Ethyl 1-aminocyclopropanecarboxylate hydrochloride

Product Name: Ethyl 1-aminocyclopropanecarboxylate hydrochloride
CAS No.: 42303-42-4
Chemical Name: Ethyl 1-aminocyclopropanecarboxylate hydrochloride
Synonyms: Ethyl 1-aminocyclopropane-1-carboxylate hydrochloride;H-ACPC-OET hydrochloride;ACPC-OEt HCl;ACPC-OMe HCl;H-AC3C-OET HCL;H-ACPC-OET HCL;H-CAIB-OET HCL;H-(1)NHCPROPN-OET HCL;H-AC3C-OEt Hydrochloride;H-ACPC-OET HCL USP/EP/BP
CBNumber: CB2125837
Molecular Formula: C6H12ClNO2
Formula Weight: 165.62
MOL File: 42303-42-4.mol

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Ethyl 1-aminocyclopropanecarboxylate hydrochloride Property

Melting point:: gt. 110.0 and le 118.0 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Water Solubility: Soluble in water
form: Crystalline Powder
color: White
CAS DataBase Reference: 42303-42-4

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36-38-36/37-24/25-22-7/9-36/37/39
WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000004
Product name: Ethyl 1-aminocyclopropanecarboxylate hydrochloride
Purity: Aldrich
Packaging: 1g
Price: $42.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 728934
Product name: Ethyl 1-aminocyclopropanecarboxylate hydrochloride
Purity: 97%
Packaging: 1g
Price: $60.01
Updated: 2025/07/31

TCI Chemical

Product number: E0937
Product name: Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: E0937
Product name: Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $113
Updated: 2025/07/31

TRC

Product number: E899835
Product name: Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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Ethyl 1-aminocyclopropanecarboxylate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

64-17-5

22059-21-8

42303-42-4

Thionyl chloride (150 mL, 2.056 mol) was slowly added to a suspension of 1-aminocyclopropanecarboxylic acid (100 g, 0.989 mol) in anhydrous ethanol (1 L) below 0 °C. The reaction mixture was stirred at 70 °C for 20 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: methanol, Rf = 0.4) to confirm that most of the raw materials had been consumed. Upon completion of the reaction, the solution was concentrated to give 210 g of crude product. The residue was dissolved in water and the pH was adjusted to 9-10 with potassium carbonate.Subsequently, the aqueous layer was extracted with dichloromethane (1L x 3). The organic layers were combined and concentrated to dryness. The residue was dissolved in ethyl acetate (300 mL) and a hydrochloride solution of ethyl hydrochloride (250 mL, 4 M) was slowly added at below -30°C. The mixture was stirred at 0 °C for 30 min, during which time a solid precipitated. Filtration under nitrogen protection gave ethyl 1-aminocyclopropane-1-carboxylate hydrochloride (132 g, 80.6% yield) as a white solid. The 1H-NMR data of the free amine were as follows (400 MHz, chloroform-d): δ[ppm] = 0.91-1.02 (m, 2H), 1.15-1.30 (m, 5H), 2.17 (s, 2H), 4.10 (d, 2H).

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 1840 - 1846
[2] Patent: WO2014/147021, 2014, A2. Location in patent: Page/Page column 129
[3] Patent: WO2015/140195, 2015, A1. Location in patent: Page/Page column 92; 93
[4] Patent: US2006/25589, 2006, A1. Location in patent: Page/Page column 9

Ethyl 1-aminocyclopropanecarboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 1-aminocyclopropanecarboxylate hydrochloride Suppliers

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View Lastest Price from Ethyl 1-aminocyclopropanecarboxylate hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Aminocyclopropane-1-carboxylic acid ethyl ester hydrochloride 42303-42-4
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: H-ACPC-OET HCL 42303-42-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

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