ZOTAROLIMUS
- Product Name
- ZOTAROLIMUS
- CAS No.
- 221877-54-9
- Chemical Name
- ZOTAROLIMUS
- Synonyms
- CS-1162;ABT 578;Resolute;A 179578;ZOTAROLIMUS;Unii-H4gxr80ize;ZotaroliMus API;Zotarolimus, >ZotaroliMus, >90%;ZotaroliMus(ABT-578)
- CBNumber
- CB21011766
- Molecular Formula
- C52H79N5O12
- Formula Weight
- 966.21
- MOL File
- 221877-54-9.mol
ZOTAROLIMUS Property
- Melting point:
- 100-105°C
- Boiling point:
- 1016.2±75.0 °C(Predicted)
- Density
- 1.25
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO, Methanol (Slightly)
- form
- Solid
- pka
- 10.40±0.70(Predicted)
- color
- White to Pale Yellow
Safety
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- 29246
- Product name
- Zotarolimus
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29246
- Product name
- Zotarolimus
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 29246
- Product name
- Zotarolimus
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29246
- Product name
- Zotarolimus
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- Z700800
- Product name
- Zotarolimus,>90%
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
ZOTAROLIMUS Chemical Properties,Usage,Production
Description
Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin . It binds to FKBP prolyl isomerase 1A (FKBP12; IC50 = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively). Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED50 = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 μg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis. Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.
Chemical Properties
Pale Yellow Solid
Uses
Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.
Uses
A tetrazole-containing Rapamycin analog as immunomodulator and useful in the treatment of restenosis and immune and autoimmune diseases.
Definition
ChEBI: Zotarolimus is a macrolide and a lactam.
ZOTAROLIMUS Preparation Products And Raw materials
Raw materials
Preparation Products
ZOTAROLIMUS Suppliers
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