ChemicalBook > CAS DataBase List > 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate

9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate

Product Name
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
CAS No.
206184-49-8
Chemical Name
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
Synonyms
Tenofovir CRS;Tenofovir(H2O);Unii-99yxe507il;PMPA Monohydrate;Tenofovir (15 mg);Tenofovir (hydrate);R-PMPA of Tenofovir;Tenofovir (1643601);Tenofovir Monohydrate;Tenofovir hydrate (1:1)
CBNumber
CB1855342
Molecular Formula
C9H16N5O5P
Formula Weight
305.23
MOL File
206184-49-8.mol
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9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Property

Melting point:
270-274oC
storage temp. 
2-8°C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Safety

HS Code 
2933599550
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1592
Product name
Tenofovir
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1G
Price
$160
Updated
2022/05/15
Sigma-Aldrich
Product number
1643601
Product name
Tenofovir
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15MG
Price
$400
Updated
2022/05/15
TRC
Product number
T185533
Product name
TenofovirMonohydrate
Packaging
2.5g
Price
$145
Updated
2021/12/16
ChemScene
Product number
CS-1874
Product name
Tenofovir Hydrate
Purity
≥98.0%
Packaging
5mg
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
B1252
Product name
Tenofovir Hydrate
Packaging
50mg
Price
$221
Updated
2021/12/16
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9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Chemical Properties,Usage,Production

Chemical Properties

WHITE POWDER SOLID

Uses

Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug.

Uses

antineoplastic, thymidylate synthase inhibitor

Definition

ChEBI: A hydrate that is the monohydrate form of anhydrous tenovir.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tenofovir is a nucleotide analog reverse transcriptase inhibitor, and is widely used as an antiretroviral agent, for the treatment of HIV infection.

Biological Activity

tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].

References

[1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11.

9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Suppliers

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View Lastest Price from 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate manufacturers

Hangzhou ICH Biofarm Co., Ltd
Product
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate 206184-49-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
100kg
Release date
2023-07-12
Career Henan Chemical Co
Product
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate 206184-49-8
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-15

206184-49-8, 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrateRelated Search:

N-(n-Butyl)thiophosphoric triamide Hexamethylphosphoramide Glycine OLEYLOXYETHYL PHOSPHORYLCHOLINE Bucladesine MELIBIOSE Adenine Bensulfuron methyl Trimethyl phosphite Propyl gallate Thiophanate-methyl Kresoxim-methyl Methylparaben Choline glycerophosphate 6-Aminocaproic acid Propyl butyrate Dibutyryl adenosine cyclophosphate calcium Tenofovir disoproxil fumarate

  • 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
  • Unii-99yxe507il
  • Tenofovir Monohydrate
  • Tenofovir (15 mg)
  • Tenofovir (hydrate)
  • [[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid monohydrate
  • PMPA Monohydrate
  • (R)-(((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid hydrate
  • (r)-[[2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methyl]-phosphonic acid monohydrate
  • [(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methylphosphonic acid
  • (R)-9-(2-phosphonylmethoxy propyl)adenine(R-PMPA)
  • R-PMPA of Tenofovir
  • Tenofovir(H2O)
  • Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, hydrate (1:1)
  • 9-[(R)-2-(Phosphonomethoxy)propyl]adenine 1-hydrate
  • P-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid Hydrate
  • Tenofovir hydrate (GS 1278)
  • Tenofovir (1643601)
  • ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid hydrate
  • Tenofovir CRS
  • Tenofovir hydrate (1:1)
  • 9-[(R)-2-(Phosphonomethoxy)propyl] adenine monohydrate [PMPA]
  • 206184-49-8
  • C9H14N5O4PH2O
  • C9H16N5O5P
  • ALIMTA