5-Bromo-8-nitroisoquinoline

Uses

Product Name: 5-Bromo-8-nitroisoquinoline
CAS No.: 63927-23-1
Chemical Name: 5-Bromo-8-nitroisoquinoline
Synonyms: 5-BROMO-8-NITROISOQUINOLINE;5-BroMo-8-nitroisoquinolilne;Isoquinoline, 5-bromo-8-nitro-;5-Bromo-8-nitroisoquinoline >5-Bromo-8-nitroisoquinoline 90%;5-Bromo-8-nitroisoquinoline ISO 9001：2015 REACH
CBNumber: CB1779655
Molecular Formula: C9H5BrN2O2
Formula Weight: 253.05
MOL File: 63927-23-1.mol

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5-Bromo-8-nitroisoquinoline Property

Melting point:: 136-140 °C
Boiling point:: 386.9±27.0 °C(Predicted)
Density: 1.747±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 2?+-.0.36(Predicted)
color: Light yellow to Yellow to Orange
InChIKey: ULGOLOXWHJEZNZ-UHFFFAOYSA-N
CAS DataBase Reference: 63927-23-1(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-39-45
RIDADR: UN 2811
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 675148
Product name: 5-Bromo-8-nitroisoquinoline
Purity: 90%
Packaging: 1g
Price: $51.9
Updated: 2023/01/07

TCI Chemical

Product number: B4163
Product name: 5-Bromo-8-nitroisoquinoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $73
Updated: 2025/07/31

TRC

Product number: B686288
Product name: 5-Bromo-8-nitroisoquinoline
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B686288
Product name: 5-Bromo-8-nitroisoquinoline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42318
Product name: 5-Bromo-8-nitroisoquinoline
Packaging: 5G
Price: $40
Updated: 2021/12/16

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5-Bromo-8-nitroisoquinoline Chemical Properties,Usage,Production

Uses

5-Bromo-8-nitroisoquinoline is mainly used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the synthesis of drug molecules, pesticides, and dyes. In organic synthesis transformations, the bromine atom in 5-bromo-8-nitroisoquinoline can undergo debromination and hydrochemical oxidation under palladium and hydrogen conditions; in addition, the nitrogen atom on the isoquinoline ring can be oxidized to nitrogen oxides under the action of appropriate oxidizing agents.

Chemical Properties

It is light yellow solid powder under normal temperature and pressure, with certain alkalinity, can form salt with various acids.

Synthesis

34784-04-8

63927-23-1

Example 2: An aqueous solution of potassium nitrate (1.78 g, 8.56 mmol) was slowly added dropwise to a solution of 5-bromoisoquinoline dissolved in 12 mL of concentrated sulfuric acid. The reaction mixture was stirred at room temperature for 3 hours before it was poured into ice water and neutralized with concentrated ammonium hydroxide solution. The resulting yellow precipitate was extracted by ethyl acetate (3 x 10 mL) and the combined organic layers were washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-bromo-8-nitroisoquinoline in 96% yield using a hexane solution of 40% ethyl acetate as eluent.

References

[1] Patent: WO2004/76424, 2004, A1. Location in patent: Page 174-175
[2] Patent: EP698025, 1997, B1
[3] Patent: US5917053, 1999, A
[4] Patent: US5436250, 1995, A
[5] Patent: EP633262, 1995, A1

5-Bromo-8-nitroisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-8-nitroisoquinoline Suppliers

Americas 1 China 173 Europe 1 Germany 2 India 9 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 6 United States 33 Global 230

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View Lastest Price from 5-Bromo-8-nitroisoquinoline manufacturers

Career Henan Chemical Co

Product: 5-Bromo-8-nitroisoquinoline 63927-23-1
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

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63927-23-1

Halides

Heterocycles

Halogenated Heterocycles

Heterocyclic Building Blocks

Isoquinolines

IsoquinolinesBuilding Blocks