ChemicalBook > CAS DataBase List > 2,4-Dichloro-3-iodopyridine

2,4-Dichloro-3-iodopyridine

Uses

Product Name: 2,4-Dichloro-3-iodopyridine
CAS No.: 343781-36-2
Chemical Name: 2,4-Dichloro-3-iodopyridine
Synonyms: Pyridine, 2,4-dichloro-3-iodo-
CBNumber: CB21471058
Molecular Formula: C5H2Cl2IN
Formula Weight: 273.89
MOL File: 343781-36-2.mol

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2,4-Dichloro-3-iodopyridine Property

Melting point:: 90-94 °C
Boiling point:: 290.3±35.0 °C(Predicted)
Density: 2.129±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: -1.17±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
RIDADR: UN 2811
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 721069
Product name: 2,4-Dichloro-3-iodopyridine
Purity: 97%
Packaging: 1g
Price: $52
Updated: 2023/01/07

TRC

Product number: D435258
Product name: 2,4-Dichloro-3-iodopyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: D435258
Product name: 2,4-Dichloro-3-iodopyridine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W5591
Product name: 2,4-Dichloro-3-iodopyridine
Packaging: 5g
Price: $131
Updated: 2021/12/16

Matrix Scientific

Product number: 057338
Product name: 2,4-Dichloro-3-iodopyridine
Purity: 98%
Packaging: 5g
Price: $84
Updated: 2021/12/16

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2,4-Dichloro-3-iodopyridine Chemical Properties,Usage,Production

Uses

2,4-Dichloro-3-iodopyridine can be used as a pharmaceutical synthesis intermediate. It is prepared by reacting 2,4-dichloropyridine with n-butyllithium and iodine, and can be used to prepare another intermediate, 2,4-dichloro-3-trifluoromethylpyridine. It can also be obtained by iodination of 2,4-dichloropyridine or by chlorination of 2,4-dihydroxy-3-iodopyridine with phosphorus oxychloride.

Synthesis

26452-80-2

343781-36-2

General procedure for the synthesis of 2,4-dichloro-3-iodopyridine from 2,4-dichloropyridine: To a solution of anhydrous tetrahydrofuran (THF, 40 mL) of 2,4-dichloropyridine (5.2 g, 35.137 mmol) and N,N-diisopropylethylamine (DIPEA, 3.911 g, 38.651 mmol), the solution was cooled to -50 °C under nitrogen protection. At -78 °C, n-butyllithium (n-BuLi, 24.157 mL, 38.651 mmol, 1.6 M in hexane solution) was added dropwise. The reaction mixture was stirred at -78 °C for 45 min. Subsequently, a solution of iodine (9.81 g, 38.651 mmol) in anhydrous THF (20 mL) was added dropwise. The mixture was continued to be stirred at -78 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature, diluted with ethyl acetate (EtOAc) and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) and saturated aqueous sodium thiosulfate (Na2S2O3). The organic layer was separated, the organic extracts were combined, washed with saturated aqueous sodium bicarbonate (NaHCO3), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel as stationary phase, heptane/dichloromethane gradient elution, dichloromethane up to 20%). The fraction containing the target product was collected and concentrated under reduced pressure to afford the intermediate compound 2,4-dichloro-3-iodopyridine (D5, 7.8 g, 81% yield).

References

[1] European Journal of Organic Chemistry, 2001, # 7, p. 1371 - 1376
[2] Patent: WO2010/130422, 2010, A1. Location in patent: Page/Page column 53
[3] Patent: WO2010/130423, 2010, A1. Location in patent: Page/Page column 53
[4] Patent: WO2010/130424, 2010, A1. Location in patent: Page/Page column 104-105
[5] Patent: WO2012/62752, 2012, A1. Location in patent: Page/Page column 26

2,4-Dichloro-3-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-3-iodopyridine manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: 2,4-Dichloro-3-iodopyridine 343781-36-2
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-09-25

PNP Biotech Co. Ltd

Product: 2,4-Dichloro-3-iodopyridine 343781-36-2
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-17

Career Henan Chemical Co

Product: 2,4-Dichloro-3-iodopyridine 343781-36-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-19

343781-36-2, 2,4-Dichloro-3-iodopyridineRelated Search:

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Pyridine, 2,4-dichloro-3-iodo-

343781-36-2

Heterocycle-Pyridine series