4-Chloro-2-methoxyphenylboronic acid
- Product Name
- 4-Chloro-2-methoxyphenylboronic acid
- CAS No.
- 762287-57-0
- Chemical Name
- 4-Chloro-2-methoxyphenylboronic acid
- Synonyms
- 2-Borono-5-chloroanisole;4-Chloro-2-methoxyphenylboronic;oro-2-methoxybenzeneboronic acid;4-chloro-2-Methoxybenzaldehyde acid;4-Chloro-2-methoxybenzeneboronicaci;4-Chloro-2-methoxyphenylboronic aci;4-CHLORO-2-METHOXYPHENYLBORONIC ACID;2-Methoxy-4-chlorobenzeneboronic acid;4-CHLORO-2-METHOXYBENZENEBORONIC ACID;B-(4-Chloro-2-methoxyphenyl)boronic acid
- CBNumber
- CB2120832
- Molecular Formula
- C7H8BClO3
- Formula Weight
- 186.4
- MOL File
- 762287-57-0.mol
4-Chloro-2-methoxyphenylboronic acid Property
- Melting point:
- 128-134°C
- Boiling point:
- 345.4±52.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 8.42±0.58(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C7H8BClO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4,10-11H,1H3
- InChIKey
- NZRRMTBNTSBIFH-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(Cl)C=C1OC)(O)O
- CAS DataBase Reference
- 762287-57-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3248
- Product name
- 4-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $183
- Updated
- 2025/07/31
- Product number
- C3248
- Product name
- 4-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 200mg
- Price
- $60
- Updated
- 2025/07/31
- Product number
- C596833
- Product name
- 4-Chloro-2-methoxyphenylboronicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C2214
- Product name
- (4-Chloro-2-methoxyphenyl)boronicacid
- Purity
- 97%
- Packaging
- 25g
- Price
- $570
- Updated
- 2021/12/16
- Product number
- 126621
- Product name
- (4-Chloro-2-methoxyphenyl)boronicacid
- Purity
- >97%
- Packaging
- 25g
- Price
- $935
- Updated
- 2021/12/16
4-Chloro-2-methoxyphenylboronic acid Chemical Properties,Usage,Production
Uses
suzuki reaction
Synthesis
174913-09-8
121-43-7
762287-57-0
General procedure for the synthesis of 4-chloro-2-methoxyphenylboronic acid: preparation of intermediate I-1. 22.1 g (100 mmol) of 2-bromo-5-chloroanisole was dissolved in 500 mL of tetrahydrofuran (THF) and stirred for 10 min at -78 °C and protected by nitrogen (N2). Subsequently, 44 mL of a 2.5 M solution of n-butyllithium (n-BuLi) was slowly added through a dropping funnel and stirring was continued for 30 minutes. Next, 10.4 g (110 mmol) of trimethyl borate was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was warmed to room temperature and stirred for 3 hours. After completion of the reaction, the reaction was quenched with 300 mL of 1 M hydrochloric acid (HCl) and the organic layer was extracted three times with diethyl ether and washed with water. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography to afford 13.61 g of Intermediate I-1 (73 mmol, 73% yield). The resulting compound was characterized by mass spectrometry (MS/FAB): theoretical value of [M+H]+ (C7H8BClO3) 186.40, measured value 186.47.
References
[1] Organic Letters, 2016, vol. 18, # 15, p. 3630 - 3633
[2] Patent: US2016/190448, 2016, A1. Location in patent: Paragraph 0261; 0262; 0263
[3] Patent: US2016/190449, 2016, A1. Location in patent: Paragraph 0271; 0272
4-Chloro-2-methoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-2-methoxyphenylboronic acid manufacturers
- Product
- 4-Chloro-2-methoxyphenylboronic acid 762287-57-0
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 4-Chloro-2-methoxyphenylboronic acid 762287-57-0 762287-57-0
- Price
- US $66.00/KG
- Min. Order
- 1KG
- Purity
- 99.50% IN STOCK
- Supply Ability
- 20 MT per month
- Release date
- 2019-09-03
- Product
- 762287-57-0 4-Chloro-2-methoxybenzeneboronic acid 762287-57-0
- Price
- US $96.00/KG
- Min. Order
- 1KG
- Purity
- 99.50% IN STOCK
- Supply Ability
- 33 MT per month
- Release date
- 2019-09-03