2-AMINO-4-CHLORO-5-NITROPYRIDINE

Product Name: 2-AMINO-4-CHLORO-5-NITROPYRIDINE
CAS No.: 24484-96-6
Chemical Name: 2-AMINO-4-CHLORO-5-NITROPYRIDINE
Synonyms: 2-AMino-4-chloro-5-nitrop...;4-Chloro-5-nitro-2-pyridinaMine;4-Chloro-5-nitropyridine-2-aMine;6-Amino-4-chloro-3-nitropyridine;2-Amino-5-nitro-4-chloropyridine;2-AMINO-4-CHLORO-5-NITROPYRIDINE;2-Pyridinamine, 4-chloro-5-nitro-;4-CHLORO-5-NITRO-PYRIDIN-2-YLAMINE;2-Amino-4-chloro-5-nitropyridine 96%;2-AMINO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber: CB2132006
Molecular Formula: C5H4ClN3O2
Formula Weight: 173.56
MOL File: 24484-96-6.mol

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2-AMINO-4-CHLORO-5-NITROPYRIDINE Property

Melting point:: 240-242°C
Boiling point:: 377℃
Density: 1.596
Flash point:: 182℃
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMF, DMSO, Hot Ethanol, Ethyl Acetate, Hot Methanol
form: Solid
pka: 1.77±0.24(Predicted)
color: Brown
CAS DataBase Reference: 24484-96-6

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: A1376-53
Product name: 2-Amino-4-chloro-5-nitropyridine
Packaging: 100mg
Price: $460
Updated: 2021/12/16

TRC

Product number: A603487
Product name: 2-Amino-4-chloro-5-nitropyridine
Packaging: 1g
Price: $1200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011047
Product name: 2-AMINO-4-CHLORO-5-NITROPYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $1963.5
Updated: 2021/12/16

Matrix Scientific

Product number: 101936
Product name: 4-Chloro-5-nitropyridin-2-amine
Purity: 95%
Packaging: 5g
Price: $699
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17567
Product name: 2-Amino-4-chloro-5-nitropyridine
Packaging: 5G
Price: $432
Updated: 2021/12/16

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2-AMINO-4-CHLORO-5-NITROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Synthesis

19798-80-2

6980-08-1

24484-96-6

Example 13 (a) Procedure for the synthesis of 4-chloro-3-nitropyridin-2-amine (Aust. J. Chem. 1982,35,2025.): 4-chloro-2-aminopyridine (10 g, 77.5 mmol) was dissolved in concentrated sulfuric acid (100 mL) and cooled to about -8°C using a salt-ice bath. Fuming nitric acid was added slowly with stirring, keeping the reaction temperature below 0°C. After addition, the reaction mixture was stirred at room temperature for 20 minutes, followed by careful pouring onto ice. A 32% ammonium hydroxide solution was slowly added while the temperature was controlled with an ice bath below 25 °C until the solution pH reached 3. The solid product was collected by filtration, washed with water and recrystallized from a 1:1 aqueous solution. The resulting solid was added to ice-cold concentrated sulfuric acid (200 mL) in batches, controlling the rate of addition to maintain the temperature below 4 °C. After addition, the reaction mixture was allowed to come to room temperature. After 2.5 hours of reaction, two regional isomers (1:1 ratio), 3-nitro and 5-nitro compounds, were detected by LCMS. The reaction mixture was poured into ice and alkalized with 32% ammonium hydroxide solution. It was filtered and washed with water to obtain a mixture of the two regional isomers. The mixture was dissolved in ethyl acetate and heptane was added to precipitate the unwanted regional isomer. The isomer is removed by filtration and the ethyl acetate is evaporated to give the target product and 15-20% of the impure isomer. In addition, the two isomers could be separated by rapid chromatography on silica gel (Combiflash system) and an appropriate ethyl acetate/heptane gradient. The final product was obtained as 5 g in 37% yield. m/z 172 (M-1) by MS (ESI), 174. 2.2 min RT (LCMS, 254 nm).

References

[1] Tetrahedron Letters, 2012, vol. 53, # 42, p. 5597 - 5601
[2] Patent: WO2007/40438, 2007, A2. Location in patent: Page/Page column 59
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734,14
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734
[5] Patent: WO2013/190320, 2013, A1. Location in patent: Paragraph 00117; 00118

2-AMINO-4-CHLORO-5-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4-CHLORO-5-NITROPYRIDINE Suppliers

Canada 1 China 124 Germany 2 India 17 Sweden 1 United Kingdom 2 United States 15 Global 162

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

Tel: --
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Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

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View Lastest Price from 2-AMINO-4-CHLORO-5-NITROPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 2-AMINO-4-CHLORO-5-NITROPYRIDINE 24484-96-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 2-AMINO-4-CHLORO-5-NITROPYRIDINE 24484-96-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-20

24484-96-6, 2-AMINO-4-CHLORO-5-NITROPYRIDINERelated Search:

2,5-Dichloro-4-iodopyridine 2-AMINO-6-CHLORO-3-NITROPYRIDINE,2-Amino-6-chloro-3-nitropyridine 98%,6-Amino-2-chloro-5-nitropyridine 2-AMINO-5-CHLORO-3-NITROPYRIDINE,2-AMINO-5-CHLORO-3-NITROPYRIDINE 98+% GC,2-AMINO-5-CHLORO-3-NITROPYRIDINE, 98+% 4-AMINO-2-CHLORO-3-NITROPYRIDINE 2-AMINO-5-CHLORO-3-NITROPYRIDINE 3-Amino-2-chloro-4-nitropyridine 2-AMINO-4-CHLORO-3-NITROPYRIDINE 2-AMINO-3-CHLORO-5-NITROPYRIDINE, 95+%,2-AMINO-3-CHLORO-5-NITROPYRIDINE 2-Amino-5-Chloro-3-NitroPyridine5409392 2-Methylamino-3-nitro-6-chloropyridine 6-Amino-2-chloro-3-nitropyridine 4-Chloro-3-nitropyridine 3-Amino-4-chloropyridine 2-AMINO-4-CHLORO-5-NITROPYRIDINE

4-CHLORO-5-NITRO-PYRIDIN-2-YLAMINE

2-AMINO-4-CHLORO-5-NITROPYRIDINE

2-Pyridinamine, 4-chloro-5-nitro-

2-Amino-4-chloro-5-nitropyridine 96%

6-Amino-4-chloro-3-nitropyridine

4-Chloro-5-nitropyridine-2-aMine

4-Chloro-5-nitro-2-pyridinaMine

2-AMino-4-chloro-5-nitrop...

2-AMINO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH

2-Amino-5-nitro-4-chloropyridine

24484-96-6

24484-94-6

Amines

Aromatics

Heterocycles

Miscellaneous Reagents

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides

Pyridines

Amino-pyridine series

API intermediates