morpholin-3-one

Product Name: morpholin-3-one
CAS No.: 109-11-5
Chemical Name: morpholin-3-one
Synonyms: 3-MORPHOLINONE;3-Oxomorpholine;in-3-on;3-morpholone;JACS-109-11-5;Morpholin-3-on;MORPHOLIN-3-ONE;morpholine-3-one;3-Ketomorpholine;3-Morpholinone>
CBNumber: CB2121662
Molecular Formula: C4H7NO2
Formula Weight: 101.1
MOL File: 109-11-5.mol

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morpholin-3-one Property

Melting point:: 103.0 to 107.0 °C
Boiling point:: 142°C/7mmHg(lit.)
Density: 1.122±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 14.37±0.20(Predicted)
color: White to Almost white
CAS DataBase Reference: 109-11-5(CAS DataBase Reference)
EPA Substance Registry System: 3-Morpholinone (109-11-5)

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Safety

Safety Statements: 24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2788
Product name: 3-Morpholinone
Purity: >98.0%(GC)
Packaging: 5g
Price: $56
Updated: 2024/03/01

TCI Chemical

Product number: M2788
Product name: 3-Morpholinone
Purity: >98.0%(GC)
Packaging: 25g
Price: $198
Updated: 2024/03/01

TRC

Product number: M723840
Product name: 3-Morpholinone
Packaging: 10g
Price: $75
Updated: 2021/12/16

TRC

Product number: M723840
Product name: 3-Morpholinone
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 074514
Product name: Morpholin-3-one
Purity: 95+%
Packaging: 25g
Price: $48
Updated: 2021/12/16

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morpholin-3-one Chemical Properties,Usage,Production

Description

3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.

Uses

3-Morpholinone is used as a reactant in the synthesis of 3-Morpholinone derivates. An example of this is 4-(4-Aminophenyl)-3-morpholinone, the key intermediate in the synthesis of Rivaroxaban (an anticoagulant).

References

He, Q., et al. "Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells." Bioorganic & Medicinal Chemistry 15.11(2007): 3889.
Murai, Hiromu, et al. "Morpholinone derivatives and method of use." US, US4237132. 1980.
Gonzalez-garcia, Maria Rosario, and Fernandez, Maria Carmen. "Morpholinyl derivatives useful as MOGAT-2 inhibitors." (2015).

morpholin-3-one Preparation Products And Raw materials

Raw materials

Sodium hydride Monoethanolamine Ethanol Toluene Methyl bromoacetate Ethyl acetate PETROLEUM ETHER

Preparation Products

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morpholin-3-one Suppliers

Americas 1 China 232 Europe 1 France 1 Germany 4 India 13 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 29 Global 291

CMS Chemicals Limited

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Apollo Scientific Ltd

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Melrob Ltd (part of Nordmann)

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Biosynth Carbosynth

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Manchester Organics

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Apollo Scientific Ltd.

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Carbosynth Limited

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ProdList: 6581
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View Lastest Price from morpholin-3-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: morpholin-3-one 109-11-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2021-12-13

Hebei Dangtong Import and export Co LTD

Product: morpholin-3-one 109-11-5
Price: US $40.00-36.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: 3-Morpholinone 109-11-5
Price: US $1.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-20

109-11-5, morpholin-3-oneRelated Search:

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Heterocycles series