6-Iodo-1H-indazole

ChemicalBook > CAS DataBase List > 6-Iodo-1H-indazole

Physical Form

Product Name: 6-Iodo-1H-indazole
CAS No.: 261953-36-0
Chemical Name: 6-Iodo-1H-indazole
Synonyms: 6-IODOINDAZOLE;6-IodoindazoL;6-iodo-1h1indazole;6-IODO (1H)INDAZOLE;1H-Indazole, 6-iodo-;Axitinib Intermediate 3;6-IODO (1H)INDAZOLE ISO 9001：2015 REACH
CBNumber: CB2178484
Molecular Formula: C7H5IN2
Formula Weight: 244.03
MOL File: 261953-36-0.mol

Less

6-Iodo-1H-indazole Property

Melting point:: 207.0 to 211.0 °C
Boiling point:: 358.2±15.0 °C(Predicted)
Density: 2.082±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.96±0.40(Predicted)
form: Liquid
color: Clear colorless to light yellow
InChI: InChI=1S/C7H5IN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)
InChIKey: RSGAXJZKQDNFEP-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(I)=C2)C=N1

Less

Safety

HS Code: 29339980

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: I0933
Product name: 6-Iodoindazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $168
Updated: 2024/03/01

TCI Chemical

Product number: I0933
Product name: 6-Iodoindazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $584
Updated: 2024/03/01

TRC

Product number: I707370
Product name: 6-Iodo-1H-indazole
Packaging: 250mg
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 068734
Product name: 6-Iodoindazole
Purity: 95+%
Packaging: 1g
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 068734
Product name: 6-Iodoindazole
Purity: 95+%
Packaging: 5g
Price: $337
Updated: 2021/12/16

Less

6-Iodo-1H-indazole Chemical Properties,Usage,Production

Physical Form

Light yellow to Brown powder to crystal

Uses

6-Iodo-1H-indazole is an intermediate used to synthesize inhibitors of Chk1.

Synthesis Reference(s)

[1] NOOLVI M N, PATEL H M. Small Molecule Tyrosine Kinase Inhibitors: The New Dawn for Cancer Therapy[J]. Letters in Drug Design & Discovery, 1900, 9(1): 84-125. DOI:10.2174/157018012798192892.

Synthesis

Revill P. and co-worker synthesized Axitinib by iodination of 6-iodo-1H-indazole (100) to give 3,6-di iodo- 1H-indazole (101) ,which on further reaction with 2- mercapto-N-methylbenzenesulfinamide gives 2-(3-iodo-1Hindazol-6-ylthio)-N-methylbenzamide (101), the same can be obtained via 2-(1H-indazol-6-ylthion)-N-methylbenzamide (102) starting from 6-iodo-1H-indazole (100) through alternative route. N-protection of 2-(3-iodo-1H-indazol-6- ylthio)-N-methylbenzamide (101) by Boc2, DMAP or DHP, TsOH gives respective N-protected intermediates 103, 104. Further treatment of 103, 104 with 2-vinyl pyridine give rise to N-protected-2-(1-methyl-3-(2-(pyridine-2-yl) vinyl)-1Hindazole-6-ylthio) benzothioamide 105 and 106. Deprotection of 105 and 106 gives destination compound axitinib (107), the same can be obtained without protection from 2-(3-iodo-1H-indazol-6-ylthio)-N-methylbenzamide (101) by simple reaction with 2-vinyl pyridine^[1].

6-Iodo-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

Less

6-Iodo-1H-indazole Suppliers

Americas 1 China 236 Europe 1 France 1 Germany 2 India 13 Japan 1 United Kingdom 4 United States 19 Global 278

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12036
Advantage: 58

Jinan XinKe Pharmaceutical Technology Co., Ltd.

Tel: 0531-88259693 17854196142
Fax: 0531-88259693
Email: 2820602043@qq.com
Country: China
ProdList: 100
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 264
Advantage: 61

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Yangzhou Siyu Chemical Co.,Ltd.

Tel: 0514-87325867
Fax: 0086-514-87325867
Email: sales@siyuchem.com
Country: China
ProdList: 370
Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9371
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Shanghai Scientia Pharmaceutical Technology Co., Ltd.

Tel: 21-21-54301573 13917723525
Fax: (86)21-51861981
Email: sales@scientiapharm.com
Country: China
ProdList: 263
Advantage: 62

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9510
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

SpringPharma Tech Co.,Ltd

Tel: +86-25-68710855, +86-25-68710897
Fax: 025-68710856
Email: sales@springpharma.net
Country: China
ProdList: 1261
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4001
Advantage: 55

Shanghai Shenyue Chemical Co., Ltd.

Tel: 021-021-52212593 18049974220
Fax: +86 (21) 51062076
Email: 3060526242@qq.com
Country: China
ProdList: 984
Advantage: 60

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 3890
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9478
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 18927339850
Fax: 0752-5319394
Email: xiaodong.shi@rafflespt.com
Country: China
ProdList: 238
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 18017383231 18017383231
Fax: qq：2817624287
Email: lyh_antaeus@163.com
Country: China
ProdList: 9347
Advantage: 55

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 021-34666753 13311639313
Fax: +86-21-34979012
Email: info@shyrchem.com
Country: China
ProdList: 571
Advantage: 55

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Sheepchem Co., Ltd.

Tel: +86 (21) 6715-7650
Fax: +86 (21) 6715-7651
Email: sheepchem@163.com
Country: China
ProdList: 994
Advantage: 60

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Devinchem Ltd

Tel: 027-65318838 13646286950
Email: sales@devinchem.com
Country: China
ProdList: 2997
Advantage: 58

Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.

Tel: 0515-89701588 13770166955
Fax: 0515-87400189
Email: orgunion@orgunion.com
Country: China
ProdList: 620
Advantage: 55

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1913
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Jiaxing Novartis Chemical Co., Ltd.

Tel: 18957373295
Fax: -
Country: China
ProdList: 1580
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10274
Advantage: 55

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Nova(Shanghai) Pharmaceutical Co.,Ltd

Tel: 21-58226973 18917146209
Fax: +86-21-51685790
Email: Joseph@novapharmas.com
Country: China
ProdList: 495
Advantage: 55

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 3967
Advantage: 60

Haiyan Difu Chemical Co., Ltd.

Tel: 0573-86186729 15957397789
Fax: 0573-86722262
Country: China
ProdList: 71
Advantage: 60

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 492
Advantage: 65

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: sales@kahn-pharm.com
Country: China
ProdList: 1782
Advantage: 55

Less

View Lastest Price from 6-Iodo-1H-indazole manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 6-Iodo-1H-indazole 261953-36-0
Price: US $1.00-0.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200
Release date: 2023-12-11

Hebei Mujin Biotechnology Co.,Ltd

Product: 6-IODO (1H)INDAZOLE 261953-36-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

Hebei Mojin Biotechnology Co.,Ltd

Product: 6-IODO (1H)INDAZOLE 261953-36-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-08-14

261953-36-0, 6-Iodo-1H-indazoleRelated Search:

6-Iodo-1H-indazole 4-IODO (1H)INDAZOLE 3-Iodo-6-nitroindazole 4-Fluoro-3-iodo-1H-indazole 5-BROMO-3-IODO (1H)INDAZOLE 1H-INDAZOLE, 3-BROMO-7-IODO- 5-Fluoro-3-iodo-1H-indazole 5-CHLORO-3-IODO-1H-INDAZOLE 5-Iodo-1H-indazole 3-Amino-4-iodo-1H-indazole 3-BROMO-6-IODO (1H)INDAZOLE 3-HYDROXY-6-IODO (1H)INDAZOLE 3,6-DIIODO-4-METHYL (1H)INDAZOLE 4,6-DIIODO-1H-INDAZOLE 6-IODO-3-(1H)INDAZOLE CARBOXYLIC ACID 6-IODO-3-(1H)INDAZOLE CARBOXALDEHYDE 4-AMINO-3-HYDROXY-6-IODO-1H-INDAZOLE 6-IODO-4-METHYL (1H)INDAZOLE

6-IODO (1H)INDAZOLE

6-IODOINDAZOLE

6-iodo-1h1indazole

1H-Indazole, 6-iodo-

6-IodoindazoL

6-IODO (1H)INDAZOLE ISO 9001：2015 REACH

Axitinib Intermediate 3

261953-36-0

pharmacetical

Intermediate