4,5-DICHLOROPYRIMIDINE
- Product Name
- 4,5-DICHLOROPYRIMIDINE
- CAS No.
- 6554-61-6
- Chemical Name
- 4,5-DICHLOROPYRIMIDINE
- Synonyms
- 4,5-DICHLOROPYRIMIDINE;PyriMidine,4,5-dichloro-;Pyrimidine, 4,5-dichloro- (7CI,8CI,9CI)
- CBNumber
- CB21010527
- Molecular Formula
- C4H2Cl2N2
- Formula Weight
- 148.98
- MOL File
- 6554-61-6.mol
4,5-DICHLOROPYRIMIDINE Property
- Boiling point:
- 82 °C(Press: 34 Torr)
- Density
- 1.493±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.41±0.16(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D438315
- Product name
- 4,5-Dichloropyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD12030
- Product name
- 4,5-Dichloropyrimidine
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD12030
- Product name
- 4,5-Dichloropyrimidine
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 072918
- Product name
- 4,5-Dichloropyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $444
- Updated
- 2021/12/16
- Product number
- NUC0001073
- Product name
- 4,5-DICHLOROPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $449
- Updated
- 2021/12/16
4,5-DICHLOROPYRIMIDINE Chemical Properties,Usage,Production
Synthesis
197228-37-8
6554-61-6
The general procedure for the synthesis of 4,5-dichloropyrimidine from the compound (CAS:197228-37-8) is as follows: 112.5 g (673.7 mmol) of 5-chloro-6-oxo-1,6-dihydropyrimidin-1-ium chloride was mixed with 1.6 mL of dimethylamine in 630 mL of phosphorochloride. The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, the excess phosphorus trichloride was removed by distillation under reduced pressure. After the reaction mixture was cooled, it was slowly poured into 1.5 L of ice water. The aqueous phase was extracted with 500 mL of dichloromethane, and the organic phases were combined and dried with anhydrous sodium sulfate. Finally, the organic phase was concentrated by decompression to give 72.3 g of 4,5-dichloropyrimidine in 66.3% yield.
References
[1] Patent: US2007/179295, 2007, A1
[2] Patent: US2007/275985, 2007, A1
[3] Patent: US2007/37828, 2007, A1
[4] Patent: WO2004/113342, 2004, A1. Location in patent: Page/Page column 49
[5] Patent: WO2005/851, 2005, A1. Location in patent: Page/Page column 59
4,5-DICHLOROPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4,5-DICHLOROPYRIMIDINE Suppliers
- Tel
- --
- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6581
- Advantage
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- Tel
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- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
View Lastest Price from 4,5-DICHLOROPYRIMIDINE manufacturers
- Product
- 4,5-Dichloropyrimidine 6554-61-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 4,5-DICHLOROPYRIMIDINE 6554-61-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-19