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BAY 2666605

Product Name: BAY 2666605
CAS No.: 2275774-60-0
Chemical Name: BAY 2666605
Synonyms: BAY 266605;BAY 2666605;BAY 2666605 ，E1205;BAY 2666605, 10 mM in DMSO;(S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one;(S)-5-(4'-Fluoro-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one;2H-1,3,4-Oxadiazin-2-one, 5-[4'-fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-6-methyl-, (6S)-;anticancer effect,inhibit,BAY 2666605,orally active,PDE3A-SLFN12 Complex,Phosphodiesterase (PDE),BAY2666605,BAY-2666605,Inhibitor
CBNumber: CB210828953
Molecular Formula: C17H12F4N2O2
Formula Weight: 352.28
MOL File: 2275774-60-0.mol

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BAY 2666605 Property

Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 9.07±0.60(Predicted)
color: White to off-white
InChI: InChI=1S/C17H12F4N2O2/c1-9-15(22-23-16(24)25-9)11-4-7-13(14(8-11)17(19,20)21)10-2-5-12(18)6-3-10/h2-9H,1H3,(H,23,24)/t9-/m0/s1
InChIKey: JNTJTCXFIXNXDV-VIFPVBQESA-N
SMILES: O1[C@@H](C)C(C2=CC=C(C3=CC=C(F)C=C3)C(C(F)(F)F)=C2)=NNC1=O

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Hazard and Precautionary Statements (GHS)

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BAY 2666605 Chemical Properties,Usage,Production

Uses

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer.

in vitro

BAY 2666605 has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer.

in vivo

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer^[1].

IC 50

PDE3A: 87 nM (IC₅₀); PDE3B: 50 nM (IC₅₀)

BAY 2666605 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY 2666605 Suppliers

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BAY 2666605

anticancer effect,inhibit,BAY 2666605,orally active,PDE3A-SLFN12 Complex,Phosphodiesterase (PDE),BAY2666605,BAY-2666605,Inhibitor

2H-1,3,4-Oxadiazin-2-one, 5-[4'-fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-6-methyl-, (6S)-

BAY 266605

(S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one

BAY 2666605, 10 mM in DMSO

BAY 2666605 ，E1205

(S)-5-(4'-Fluoro-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one

2275774-60-0