MRS 2578
- Product Name
- MRS 2578
- CAS No.
- 711019-86-2
- Chemical Name
- MRS 2578
- Synonyms
- CS-1109;MRS 2578;MRS-2578; MRS2578;MRS 2578 USP/EP/BP;MRS 2578 >=95% (HPLC);MRS 2578;MRS-2578; MRS2578;MRS2578 P2Y6 antagonist MRS-2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA];1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
- CBNumber
- CB2112787
- Molecular Formula
- C20H20N6S4
- Formula Weight
- 472.67
- MOL File
- 711019-86-2.mol
MRS 2578 Property
- Melting point:
- 170 - 173°C
- Boiling point:
- 652.7±65.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- 2-8°C
- solubility
- DMSO: ~17 mg/mL
- form
- solid
- pka
- 11.80±0.70(Predicted)
- color
- white
- InChIKey
- QOHNRGHTJPFMSL-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-42
- Safety Statements
- 22-26-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M0319
- Product name
- MRS 2578
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- M0319
- Product name
- MRS 2578
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $572
- Updated
- 2024/03/01
- Product number
- 19704
- Product name
- MRS 2578
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 19704
- Product name
- MRS 2578
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 19704
- Product name
- MRS 2578
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $183
- Updated
- 2024/03/01
MRS 2578 Chemical Properties,Usage,Production
Description
MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6.
Uses
MRS 2578 has been used an antagonist of purinoceptor P2Y6:
- to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
- in P. aeruginosa infected mice to test its effect on the inflammatory responses
- to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes
Uses
MRS 2578 is a selective P2Y66?receptor antagonist.
Biological Activity
Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
Biochem/physiol Actions
MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.
storage
-20°C (desiccate)
References
[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770.
MRS 2578 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from MRS 2578 manufacturers
- Product
- MRS 2578 711019-86-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10