(2-Chloropyridin-3-yl)methanamine
- Product Name
- (2-Chloropyridin-3-yl)methanamine
- CAS No.
- 205744-14-5
- Chemical Name
- (2-Chloropyridin-3-yl)methanamine
- Synonyms
- RARECHEM AL BW 0316;2-chloro-3-PyridineMetha;3-AMINOMETHYL-2-CHLOROPYRIDINE;2-chloro-3-PyridineMethanaMine;(2-chloro-3-pyridyl)methylamine;(2-chloro-3-pyridyl)methanamine;3-Pyridinemethanamine, 2-chloro-;(2-Chloropyridin-3-yl)methanamine;(2-CHLORO-PYRIDIN-3-YL)-METHYLAMINE;3-Pyridinemethanamine,2-chloro-(9CI)
- CBNumber
- CB2129835
- Molecular Formula
- C6H7ClN2
- Formula Weight
- 142.59
- MOL File
- 205744-14-5.mol
(2-Chloropyridin-3-yl)methanamine Property
- Boiling point:
- 254.2±25.0 °C(Predicted)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 7.30±0.29(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C351045
- Product name
- (2-Chloropyridin-3-yl)methanamine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C351045
- Product name
- (2-Chloropyridin-3-yl)methanamine
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 3H30-5-48
- Product name
- (2-Chloropyridin-3-yl)methanamine
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Y8187
- Product name
- (2-Chloropyridin-3-yl)methanamine
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FC51809
- Product name
- (2-Chloropyridin-3-yl)methylamine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
(2-Chloropyridin-3-yl)methanamine Chemical Properties,Usage,Production
Synthesis
500732-62-7
205744-14-5
Triphenylphosphine (2.5 g, 9.5 mmol) was added to a solution of 3-azidomethyl-2-chloropyridine (1.4 g, 8.5 mmol) in anhydrous THF (30 mL) at 0 °C. The reaction mixture was slowly warmed to room temperature and stirred for 18 hours. Subsequently, NH4OH (3 mL) was added to the reaction mixture and stirring was continued for 3 hours. Next, the mixture was treated with 3M NaOH solution and stirred for 1 hour. The mixture was acidified to pH 2 by dropwise addition of 4 M HCl solution. after diluting the mixture with ether, the organic and aqueous layers were separated. The aqueous layer was extracted with ether and subsequently alkalized with 2M NaOH solution. The alkalized aqueous solution was extracted with CH2Cl2 (3×). The organic phases were combined, dried with MgSO4 and concentrated under reduced pressure to give a light yellow oily solid. The solid was diluted with ether and filtered. The filtrate was concentrated to give a light yellow oily substance. The crude product was purified by silica gel column chromatography using 20:1 CH2Cl2:MeOH as eluent to give 0.88 g (73% yield) of 3-aminomethyl-2-chloropyridine as a colorless oil.
References
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 4, p. 453 - 456
[2] Patent: US2006/25433, 2006, A1. Location in patent: Page/Page column 94
[3] Patent: US2005/10048, 2005, A1. Location in patent: Page/Page column 48
(2-Chloropyridin-3-yl)methanamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (2-Chloropyridin-3-yl)methanamine manufacturers
- Product
- (2-Chloropyridin-3-yl)methanamine 205744-14-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- (2-Chloropyridin-3-yl)methanamine 205744-14-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09