ChemicalBook > CAS DataBase List > Cyclopropylamine

Cyclopropylamine

Product Name
Cyclopropylamine
CAS No.
765-30-0
Chemical Name
Cyclopropylamine
Synonyms
Cyclopropanamine;AMINOCYCLOPROPANE;AURORA KA-2551;Cylopropylamine;Cydopropylamine;Cyloprolylamine;CYCLOPROPYLAMINE;Ring propylaMine;AKOS BBS-00003593;AMINOTRIMETHYLENE
CBNumber
CB1782699
Molecular Formula
C3H7N
Formula Weight
57.09
MOL File
765-30-0.mol
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Cyclopropylamine Property

Melting point:
-50 °C
Boiling point:
49-50 °C (lit.)
Density 
0.824 g/mL at 25 °C (lit.)
vapor pressure 
4.67 psi ( 20 °C)
refractive index 
n20/D 1.420(lit.)
Flash point:
−14 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
pka
pK1:9.10(+1) (25°C)
form 
Volatile Liquid
color 
Clear colorless
Specific Gravity
0.824
Water Solubility 
Miscible with water, ethanol,ether and chloroform.
Sensitive 
Lachrymatory
BRN 
741858
Stability:
Volatile
InChIKey
HTJDQJBWANPRPF-UHFFFAOYSA-N
LogP
0.070
CAS DataBase Reference
765-30-0(CAS DataBase Reference)
NIST Chemistry Reference
Cyclopropylamine(765-30-0)
EPA Substance Registry System
Cyclopropanamine (765-30-0)
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Safety

Hazard Codes 
F,C,Xi
Risk Statements 
11-22-34-36/37
Safety Statements 
16-26-36/37/39-45-33-7/9
RIDADR 
UN 2733 3/PG 2
WGK Germany 
2
RTECS 
GZ0685500
Autoignition Temperature
527 °F
Hazard Note 
Extremely Flammable/Harmful/Corrosive/Lachrymatory
TSCA 
T
HazardClass 
3
PackingGroup 
II
HS Code 
29213099
Toxicity
LD50 orally in Rabbit: 445 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18017
Product name
Cyclopropylamine
Purity
for synthesis
Packaging
10ml
Price
$38.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18017
Product name
Cyclopropylamine
Purity
for synthesis
Packaging
100mL
Price
$290
Updated
2024/03/01
Sigma-Aldrich
Product number
125504
Product name
Cyclopropylamine
Purity
98%
Packaging
10g
Price
$44.6
Updated
2024/03/01
Sigma-Aldrich
Product number
125504
Product name
Cyclopropylamine
Purity
98%
Packaging
25g
Price
$89.7
Updated
2024/03/01
TCI Chemical
Product number
C0981
Product name
Cyclopropylamine
Purity
>95.0%(GC)(T)
Packaging
5mL
Price
$20
Updated
2024/03/01
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Cyclopropylamine Chemical Properties,Usage,Production

Chemical Properties

Cyclopropylamine is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.

Uses

Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.

Definition

ChEBI: Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.

Application

Cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, and can be used in the synthesis of new antibacterial drugs ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, spafloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protection agents and herbicides, such as 2-chloro-4-6-cyclopropyl-s-triazine, cyprochlor, cyproterazine, cyprocyanine and other cyclopropanes class of pesticides.

Preparation

Cyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.

Biochem/physiol Actions

Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.

Purification Methods

It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]

Cyclopropylamine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate CHLORIC ACID Sodium hypochlorite 1,3-Propanediol Sodium Methoxide Gamma Butyrolactone

Preparation Products

1-CYCLOPROPYLPIPERAZINE 4-CHLORO-3-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE Ciprofloxacin hydrochloride Cyromazine 3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid ETHYL 3-(CYCLOPROPYLAMINO)ACRYLATE 1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE 2-N-Cyclopropylamino-4,6-DichloroTriazine 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid Enrofloxacin hydrochloride Ciprofloxacin Sparfloxacin 3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid
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Cyclopropylamine Suppliers

Americas 1 Austria 1 Belgium 4 Canada 2 China 375 Europe 4 France 4 Germany 10 India 73 Japan 6 Russia 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 19 United States 57 Global 561
Pure Chemistry Scientific Inc.
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View Lastest Price from Cyclopropylamine manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Cyclopropylamine 765-30-0
Price
US $10.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
10 ton
Release date
2024-08-23
Wuhan Xinhao Biotechnology Co., Ltd
Product
Cyclopropylamine 765-30-0
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2024-03-12
Changzhou Rokechem Technology Co., Ltd.
Product
Cyclopropylamine 765-30-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99%
Supply Ability
1-10000kgs
Release date
2023-09-11

765-30-0, CyclopropylamineRelated Search:

Tranylcypromine Isopropylamine Diisopropylamine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE TRANS-2-PHENYLCYCLOPROPYL ISOCYANATE D/L-AMPHETAMINE HYDROCHLORIDE Ciprofloxacin Rolicyprine Lorbamate Cyromazine CYCLOPROPYL ISOTHIOCYANATE 1-Aminocyclopropanecarboxylic acid 1-Aminocyclopropane-1-carboxylic acid hydrochloride Methyl 1-aminocyclopropanecarboxylate hydrochloride 1-(Cbz-amino)cyclopropanecarboxylic acid Tranylcypromine Hemisulfate tranylcypromine 1-BOC-3-AMINOPIPERIDINE

  • Cyclopropanamine
  • CYCLOPROPYLAMINE
  • AURORA KA-2551
  • AKOS BBS-00003593
  • AMINOCYCLOPROPANE
  • AMINOTRIMETHYLENE
  • Cyloprolylamine
  • Cyclopropyl amine(CPA)
  • Cydopropylamine
  • Cyclopropylamine,98%
  • Cylopropylamine
  • Cyclopropylamine 98%
  • CYCLOPROPYLAMINE W/O STABILIZING AGENT
  • CYCLOPROPYLAMINE W/STABILIZING AGENT
  • Cyclopropylamine ,99%
  • 1-Cyclopropanamine
  • Cyclopropylamine,Aminocyclopropane
  • CyclopropylaMine, 98% 25ML
  • CyclopropylaMine, 99% 10ML
  • CyclopropylaMine, 99% 50ML
  • CYCLOPROPYLAMINE FOR SYNTHESIS
  • CyclopropylaMine, 97+%
  • Ring propylaMine
  • Moxifloxacin Impurity 43
  • Cyclopropylamine &gt
  • 1-cyclopropyl-6,7-difluoro-8-methoxyquinolin-4(1H)-one
  • Cyclopropylamine (6CI, 7CI, 8CI)
  • Cyclopropylamine 98% For Synthesis
  • 765-30-0
  • 65-30-0
  • C3H7N
  • C3H5NH2
  • Simple 3-Membered Ring Compounds
  • Cyclopropanes
  • AMINE
  • Building Blocks
  • Amines
  • C2 to C6
  • Organic Building Blocks
  • Nitrogen Compounds
  • Pharmaceutical Intermediates
  • Cyclopropanes
  • Simple 3-Membered Ring Compounds