Propitocaine hydrochloride

Product Name: Propitocaine hydrochloride
CAS No.: 1786-81-8
Chemical Name: Propitocaine hydrochloride
Synonyms: xylonest;Prilocaine HC;PRILOCAINE HCL;Citanest Plain;Prilocaine HCI;Ropitocaine Hcl;Propitocaine HCL;l-67hydrochloride;prilocainechloride;citanesthydrochloride
CBNumber: CB2139212
Molecular Formula: C13H21ClN2O
Formula Weight: 256.77
MOL File: 1786-81-8.mol

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Propitocaine hydrochloride Property

Melting point:: 168-170°C
storage temp.: 2-8°C
solubility: Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone
form: solid
color: White to Off-White
Merck: 14,7743
InChI: InChI=1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
InChIKey: BJPJNTKRKALCPP-UHFFFAOYSA-N
SMILES: C1(=CC=CC=C1C)NC(=O)C(C)NCCC.Cl
CAS DataBase Reference: 1786-81-8(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: UG5775000
HS Code: 29242990
Toxicity: man,LDLo,parenteral,12343ug/kg/1H (12.343mg/kg),BLOOD: HEMORRHAGE,Journal of Analytical Toxicology. Vol. 10, Pg. 75, 1986.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3106
Product name: Prilocaine Hydrochloride
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $182
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP497
Product name: Prilocaine hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $257
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1561008
Product name: Prilocaine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: P3347
Product name: Prilocaine hydrochloride
Purity: meets USP testing specifications
Packaging: 1g
Price: $99
Updated: 2022/05/15

Sigma-Aldrich

Product number: BP497
Product name: Prilocaine hydrochloride
Purity: British Pharmacopoeia (BP) Reference Standard
Price: $220
Updated: 2021/12/16

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Propitocaine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

antibacterial

Uses

Propitocaine hydrochloride is a local anesthetic of the amino amide type,it is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.

Uses

Anesthetic (local).

Definition

ChEBI: The monohydrochloride salt of prilocaine.

brand name

Citanest (AstraZeneca).

Biological Functions

Prilocaine hydrochloride (Citanest) is an amide anesthetic whose onset of action is slightly longer than that of lidocaine; its duration of action is comparable. Prilocaine is 40% less toxic acutely than lidocaine, making it especially suitable for regional anesthetic techniques. It is metabolized by the liver to orthotoluidine, which when it accumulates, can cause conversion of hemoglobin (HB⁺⁺⁺ to methemoglobin (HB⁺⁺⁺. Oxygen transport is impaired in the presence of methemoglobinemia. Treatment involves the use of reducing agents, such as methylene blue, given intravenously, to reconvert methemoglobin to hemoglobin.

Contact allergens

Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA? cream.

Side effects

Common adverse reactions include bradycardia, hypotension, urticaria, edema, anaphylactoid reactions, lightheadedness, nervousness, euphoria, confusion, dizziness, drowsiness, tinnitus. The safety and effectiveness of prilocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies.

Propitocaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Propitocaine hydrochloride Suppliers

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View Lastest Price from Propitocaine hydrochloride manufacturers

Hebei Miaoyin Technology Co.,Ltd

Product: Prilocaine hydrochloride 1786-81-8
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000
Release date: 2023-04-06

Jinan Million Pharmaceutical Co., Ltd

Product: Propitocaine hydrochloride 1786-81-8
Price: US $2.00/kg
Min. Order: 0.10000000kg
Purity: 99%
Supply Ability: 200KG
Release date: 2024-07-23

Wuhan Biocar Pharmacy CO.,Ltd.

Product: Prilocaine HCl 1786-81-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 800kg
Release date: 2025-02-24

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1786-81-8

C13H20N2OHCl