MRS 2578 Property

Melting point:

170 - 173°C

Boiling point:

652.7±65.0 °C(Predicted)

Density 

1.31

storage temp. 

2-8°C

solubility 

DMSO: ~17 mg/mL

form 

solid

pka

11.80±0.70(Predicted)

color 

white

InChIKey

QOHNRGHTJPFMSL-UHFFFAOYSA-N

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-42

Safety Statements 

22-26-36/37/39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

MRS 2578 Chemical Properties,Usage,Production

Description

MRS2578 is an antagonist of the purinergic P2Y₆ receptor (IC₅₀s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y₆.

Uses

MRS 2578 has been used an antagonist of purinoceptor P2Y6:

• to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
• in P. aeruginosa infected mice to test its effect on the inflammatory responses
• to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Uses

MRS 2578 is a selective P2Y66?receptor antagonist.

Biological Activity

Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

storage

-20°C (desiccate)

References

[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770.