ChemicalBook > CAS DataBase List > 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

Product Name
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
CAS No.
72537-17-8
Chemical Name
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
Synonyms
2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-;3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%;TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
CBNumber
CB2145237
Molecular Formula
C6H2ClF4N
Formula Weight
199.53
MOL File
72537-17-8.mol
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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Property

Melting point:
16-20 °C (lit.)
Boiling point:
50-55 °C/11 mmHg (lit.)
Density 
1.524 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.433(lit.)
Flash point:
125 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Liquid
color 
Colorless
InChI
InChI=1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
InChIKey
GDSROTVTTLUHCO-UHFFFAOYSA-N
SMILES
C1(F)=NC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference
72537-17-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
10-36/37/38
Safety Statements 
26-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
3.2
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
393576
Product name
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity
98%
Packaging
5g
Price
$105
Updated
2023/01/07
TCI Chemical
Product number
C2671
Product name
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$55
Updated
2025/07/31
TRC
Product number
C367783
Product name
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
018282
Product name
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity
97%
Packaging
25g
Price
$62
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-7-08
Product name
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity
97%
Packaging
5G
Price
$65
Updated
2021/12/16
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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

General Description

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.

Synthesis

69045-84-7

72537-17-8

The general procedure for the synthesis of 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: Example 3b. Equipment: 250 mL four-necked round-bottomed flask equipped with a thermometer, mechanical stirrer, dropping funnel and inert gas inlet. Operating steps: 1. 25 mL of DMSO was added to a 250 mL four-necked round-bottomed flask, and the solvent was evaporated from a suspension of 150 mL of DMSO, 2.5 g of potassium carbonate (17.9 mmol), and 25.0 g of cesium fluoride (162.9 mmol) at 120 °C and 25-30 mbar pressure. 2. 25.0 g of 2,3-dichloro-5-trifluoromethylpyridine (112.3 mmol) was added to the reaction mixture and the reaction was stirred at 120 °C for 4 hours. 3. After completion of the reaction, the suspension was filtered and the product 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine was distilled directly from the distillate at 95 to 115 °C and 40-60 mbar pressure to obtain the product in quantitative yield. PRODUCT ANALYSIS: GC analysis showed a product purity of 96.9 area percent.

References

[1] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 9-10
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6
[3] Patent: CN107286087, 2017, A. Location in patent: Paragraph 0032; 0033
[4] Patent: CN106905231, 2017, A. Location in patent: Paragraph 0077; 0078; 0079; 0080; 0081; 0082; 0083-0085
[5] Patent: EP1199305, 2002, A1. Location in patent: Page 6

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Suppliers

Americas 1 China 154 Europe 1 Germany 7 India 2 Japan 1 Switzerland 3 United Kingdom 14 United States 28 Global 211
Ark Pharm, Inc.
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View Lastest Price from 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Shandong Jihui Chemical Co., Ltd.
Product
2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine 72537-17-8
Price
US $0.00-0.00/KG
Min. Order
250KG
Purity
Purity: 99%
Supply Ability
1000tons
Release date
2025-07-20
Dideu Industries Group Limited
Product
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27
Career Henan Chemical Co
Product
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

72537-17-8, 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINERelated Search:

Picoxystrobin 2-Cyano-3,5-difluoropyridine 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 3-Chloro-2-fluorobenzotrifluoride 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine 2,3-DIFLUOROBENZOTRIFLUORIDE 3-Chloro-5-(trifluoromethyl)pyridine 2-Chloro-3-fluoro-6-(trifluoromethyl)pyridine 2-CHLORO-3-FLUORO-4-(TRIFLUOROMETHYL)PYRIDINE 2-Chloro-5-fluoro-3-(trifluoromethyl)pyridine 5-Chloro-2-fluoro-3-(trifluoromethyl)pyridine 3-Chloro-2-fluoro-pyridine 3-Chloro-2-fluoro-5-methylpyridine 2-Fluoro-5-methylpyridine 2-Fluoro-5-trifluoromethylpyridine 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

  • 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
  • 2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE
  • CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
  • 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%
  • 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine &gt
  • Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-
  • 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
  • TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
  • 72537-17-8
  • 71537-17-8
  • C6H2ClF4N
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Pyridines
  • C6Heterocyclic Building Blocks