2-Methylamino-3-nitro-6-chloropyridine

Product Name: 2-Methylamino-3-nitro-6-chloropyridine
CAS No.: 33742-70-0
Chemical Name: 2-Methylamino-3-nitro-6-chloropyridine
Synonyms: 2-METHYLAMINO-3-NITRO-6-CHLORO;2-Chloro-5-nitro-6-methylaminopyridine;2-Methylamino-3-nitro-6-chloropyridine;6-Chloro-N-methyl-3-nitro-2-pyridinamine;2-Chloro-6-(methylamino)-5-nitropyridine;6-Chloro-2-(methylamino)-3-nitropyridine;6-Chloro-2-(N-methylamino)-3-nitropyridine;2-PYRIDINAMINE, 6-CHLORO-N-METHYL-3-NITRO-;Pyridine, 6-chloro-2-(methylamino)-3-nitro-;(6-Chloro-3-nitro-pyridin-2-yl)-Methyl-aMine
CBNumber: CB8421232
Molecular Formula: C6H6ClN3O2
Formula Weight: 187.58
MOL File: 33742-70-0.mol

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2-Methylamino-3-nitro-6-chloropyridine Property

Melting point:: 114 °C
Boiling point:: 330 °C
Density: 1.489
Flash point:: 153 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: -0.67±0.10(Predicted)
Appearance: White to yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C349770
Product name: 6-Chloro-2-(N-methylamino)-3-nitropyridine
Packaging: 500mg
Price: $165
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H55-5-42
Product name: 2-Chloro-5-nitro-6-methylaminopyridine
Purity: 95.0%
Packaging: 1g
Price: $122
Updated: 2021/12/16

Matrix Scientific

Product number: 126420
Product name: 6-Chloro-N-methyl-3-nitropyridin-2-amine
Purity: >95%
Packaging: 1g
Price: $432
Updated: 2021/12/16

AK Scientific

Product number: V1853
Product name: 2-Methylamino-3-nitro-6-chloropyridine
Packaging: 10g
Price: $532
Updated: 2021/12/16

Matrix Scientific

Product number: 126420
Product name: 6-Chloro-N-methyl-3-nitropyridin-2-amine
Purity: >95%
Packaging: 5g
Price: $1350
Updated: 2021/12/16

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2-Methylamino-3-nitro-6-chloropyridine Chemical Properties,Usage,Production

Synthesis

16013-85-7

74-89-5

33742-70-0

General procedure for the synthesis of 2-methylamino-3-nitro-6-chloropyridine (9) from 2,6-dichloro-3-nitropyridine (8) (2.0 g, 10.4 mmol) and monomethylamine: 2,6-dichloro-3-nitropyridine (8) and sodium carbonate (2.75 g, 25.9 mmol) were suspended in ethanol (100 mL). Subsequently, methylamine solution (7.8 mL, 15.6 mmol, 2M) was added to the suspension and the resulting mixture was stirred and reacted for 3 hours at room temperature. Upon completion of the reaction, the yellow reaction solution was concentrated under reduced pressure and the residue was dissolved in ethyl acetate and washed sequentially with sodium bicarbonate solution and saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting yellow solid was purified by recrystallization from ethanol to afford the target product 6-chloro-N-methyl-3-nitropyridin-2-amine (9) as a yellow solid (1.6 g, 82% yield). Mass spectrum (MS) m/z (M+H): calculated value=187.6; measured value=187.1. 1H NMR (400MHz, DMSO-d6): δ3.00 (3H, d, J=5.1Hz), 6.77 (1H, d, J=8.1Hz), 8.42 (1H, d, J=8.1Hz), 8.72 (1H, m).

References

[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3052 - 3066
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 4, p. 1260 - 1264
[3] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 312 - 317
[4] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 1013; 1014
[5] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 209

2-Methylamino-3-nitro-6-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methylamino-3-nitro-6-chloropyridine Suppliers

China 67 Germany 1 India 2 Ukraine 1 United Kingdom 1 United States 15 Global 87

Pure Chemistry Scientific Inc.

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Shanghai potentpharm CO.,Ltd

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9ding chemical ( Shanghai) Limited

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Shanghai Worldyang Chemical Co.,Ltd.

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Tianjin Anhao Biological Technology Co., Ltd.

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Shanghai HuanChuan Industry Co.,Ltd.

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View Lastest Price from 2-Methylamino-3-nitro-6-chloropyridine manufacturers

Dideu Industries Group Limited

Product: 2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 2-Methylamino-3-nitro-6-chloropyridine 33742-70-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kgs
Release date: 2020-01-08

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33742-70-0

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