (2S,3S)-(-)-BIS(DIPHENYLPHOSPHINO)BUTANE Phenyl phosphine Diphenylphosphine (1R,2R)-(-)-1,2-BIS(DIPHENYLPHOSPHINOMETHYL)CYCLOHEXANE (2R,5R)-(+)-BIS(DIPHENYLPHOSPHINO)HEXANE

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  • 7688-25-7
  • C28H28P
  • C6H52PCH24PC6H52
  • C6H52PCH2CH2CH2CH2PC6H52
  • Catalysis and Inorganic Chemistry
  • Phosphine Ligands
  • Phosphorus Compounds
  • Polydentate Phosphine Ligands
  • Phosphines
  • Phosphine Ligands
  • Synthetic Organic Chemistry
  • Ligand
  • Achiral Phosphine
  • Aryl Phosphine
  • organophosphine ligand