5-BROMO-3-IODO-PYRIDIN-2-OL

Uses

Product Name: 5-BROMO-3-IODO-PYRIDIN-2-OL
CAS No.: 381233-75-6
Chemical Name: 5-BROMO-3-IODO-PYRIDIN-2-OL
Synonyms: 5-bromo-3-iodopyrazin-2-ol;5-Bromo-3-iodopyridine-2-ol;5-BroMo-3-iodopyridin-2(1H)-one;5-bromo-4-iodopyridin-2(1H)-one;5-BroMo-3-iodo-1H-pyridin-2-one;2-Hydroxy-3-iodo-5-bromopyridine;5-Bromo-2-hydroxy-3-iodopyridine;2(1H)-Pyridinone, 5-broMo-3-iodo-;5-Bromo-3-iodo-2-hydroxypyridine,97%;5-BroMo-3-iodo-2-hydroxypyridine, 97%
CBNumber: CB21229309
Molecular Formula: C5H3BrINO
Formula Weight: 299.89
MOL File: 381233-75-6.mol

More

Less

5-BROMO-3-IODO-PYRIDIN-2-OL Property

Melting point:: 226-227℃
Boiling point:: 307.9±42.0 °C(Predicted)
Density: 2.55±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.52±0.10(Predicted)
Appearance: Light yellow to yellow Solid
Sensitive: Light Sensitive
InChI: InChI=1S/C5H3BrINO/c6-3-1-4(7)5(9)8-2-3/h1-2H,(H,8,9)
InChIKey: WAUPPDAXWKLNNU-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)C=C1I
CAS DataBase Reference: 381233-75-6

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000304
Product name: 5-Bromo-3-iodo-pyridin-2-ol
Purity: Aldrich
Packaging: 1g
Price: $512
Updated: 2023/06/20

Matrix Scientific

Product number: 026130
Product name: 5-Bromo-3-iodo-pyridin-2-ol
Packaging: 25g
Price: $355
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139959
Product name: 5-Bromo-3-iodopyridin-2(1H)-one
Packaging: 10g
Price: $227.5
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-S-13
Product name: 5-Bromo-2-hydroxy-3-iodopyridine
Packaging: 25g
Price: $242
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139959
Product name: 5-Bromo-3-iodopyridin-2(1H)-one
Packaging: 25g
Price: $456
Updated: 2021/12/16

More

Less

5-BROMO-3-IODO-PYRIDIN-2-OL Chemical Properties,Usage,Production

Uses

5-BROMO-3-IODO-PYRIDIN-2-OL can be used as a pharmaceutical synthesis intermediate. It can be prepared by using 2-amino-5-bromopyridine as a reactant to prepare 2-amino-5-bromo-3-iodopyridine, followed by further diazotization; or it can be prepared by iodination using 5-bromo-2-hydroxypyridine as a reactant.

Synthesis

13466-38-1

381233-75-6

General procedure for the synthesis of 5-bromo-3-iodopyridin-2(1H)-one from 2-hydroxy-5-bromopyridine: 5-bromo-2-hydroxypyridine (2.5 g, 14.4 mmol), iodosuccinimide (4.7 g, 20.9 mmol), and acetonitrile (40 mL) were mixed, and the reaction was stirred for 20 min at 82 °C. After completion of the reaction, the mixture was cooled to room temperature and the solid was collected by filtration. The filter cake was recrystallized with ethyl acetate to afford the target product 5-bromo-2-hydroxy-3-iodopyridine (4.0 g) in 92.6% yield.

References

[1] Patent: CN108084186, 2018, A. Location in patent: Paragraph 0187-0188
[2] Synlett, 2003, # 11, p. 1678 - 1682
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1644 - 1668
[4] Patent: WO2015/132727, 2015, A1. Location in patent: Page/Page column 22; 28
[5] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71

5-BROMO-3-IODO-PYRIDIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-BROMO-3-IODO-PYRIDIN-2-OL Suppliers

China 95 Germany 1 India 7 United Kingdom 2 United States 9 Global 114

RR Scientific LLC

Tel: +86-13917743231
Email: sales@rrscientific.com
Country: United States
ProdList: 878
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

Adesis, Inc.

Tel: --
Fax: --
Email: info@adesisinc.com
Country: United States
ProdList: 512
Advantage: 64

More

Less

View Lastest Price from 5-BROMO-3-IODO-PYRIDIN-2-OL manufacturers

Career Henan Chemical Co

Product: 5-BROMO-3-IODO-PYRIDIN-2-OL 381233-75-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

381233-75-6, 5-BROMO-3-IODO-PYRIDIN-2-OLRelated Search:

5-BROMO-3-IODO-2-METHOXYPYRIDINE 5-BROMO-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-3-CHLORO-1H-INDAZOLE 5-Bromo-3-cyanoindole 5-BroMo-3,3-diMethylindoline 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene 1H-Indole, 5-broMo-3-iodo- Methyl-5-bromo-2 pyrimidine carboxylate 5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 2-Amino-3-Difluoromethoxy-5-Bromopyridine 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one 5-Bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine 3-Iodopyridine 3-Bromo-5-iodo-pyridine 5-BROMO-2-ETHOXY-3-IODO-PYRIDINE 5-BROMO-3-IODO-PYRIDIN-2-OL 5-BROMO-3-IODO-2-ISOPROPOXY-PYRIDINE

5-Bromo-2-hydroxy-3-iodopyridine

2(1H)-Pyridinone, 5-broMo-3-iodo-

5-BroMo-3-iodo-1H-pyridin-2-one

5-BroMo-3-iodo-2-hydroxypyridine, 97%

5‐bromo‐3‐iodo‐1,2‐dihydropyridin‐2‐one

5-bromo-2-hydroxy-3-iodopyridine, 5-bromo-3-iodopyridin-2-ol

5-BroMo-3-iodopyridin-2(1H)-one

5-Bromo-2-hydroxy-3-iodopyridine 95+%

5-bromo-4-iodopyridin-2(1H)-one

2-Hydroxy-3-iodo-5-bromopyridine

5-Bromo-3-iodo-2-hydroxypyridine,97%

5-bromo-3-iodopyrazin-2-ol

5-Bromo-3-iodopyridine-2-ol

5-Bromo-3-iodo-pyridin-2-ol

381233-75-6