Nigericin sodium salt

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Nigericin sodium salt

Product Name: Nigericin sodium salt
CAS No.: 28643-80-3
Chemical Name: Nigericin sodium salt
Synonyms: Nsc292567;Helexin C;Nigerian Sodium;Sodium Nigericin;Nigericin sodiuM sa;Nigericin sodium salt;Nigericin, monosodium salt;Nigericin, sodium salt(1:1);SODIUM NIGERICIN;NSC-292567;Nigericin sodium salt USP/EP/BP
CBNumber: CB1972391
Molecular Formula: C40H69NaO11
Formula Weight: 748.97
MOL File: 28643-80-3.mol

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Nigericin sodium salt Property

Melting point:: approximate 255℃
storage temp.: 2-8°C
solubility: Soluble in chloroform, methanol or ethanol
form: solution
color: White
Merck: 13,6569
BRN: 3892398
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey: MOYOTUKECQMGHE-NTQCAYBPSA-M
LogP: 4.817 (est)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-36/37/39-45
RIDADR: UN 3462 6.1/PG 3
WGK Germany: 3
RTECS: QT6840000
HazardClass: 6.1
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 481990
Product name: Nigericin sodium salt
Packaging: 5mg
Price: $80.7
Updated: 2023/01/07

Sigma-Aldrich

Product number: 481990
Product name: Nigericin sodium salt
Packaging: 10mg
Price: $129
Updated: 2022/05/15

Alfa Aesar

Product number: J61349
Product name: Nigericin sodium salt, 98+%
Packaging: 10mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 11437
Product name: Nigericin (sodium salt)
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 11437
Product name: Nigericin (sodium salt)
Purity: ≥98%
Packaging: 10mg
Price: $81
Updated: 2024/03/01

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Nigericin sodium salt Chemical Properties,Usage,Production

Description

Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin Na is K+> Rb+> Cs+>>Na+. Cell permeable.

Chemical Properties

NIGERICIN SODIUM SALT is white powder

Uses

Nigericin sodium is the atypical salt of nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.

Uses

Nigericin sodium is a salt of the atypical polyether antibiotic, nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.

Uses

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

General Description

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H⁺ (antiport). Transports monovalent cations across membranes with the following specificities: K⁺>Rb⁺>Cs⁺>>Na⁺. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.

Biochem/physiol Actions

Product does not compete with ATP.

storage

Store at -20°C

References

1) Akhmedov et al. (2010), Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells; FASEB J., 24 4613 2) Gong et al. (2010), Chemical probing reveals insights into the signaling mechanism of inflammasome activation; Cell Res., 20 1289

Nigericin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nigericin sodium salt manufacturers

Hebei Duling International Trade Co. LTD

Product: Nigericin sodium salt 28643-80-3
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2022-10-18

Hebei Mojin Biotechnology Co., Ltd

Product: Nigericin sodium salt 28643-80-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-31

Hebei Guanlang Biotechnology Co., Ltd.

Product: Nigericin sodium salt 28643-80-3
Price: US $1.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-06-15

28643-80-3, Nigericin sodium saltRelated Search:

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Nigericin sodium salt

Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464

Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A

Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate

Nigericin, monosodium salt

Nsc292567

Nigericin sodium salt,Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A

Nigericin sodiuM sa

Polyetherin A, AzaloMycin M, Helixin C, K 178, X 464, Pandavir

Nigericin Nigericin sodium salt

Helexin C

Nigericin, sodium salt(1:1)

Nigerian Sodium

Nigericin sodium salt, 98%, from Streptomyces hygroscopicus

(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyl- 2-tetrahydropyranyl]propanoic acid sodium salt

Nigericin, Sodium Salt, Streptomyces hygroscopicus - CAS 28643-80-3 - Calbiochem

Sodium Nigericin

SODIUM NIGERICIN;NSC-292567

Nigericin sodium salt USP/EP/BP

28643-80-3 C40H67O11Na Nigericin sodium salt

Sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2'R,3'S,5R,5'R)-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-3-methyltetrahydro-2H-pyran-2-yl)propanoate

28643-80-3

C40H67NaO11

C40H67O11Na

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