5-Nitroisoquinoline
- Product Name
- 5-Nitroisoquinoline
- CAS No.
- 607-32-9
- Chemical Name
- 5-Nitroisoquinoline
- Synonyms
- NSC 3017;5-NITROISOQUINOLINE;Isoquinoline,5-nitro-;5-Nitroisoquinoline 98%;5-Nitroisoquinoline?New;5-Nitroisoquinoline, 98+%;5-Nitroisoquinoline98%Or99%;5-Nitroisoquinoline, 98% 10GR;5-Nitroisoquinoline in isooctane;5-Nitroisoquinoline ISO 9001：2015 REACH
- CBNumber
- CB2121501
- Molecular Formula
- C9H6N2O2
- Formula Weight
- 174.16
- MOL File
- 607-32-9.mol
5-Nitroisoquinoline Property
- Melting point:
- 106-109 °C (lit.)
- Boiling point:
- 305.12°C (rough estimate)
- Density
- 1.3146 (rough estimate)
- refractive index
- 1.5651 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.55±0.13(Predicted)
- form
- powder to crystal
- color
- Light yellow to Amber to Dark green
- BRN
- 134858
- CAS DataBase Reference
- 607-32-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-38-20/21/22-40
- Safety Statements
- 26-37/39-36/37/39-36-22
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 130222
- Product name
- 5-Nitroisoquinoline
- Purity
- 98%
- Packaging
- 5g
- Price
- $32.5
- Updated
- 2025/07/31
- Product number
- N0640
- Product name
- 5-Nitroisoquinoline
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- N0640
- Product name
- 5-Nitroisoquinoline
- Packaging
- 25g
- Price
- $194
- Updated
- 2025/07/31
- Product number
- N496390
- Product name
- 5-Nitroisoquinoline
- Packaging
- 25g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- N496390
- Product name
- 5-Nitroisoquinoline
- Packaging
- 50g
- Price
- $330
- Updated
- 2021/12/16
5-Nitroisoquinoline Chemical Properties,Usage,Production
Chemical Properties
light yellow crystal powder
Uses
5-Nitroisoquinoline (cas# 607-32-9) is a compound useful in organic synthesis.
Uses
5-Nitroisoquinoline was used to prepare a number of pyrroloisoquinolines.
General Description
5-Nitroisoquinoline reacted with vinylmagnesium bromide to form a number of pyrroloisoquinolines. 5-Nitroisoquinoline derivatives (potential antimalarial drugs) were evaluated for mutagenic (MUT) and chromosome-damaging (CHR) activities by the Salmonella test.
Synthesis
119-65-3
607-32-9
General procedure for the synthesis of 5-nitroisoquinoline from isoquinoline: 1. dissolve isoquinoline (3.0 g, 23.2 mmol) in 40 mL of concentrated sulfuric acid at -15 °C and slowly add solid potassium nitrate (2.8 g, 27.8 mmol) in four equal portions, each at 30 min intervals. 2. The reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. 3. The reaction mixture was poured into ice water (100 mL) and the pH was adjusted to 8-10 with ammonia. 4. The precipitated yellow solid was collected by filtration, washed with methyl tert-butyl ether (100 mL x 2) and dried to give 5-nitroisoquinoline (4.0 g, 100% yield). 5. 5-Nitroisoquinoline (2.5 g, 14.4 mmol) was dissolved in methanol (50 mL), 10% palladium/carbon catalyst (300 mg) was added, and stirred at room temperature for 3 hours under hydrogen atmosphere. 6. The reaction mixture was filtered and the filtrate was concentrated in vacuum to give 5-aminoisoquinoline (0.85 g, 41% yield) as a brown solid.
References
[1] Bioorganic Chemistry, 2019, vol. 82, p. 100 - 108
[2] Patent: WO2012/146724, 2012, A2. Location in patent: Page/Page column 49
[3] Patent: US2014/57942, 2014, A1. Location in patent: Paragraph 0337-0338
[4] Patent: WO2014/68035, 2014, A1. Location in patent: Page/Page column 35
[5] Journal of Organic Chemistry, 1986, vol. 51, # 11, p. 2011 - 2021
5-Nitroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Nitroisoquinoline manufacturers
- Product
- 5-Nitroisoquinoline 607-32-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-04-07
- Product
- 5-Nitroisoquinoline 607-32-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-25
- Product
- 5-Nitroisoquinoline 607-32-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12