ChemicalBook > CAS DataBase List > H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2

H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2

Product Name
H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
CAS No.
83930-34-1
Chemical Name
H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
Synonyms
CRF OVINE;TYR-CRF (OVINE);[TYR0]-CRF OVINE;TYR-CORTICOTROPIN RELEASING FACTOR OVINE;[TYR0]-CORTICOTROPIN RELEASING FACTOR, OVINE;YSQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH2;TYROSINE-CORTICOTROPIN RELEASING FACTOR BOVINE);Corticotropin-releasing factor(sheep),N-L-tyrosyl-;H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-TH;TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
CBNumber
CB2161583
Molecular Formula
C214H348N60O65S
Formula Weight
4833.48092
MOL File
83930-34-1.mol
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H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 Property

storage temp. 
−20°C
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 Chemical Properties,Usage,Production

Uses

[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2].

in vivo

[Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys[1].

Animal Model:Young adult male cynomolgus monkeys (4.0-6.9 kg)[1]
Dosage:10 mL/h for 198 pg/min or 225 pg/min
Administration:Continuous infusions intravenous; collected every 60 min during 5-7 hr
Result:Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).

References

[1] Schulte HM, et al. Metabolic clearance rate and plasma half-life of radioiodinated corticotropin releasing factor in a primate. J Clin Endocrinol Metab. 1982 Nov;55(5):1023-5. DOI:10.1210/jcem-55-5-1023
[2] Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7. DOI:10.1016/s0006-8993(01)03160-2

H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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83930-34-1, H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2Related Search:

TYR-CORTICOTROPIN RELEASING FACTOR HUMAN, RAT TYR-AMYLOID P COMPONENT (27-38) AMIDE TYR-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG Tyr-α-CGRP (human) TYR-LEPTIN (26-39) (HUMAN) TYR-ACTH (4-10) N-TRICOSANOYLTRYPTAMINE H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2 TYR-MET-GLU-HIS-PHE-ARG-TRP TYR-CORTICOTROPIN RELEASING FACTOR HUMAN, RAT Tosylmethyl isocyanide SALCOMINE Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) METHYL ISOCYANOACETATE Cupric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)

  • CRF OVINE
  • H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
  • YSQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH2
  • TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2 OVINE
  • [TYR0]-CORTICOTROPIN RELEASING FACTOR, OVINE
  • [TYR0]-CRF OVINE
  • TYR-CORTICOTROPIN RELEASING FACTOR OVINE
  • TYR-CRF (OVINE)
  • TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2: YSQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH2
  • TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-THR-LYS-ALA-ASP-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-LEU-ASP-ILE-ALA-NH2
  • TYROSINE-CORTICOTROPIN RELEASING FACTOR BOVINE)
  • H-TYR-SER-GLN-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-TH
  • Corticotropin-releasing factor(sheep),N-L-tyrosyl-
  • 83930-34-1
  • C214H348N60O65S
  • CRF
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • Peptides
  • Releasing Factors
  • CRF
  • Peptides for Cell Biology
  • Releasing Factors