Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate

Product Name: Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate
CAS No.: 179688-27-8
Chemical Name: Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate
Synonyms: Erlotinibint-E1;Erlotinib Imp.42;Erlotinib Impurity 89;Erlotinib interMidiate IV;Ethyl 2-amino-4,5-bis(2-methoxyethoxy);4,5-bis(2-methoxyethoxy)-2-aminobenzoate;Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate;Ethyl 2-aMino-4,5-bis(2-Methoxyethoxy)benzoate;Methyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate;ethyl 2-aMino-4,5-bis(2-Methoxyethoxy)benzoate HCL
CBNumber: CB21458213
Molecular Formula: C15H23NO6
Formula Weight: 313.35
MOL File: 179688-27-8.mol

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Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate Property

Boiling point:: 456.4±45.0 °C(Predicted)
Density: 1.148
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 2.52±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A602006
Product name: 2-Amino-4,5-bis(2-methoxyethoxy)benzoicAcidEthylEster
Packaging: 1g
Price: $195
Updated: 2021/12/16

TRC

Product number: A602006
Product name: 2-Amino-4,5-bis(2-methoxyethoxy)benzoicAcidEthylEster
Packaging: 500mg
Price: $120
Updated: 2021/12/16

TRC

Product number: A602006
Product name: 2-Amino-4,5-bis(2-methoxyethoxy)benzoicAcidEthylEster
Packaging: 5g
Price: $525
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0078004
Product name: ETHYL 4,5-BIS(2-METHOXYETHOXY)-2-AMINOBENZOATE
Purity: 95.00%
Packaging: 1KG
Price: $8899.16
Updated: 2021/12/16

AK Scientific

Product number: B655
Product name: Ethyl4,5-bis(2-methoxyethoxy)-2-aminobenzoate
Packaging: 1g
Price: $136
Updated: 2021/12/16

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Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate Chemical Properties,Usage,Production

Uses

2-Amino-4,5-bis(2-methoxyethoxy)benzoic Acid Ethyl Ester is an intermediate in the synthesis of Erlotinib (E625000, HCl); a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and antineoplastic agent.

Synthesis

179688-26-7

179688-27-8

GENERAL METHOD: A mixture of ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate (1.0 mmol), hydrazine hydrate (NH2NH2-H2O, 2.5 eq.), and H2O2-treated activated charcoal powder (AC, 50 wt%) in N,N-dimethylformamide (DMF, 1.5 mL) was placed under vigorous magnetic stirring at 100 °C. . The reaction process was monitored by liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS). Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst. The combined organic phases were dried with anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by distillation under reduced pressure to afford the target product ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate. All the compounds were confirmed by 1H nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis and validated by comparison with data reported in the literature.

References

[1] Journal of Chemical Research, 2017, vol. 41, # 9, p. 509 - 512
[2] Patent: CN107382880, 2017, A. Location in patent: Paragraph 0028
[3] Research on Chemical Intermediates, 2013, vol. 39, # 6, p. 2303 - 2309
[4] Patent: CN103709110, 2016, B. Location in patent: Paragraph 0065; 0066
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2005, vol. 48, # 11, p. 829 - 843

Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate Suppliers

China 127 India 6 United States 5 Global 138

Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

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View Lastest Price from Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate manufacturers

Shandong Xuhuang New material CoLTD

Product: Ethyl4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-8
Price: US $35.00/KG
Min. Order: 1KG
Purity: 99.99%
Supply Ability: 200
Release date: 2025-02-21

Hebei Runbin Biotechnology Co. LTD

Product: Erlotinib Intermediate 179688-27-8
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500 Ton/Tons per Month
Release date: 2020-09-25

Career Henan Chemical Co

Product: Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-8
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2018-07-27

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Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate

2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ester

2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester

4,5-Bis(2-methoxyethoxy)anthranilic acid ethyl ester

Methyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate

Ethyl 2-aMino-4,5-bis(2-Methoxyethoxy)benzoate

Erlotinib interMidiate IV

ethyl 2-aMino-4,5-bis(2-Methoxyethoxy)benzoate HCL

Benzoic acid,2-aMino-4,5-bis(2-Methoxyethoxy)-, ethyl ester

Erlotinib Impurity 89

Ethyl 4,5-bis(2-methoxyethoxy)-2-aminobenzoate 2-Amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester

Ethyl 2-amino-4,5-bis(2-methoxyethoxy)

4,5-bis(2-methoxyethoxy)-2-aminobenzoate

Erlotinib Imp.42

2-amino-4.5 - bis -(methoxy ethoxy) ethyl benzoate

Erlotinibint-E1

179688-27-8

C15H23NO6

Erlotinib INTERMEDIATES

intermidiate of Erlotinib hydrochloride