MRS 2578

ChemicalBook > CAS DataBase List > MRS 2578

Product Name: MRS 2578
CAS No.: 711019-86-2
Chemical Name: MRS 2578
Synonyms: CS-1109;MRS 2578;MRS-2578; MRS2578;MRS 2578 USP/EP/BP;MRS 2578 >=95% (HPLC);MRS 2578;MRS-2578; MRS2578;MRS2578 P2Y6 antagonist MRS-2578;1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE;N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA];1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
CBNumber: CB2112787
Molecular Formula: C20H20N6S4
Formula Weight: 472.67
MOL File: 711019-86-2.mol

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MRS 2578 Property

Melting point:: 170 - 173°C
Boiling point:: 652.7±65.0 °C(Predicted)
Density: 1.31
storage temp.: 2-8°C
solubility: DMSO: ~17 mg/mL
form: solid
pka: 11.80±0.70(Predicted)
color: white
InChIKey: QOHNRGHTJPFMSL-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38-42
Safety Statements: 22-26-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M0319
Product name: MRS 2578
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: M0319
Product name: MRS 2578
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $572
Updated: 2024/03/01

Cayman Chemical

Product number: 19704
Product name: MRS 2578
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19704
Product name: MRS 2578
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 19704
Product name: MRS 2578
Purity: ≥98%
Packaging: 25mg
Price: $183
Updated: 2024/03/01

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MRS 2578 Chemical Properties,Usage,Production

Description

MRS2578 is an antagonist of the purinergic P2Y₆ receptor (IC₅₀s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y₆.

Uses

MRS 2578 has been used an antagonist of purinoceptor P2Y6:

to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
in P. aeruginosa infected mice to test its effect on the inflammatory responses
to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Uses

MRS 2578 is a selective P2Y66?receptor antagonist.

Biological Activity

Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

storage

-20°C (desiccate)

References

[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770.

MRS 2578 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from MRS 2578 manufacturers

Career Henan Chemical Co

Product: MRS 2578 711019-86-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

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N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA]

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MRS 2578;MRS-2578; MRS2578

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CS-1109

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MRS 2578 >=95% (HPLC)

MRS 2578 USP/EP/BP

1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)

MRS2578 P2Y6 antagonist MRS-2578

1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)

711019-86-2

C20H20N6S4

Inhibitors