Physical Form
ChemicalBook > CAS DataBase List > 6-Iodo-1H-indazole

6-Iodo-1H-indazole

Physical Form
Product Name
6-Iodo-1H-indazole
CAS No.
261953-36-0
Chemical Name
6-Iodo-1H-indazole
Synonyms
6-IODOINDAZOLE;6-IodoindazoL;6-iodo-1h1indazole;6-IODO (1H)INDAZOLE;1H-Indazole, 6-iodo-;Axitinib Intermediate 3;6-IODO (1H)INDAZOLE ISO 9001:2015 REACH
CBNumber
CB2178484
Molecular Formula
C7H5IN2
Formula Weight
244.03
MOL File
261953-36-0.mol
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6-Iodo-1H-indazole Property

Melting point:
207.0 to 211.0 °C
Boiling point:
358.2±15.0 °C(Predicted)
Density 
2.082±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
12.96±0.40(Predicted)
form 
Liquid
color 
Clear colorless to light yellow
InChI
InChI=1S/C7H5IN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)
InChIKey
RSGAXJZKQDNFEP-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC(I)=C2)C=N1
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Safety

HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
I0933
Product name
6-Iodoindazole
Purity
>98.0%(GC)
Packaging
1g
Price
$168
Updated
2024/03/01
TCI Chemical
Product number
I0933
Product name
6-Iodoindazole
Purity
>98.0%(GC)
Packaging
5g
Price
$584
Updated
2024/03/01
TRC
Product number
I707370
Product name
6-Iodo-1H-indazole
Packaging
250mg
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
068734
Product name
6-Iodoindazole
Purity
95+%
Packaging
1g
Price
$98
Updated
2021/12/16
Matrix Scientific
Product number
068734
Product name
6-Iodoindazole
Purity
95+%
Packaging
5g
Price
$337
Updated
2021/12/16
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6-Iodo-1H-indazole Chemical Properties,Usage,Production

Physical Form

Light yellow to Brown powder to crystal

Uses

6-Iodo-1H-indazole is an intermediate used to synthesize inhibitors of Chk1.

Synthesis Reference(s)

[1] NOOLVI M N, PATEL H M. Small Molecule Tyrosine Kinase Inhibitors: The New Dawn for Cancer Therapy[J]. Letters in Drug Design & Discovery, 1900, 9(1): 84-125. DOI:10.2174/157018012798192892.

Synthesis

Revill P. and co-worker synthesized Axitinib by iodination of 6-iodo-1H-indazole (100) to give 3,6-di iodo- 1H-indazole (101) ,which on further reaction with 2- mercapto-N-methylbenzenesulfinamide gives 2-(3-iodo-1Hindazol-6-ylthio)-N-methylbenzamide (101), the same can be obtained via 2-(1H-indazol-6-ylthion)-N-methylbenzamide (102) starting from 6-iodo-1H-indazole (100) through alternative route. N-protection of 2-(3-iodo-1H-indazol-6- ylthio)-N-methylbenzamide (101) by Boc2, DMAP or DHP, TsOH gives respective N-protected intermediates 103, 104. Further treatment of 103, 104 with 2-vinyl pyridine give rise to N-protected-2-(1-methyl-3-(2-(pyridine-2-yl) vinyl)-1Hindazole-6-ylthio) benzothioamide 105 and 106. Deprotection of 105 and 106 gives destination compound axitinib (107), the same can be obtained without protection from 2-(3-iodo-1H-indazol-6-ylthio)-N-methylbenzamide (101) by simple reaction with 2-vinyl pyridine[1].

6-Iodo-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Iodo-1H-indazole Suppliers

JW & Y Pharmlab Co., Ltd.
Tel
021-64340559 13651849907;
Fax
021- 64345308
Email
xinyu_shi@jwypharmlab.com.cn
Country
China
ProdList
12036
Advantage
58
Jinan XinKe Pharmaceutical Technology Co., Ltd.
Tel
0531-88259693 17854196142
Fax
0531-88259693
Email
2820602043@qq.com
Country
China
ProdList
83
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
259
Advantage
61
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Yangzhou Siyu Chemical Co.,Ltd.
Tel
0514-87325867
Fax
0086-514-87325867
Email
sales@siyuchem.com
Country
China
ProdList
370
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
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View Lastest Price from 6-Iodo-1H-indazole manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
6-Iodo-1H-indazole 261953-36-0
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200
Release date
2023-12-11
Hebei Weibang Biotechnology Co., Ltd
Product
6-IODO (1H)INDAZOLE 261953-36-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
6-Iodo-1H-indazole 261953-36-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% by HPLC
Supply Ability
100kg/month
Release date
2023-01-05