ChemicalBook > CAS DataBase List > 5-Nitroisoquinoline

5-Nitroisoquinoline

Product Name: 5-Nitroisoquinoline
CAS No.: 607-32-9
Chemical Name: 5-Nitroisoquinoline
Synonyms: NSC 3017;5-NITROISOQUINOLINE;Isoquinoline,5-nitro-;5-Nitroisoquinoline 98%;5-Nitroisoquinoline?New;5-Nitroisoquinoline, 98+%;5-Nitroisoquinoline98%Or99%;5-Nitroisoquinoline, 98% 10GR;5-Nitroisoquinoline in isooctane;5-Nitroisoquinoline ISO 9001：2015 REACH
CBNumber: CB2121501
Molecular Formula: C9H6N2O2
Formula Weight: 174.16
MOL File: 607-32-9.mol

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5-Nitroisoquinoline Property

Melting point:: 106-109 °C (lit.)
Boiling point:: 305.12°C (rough estimate)
Density: 1.3146 (rough estimate)
refractive index: 1.5651 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 3.55±0.13(Predicted)
form: powder to crystal
color: Light yellow to Amber to Dark green
BRN: 134858
CAS DataBase Reference: 607-32-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-38-20/21/22-40
Safety Statements: 26-37/39-36/37/39-36-22
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 130222
Product name: 5-Nitroisoquinoline
Purity: 98%
Packaging: 5g
Price: $32.5
Updated: 2025/07/31

TCI Chemical

Product number: N0640
Product name: 5-Nitroisoquinoline
Packaging: 5g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: N0640
Product name: 5-Nitroisoquinoline
Packaging: 25g
Price: $194
Updated: 2025/07/31

TRC

Product number: N496390
Product name: 5-Nitroisoquinoline
Packaging: 25g
Price: $205
Updated: 2021/12/16

TRC

Product number: N496390
Product name: 5-Nitroisoquinoline
Packaging: 50g
Price: $330
Updated: 2021/12/16

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5-Nitroisoquinoline Chemical Properties,Usage,Production

Chemical Properties

light yellow crystal powder

Uses

5-Nitroisoquinoline (cas# 607-32-9) is a compound useful in organic synthesis.

Uses

5-Nitroisoquinoline was used to prepare a number of pyrroloisoquinolines.

General Description

5-Nitroisoquinoline reacted with vinylmagnesium bromide to form a number of pyrroloisoquinolines. 5-Nitroisoquinoline derivatives (potential antimalarial drugs) were evaluated for mutagenic (MUT) and chromosome-damaging (CHR) activities by the Salmonella test.

Synthesis

119-65-3

607-32-9

General procedure for the synthesis of 5-nitroisoquinoline from isoquinoline: 1. dissolve isoquinoline (3.0 g, 23.2 mmol) in 40 mL of concentrated sulfuric acid at -15 °C and slowly add solid potassium nitrate (2.8 g, 27.8 mmol) in four equal portions, each at 30 min intervals. 2. The reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. 3. The reaction mixture was poured into ice water (100 mL) and the pH was adjusted to 8-10 with ammonia. 4. The precipitated yellow solid was collected by filtration, washed with methyl tert-butyl ether (100 mL x 2) and dried to give 5-nitroisoquinoline (4.0 g, 100% yield). 5. 5-Nitroisoquinoline (2.5 g, 14.4 mmol) was dissolved in methanol (50 mL), 10% palladium/carbon catalyst (300 mg) was added, and stirred at room temperature for 3 hours under hydrogen atmosphere. 6. The reaction mixture was filtered and the filtrate was concentrated in vacuum to give 5-aminoisoquinoline (0.85 g, 41% yield) as a brown solid.

References

[1] Bioorganic Chemistry, 2019, vol. 82, p. 100 - 108
[2] Patent: WO2012/146724, 2012, A2. Location in patent: Page/Page column 49
[3] Patent: US2014/57942, 2014, A1. Location in patent: Paragraph 0337-0338
[4] Patent: WO2014/68035, 2014, A1. Location in patent: Page/Page column 35
[5] Journal of Organic Chemistry, 1986, vol. 51, # 11, p. 2011 - 2021

5-Nitroisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

Quinazoline

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5-Nitroisoquinoline Suppliers

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View Lastest Price from 5-Nitroisoquinoline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Nitroisoquinoline 607-32-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-04-07

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Nitroisoquinoline 607-32-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-25

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Nitroisoquinoline 607-32-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

607-32-9, 5-NitroisoquinolineRelated Search:

Isoquinoline 5-Nitroquinoline 3-Methylisoquinoline 4-Nitrobenzoic acid 1-METHYLISOQUINOLINE Nitrobenzene TRITON 4-Nitrophenol Nitromethane 8-BROMO-5-NITRO-ISOQUINOLINE 3-METHYL-5-NITROISOQUINOLINE 3-CHLORO-5-NITROISOQUINOLINE 7-(trifluoromethyl)-1,2,3,4-tetrahydro-5-nitroisoquinoline hydrochloride 5-BROMO-8-NITROISOQUINOLINE 4-NITROISOQUINOLINE 6-Methoxy-5-nitroisoquinoline 4-METHYL-5-NITROISOQUINOLINE METHYL 5-NITRO-3-ISOQUINOLINECARBOXYLATE

5-NITROISOQUINOLINE

Isoquinoline,5-nitro-

5-Nitroisoquinoline98%Or99%

5-Nitroisoquinoline, 98+%

5-Nitroisoquinoline, 98% 10GR

NSC 3017

5-Nitroisoquinoline 98%

5-Nitroisoquinoline ISO 9001：2015 REACH

5-Nitroisoquinoline?New

5-Nitroisoquinoline in isooctane

607-32-9

O2NC6H3C3H3N

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