Brand Name(s) in US
ChemicalBook > CAS DataBase List > Cefotaxime sodium

Cefotaxime sodium

Brand Name(s) in US
Product Name
Cefotaxime sodium
CAS No.
64485-93-4
Chemical Name
Cefotaxime sodium
Synonyms
CEFOTAXIME SODIUM STERILE;ctx;CEFOTAXIME SODIUM SALT;CLAFORAN;Sodium cefotaxime;CEFOTAXIME NA-SALT;CEFOTAXIM SODIUM SALT;Cefotaxime Sodium (350 mg);Cefotaxime for peak identification;Cefotaxime, Sodium Salt, High Purity, Cell Culture-Tested
CBNumber
CB2197478
Molecular Formula
C16H18N5NaO7S2
Formula Weight
479.46
MOL File
64485-93-4.mol
More
Less

Cefotaxime sodium Property

Melting point:
162-163 C
alpha 
D20 +55±2° (c = 0.8 in water)
refractive index 
61 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
form 
powder
color 
white to yellow
PH
pH(100g/l, 25℃) : 4.5～6.5
optical activity
[α]/D +58 to +64°, c =1 in H2O
Water Solubility 
Soluble in water.
Merck 
14,1933
BRN 
5711411
Stability:
Stable. Incompatible with strong oxidizing agents.
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
42/43
Safety Statements 
22-36/37-60-45-37-24
WGK Germany 
2
RTECS 
XI0250000
HS Code 
29419000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2099
Product name
Cefotaxime Sodium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$160
Updated
2024/03/01
Sigma-Aldrich
Product number
C7039
Product name
Cefotaxime sodium salt
Purity
plant cell culture tested, BioReagent, powder
Packaging
1g
Price
$291
Updated
2024/03/01
Sigma-Aldrich
Product number
1097909
Product name
Cefotaxime sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
J62690
Product name
Cefotaxime sodium salt
Packaging
1g
Price
$108
Updated
2024/03/01
Alfa Aesar
Product number
J62690
Product name
Cefotaxime sodium salt
Packaging
5g
Price
$220
Updated
2024/03/01
More
Less

Cefotaxime sodium Chemical Properties,Usage,Production

Brand Name(s) in US

Claforan

Description

Cefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.

Chemical Properties

White to pale yellow crystalline powder

Originator

Claforan,Hoechst-Roussel,W. Germany,1980

Uses

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group

Uses

Cephalosporin antibacterial

Uses

Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

Definition

ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.

Manufacturing Process

A solution of 8 g of sodium bicarbonate in about 20 ml of ethanol was progressively added to 45.55 g of pure 3-acetoxymethyl-7-[2-(2-amino-4- thiazolyl)-2-methoxyiminoacetamido]-ceph-3-eme-4-carboxylic acid in 100 ml of distilled water and another 80 ml of ethanol and 4.5 g of activated carbon were added thereto. The mixture was stirred for 5 minutes and was filtered. The filter was rinsed with ethanol and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in 100 ml of ethanol and evaporated to dryness again. The residue was dissolved in 100 ml of methanol and the solution was poured into 2 l of acetone. The mixture was vigorously stirred and was vacuum filtered. The recovered product was rinsed with acetone and then ether and dried under reduced pressure to obtain 43.7 g of a white product which rehydrated in air to obtain a final weight of 45.2 g of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2- methoxyiminoacetamido]-ceph-3-eme-4-carboxylate.

brand name

Claforan (Sanofi Aventis).

Therapeutic Function

Antibiotic

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biological Activity

mic: <0.1 μg/ml for s. pneumoniaecefotaxime is a cephalosporin antibiotic.the cephalosporins, a class of β-lactam antibiotics originally derived from the fungus acremonium, are indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Clinical Use

Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.
The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.

Veterinary Drugs and Treatments

In the United States, there are no cefotaxime products approved for veterinary species but it has been used clinically in several species when an injectable 3rd generation cephalosporin may be indicated.

in vitro

previous studies found that the in-vitro activity of cefotaxime against staphylococcus au reus has ranged from 0.8 g to 8 μg/ml with 50% of isolates inhibited by 2 μg/ml and 90% by 4 μg/ml. moreover, it was found that methicillin resistant s. aureus were resistant to cefotaxime with mic values above 64 μg/ml. the cefotaxime mics against s. pneumoniae were found to be below 0.1 μg/ml, with 90% inhibited by 0.04 μg/ml. cefotaxime has also been shown to have excellent activity against haemophilus injluenzae, such as β-lactamase-containing strains [1].

in vivo

an in-vivo study with the mouse model of vibrio vulnificus infection was conducted to evaluate the efficacies of therapy with minocycline or cefotaxime alone and in combination. results indicated that combination therapy with cefotaxime and minocycline was distinctly more advantageous than therapy with the single antibiotic regimen for the treatment of severe vibrio vulnificus infections [2].

References

[1] neu hc. the in vitro activity, human pharmacology, and clinical effectiveness of new beta-lactam antibiotics. annu rev pharmacol toxicol. 1982;22:599-642.
[2] chuang yc, ko wc, wang st, liu jw, kuo cf, wu jj, huang ky. minocycline and cefotaxime in the treatment of experimental murine vibrio vulnificus infection. antimicrob agents chemother. 1998 jun;42(6):1319-22.
[3] schleupner cj, engle jc. clinical evaluation of cefotaxime for therapy of lower respiratory tract infections. antimicrob agents chemother. 1982 feb;21(2):327-33.

Cefotaxime sodium Preparation Products And Raw materials

Raw materials

Lithium tert-butoxide Triethylamine hydrochloride Sodium acetate Hexane Ethanol N,N-Dimethylformamide Acetone 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Phosphorus pentachloride Ethyl acetate Dichloromethane Thiazole Methanol Glycinamide N,N-Dimethylacetamide 1-Butanol

Preparation Products

Cefmenoxime
More
Less

Cefotaxime sodium Suppliers

Americas 1 Argentina 1 Austria 2 Bangladesh 1 Belgium 2 Brazil 1 Canada 1 China 480 Czech Republic 1 Europe 4 France 3 Germany 12 India 65 Italy 5 Japan 3 Nigeria 1 Philippines 1 Poland 2 Singapore 1 Slovenia 1 South Korea 5 Spain 3 Switzerland 4 The Netherlands 3 United Kingdom 20 United States 49 Global 672
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Triveni chemicals
Tel
--
Fax
--
Email
sales@trivenichemical.com
Country
India
ProdList
6088
Advantage
58
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
marketing@srlchem.com
Country
India
ProdList
4315
Advantage
58
Shagun Pharmaceuticals
Tel
--
Fax
--
Email
info@shagunpharma.com
Country
India
ProdList
193
Advantage
58
Aruvi Labs
Tel
--
Fax
--
Email
info@aruvilabs.com
Country
India
ProdList
68
Advantage
58
Athos Chemicals
Tel
--
Fax
--
Email
export@athoschemicals.com
Country
India
ProdList
315
Advantage
58
Unitrade Agencies
Tel
--
Fax
--
Country
India
ProdList
197
Advantage
58
Vipul Drugs Pvt., Ltd.
Tel
--
Fax
--
Country
India
ProdList
102
Advantage
58
Medkem Laboratories
Tel
--
Fax
--
Email
info@medkem.com
Country
India
ProdList
295
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Chemsynth Drugs & Pharmaceuticals Pvt Ltd.
Tel
--
Fax
--
Email
info@cdppl.com
Country
India
ProdList
71
Advantage
58
Exim-Pharm International
Tel
--
Fax
--
Email
devdhar65@gmail.com
Country
India
ProdList
112
Advantage
58
Amegh Pharma Pvt., Ltd.
Tel
--
Fax
--
Email
info@amegh.com
Country
India
ProdList
37
Advantage
58
Nakshatra Chemicals
Tel
--
Fax
--
Country
India
ProdList
162
Advantage
58
Indus Pharma Pvt. Ltd
Tel
--
Fax
--
Email
induspharma1974@gmail.com
Country
India
ProdList
3
Advantage
58
Virchow Laboratories Limited
Tel
--
Fax
--
Country
India
ProdList
31
Advantage
58
Anantco Enterprises Pvt., Ltd.
Tel
--
Fax
--
Email
anantco@anantco.com
Country
India
ProdList
71
Advantage
58
Gemini Exports
Tel
--
Fax
--
Email
uiry@geminiexpor
Country
India
ProdList
140
Advantage
58
Aligns International
Tel
--
Fax
--
Email
info@aligns.in
Country
India
ProdList
137
Advantage
58
Manlax Lifesciences Inc.
Tel
--
Fax
--
Email
manlaxinc@gmail.com
Country
India
ProdList
33
Advantage
58
Pioneer Bio-Pharma Pvt., Ltd
Tel
--
Fax
--
Country
India
ProdList
24
Advantage
58
KOPRAN RESEARCH LABORATORIES LIMITED
Tel
--
Fax
--
Email
info@kopran.com
Country
India
ProdList
8
Advantage
58
Anika International Pvt. Limited
Tel
--
Fax
--
Email
info@anika.in
Country
India
ProdList
94
Advantage
58
Kylsans Drugs & Chemicals (P) Ltd.
Tel
--
Fax
--
Email
info@kylsans.com
Country
India
ProdList
37
Advantage
58
Ster Chem
Tel
--
Fax
--
Email
sterchem@hotmail.com
Country
India
ProdList
14
Advantage
58
Avience chemicals and pharmaceuticals
Tel
--
Fax
--
Email
expoavience@gmail.com
Country
India
ProdList
180
Advantage
58
Sachem
Tel
--
Fax
--
Country
India
ProdList
75
Advantage
58
Rumit International (part of Rumit Group of Companies)
Tel
--
Fax
--
Email
krunali@rumit.in
Country
India
ProdList
75
Advantage
58
Espee Pharmachem Pvt., Ltd.
Tel
--
Fax
--
Email
info@bulkdrugindia.com
Country
India
ProdList
50
Advantage
58
Maas Pharma Chemicals
Tel
--
Fax
--
Email
info@maaspharmachemicals.com
Country
India
ProdList
1607
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Metro Exporters Pvt. Ltd.
Tel
--
Fax
--
Email
metro@metroexporters.net
Country
India
ProdList
204
Advantage
58
Farmachem Life Pvt Ltd
Tel
--
Fax
--
Email
sales@farmachem.co.in
Country
India
ProdList
41
Advantage
58
Megha Health Care Pvt., Ltd.
Tel
--
Fax
--
Email
meghahealthcare@hotmail.com
Country
India
ProdList
126
Advantage
58
Reva Pharmachem (P) Ltd.
Tel
--
Fax
--
Email
info@revapharma.com
Country
India
ProdList
31
Advantage
58
Nest Life Science Pvt., Ltd.
Tel
--
Fax
--
Email
nestlifescience@yahoo.in
Country
India
ProdList
26
Advantage
58
Dilipkumar & Co
Tel
--
Fax
--
Email
zaverip@dilipkumarandco.com
Country
India
ProdList
49
Advantage
58
Atlanta Associates
Tel
--
Fax
--
Country
India
ProdList
184
Advantage
58
Rioth Healthcare Private Limited
Tel
--
Fax
--
Email
bobby@riothhealthcare.com
Country
India
ProdList
35
Advantage
58
Mulji Mehta Pharma
Tel
--
Fax
--
Country
India
ProdList
134
Advantage
58
Bhawanishankar Co. (Divs Laboratories Ltd.)
Tel
--
Fax
--
Email
marketing@divslabs.com
Country
India
ProdList
100
Advantage
58
M S Pharmachem
Tel
--
Fax
--
Email
sunil@mspharmachem.com
Country
India
ProdList
56
Advantage
58
Anand Agencies
Tel
--
Fax
--
Email
en@gmail.com
Country
India
ProdList
2332
Advantage
58
Vitus Global Inc
Tel
--
Fax
--
Email
info@vitusglobalinc.com
Country
India
ProdList
91
Advantage
58
Indogulf Group
Tel
--
Fax
--
Email
info@indogulfgroup.com
Country
India
ProdList
249
Advantage
58
Pluto International
Tel
--
Fax
--
Country
India
ProdList
57
Advantage
58
M/s GMS Lubricants
Tel
--
Fax
--
Country
India
ProdList
1
Advantage
58
Triveni Interchem Private Limited (Group Of Triveni...
Tel
--
Fax
--
Country
India
ProdList
497
Advantage
58
Leotus Enterprises
Tel
--
Fax
--
Country
India
ProdList
48
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
More
Less

View Lastest Price from Cefotaxime sodium manufacturers

Hebei Saisier Technology Co., LTD
Product
Cefotaxime sodium 64485-93-4
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-25
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Cefotaxime sodium 64485-93-4
Price
US $0.00/kg
Min. Order
5kg
Purity
≥85%
Supply Ability
5tons
Release date
2024-04-24
Hebei Mujin Biotechnology Co.,Ltd
Product
Cefotaxime Sodium 64485-93-4
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000KG
Release date
2023-09-05

64485-93-4, Cefotaxime sodiumRelated Search:

Diclofenac sodium Sodium acetate Sodium citrate Sodium chloride Sodium hydroxide Sodium bicarbonate 2-(2-Aminothiazol-4-yl)glyoxylic acid Cefotaxime Trisodium phosphate Acetaminophen Cephalothin sodium Ceftriaxone sodium Ceftiofur sodium Ceftiofur Cephalothin 5-Formamide-1-(2-formyloxyethl)pyrazole 7-Amino-3-cephem-4-carboxylic acid 2-Acetamidoacrylic acid

  • Cefotaxime：Claforan
  • FIR-756
  • (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Cefotaxime sodium salt,Cefotaxim sodium salt
  • Cefotaxime Sodium (350 mg)
  • Cefotaxime Sodium (250 mg)J0C189901ug/mg(ai)
  • Cefotaxime Sodium (250 mg)
  • CefotaxiMe sodiuM API
  • CefotaxiMe sodiuM(Claforan
  • CefotaxiMe-Na-salt research grade
  • Cefotaxime for peak identification
  • AXIME SODIUM SALT
  • Cefotaxime Sodium for Injection
  • CEFOTAXIME NA-SALT
  • CEFOTAXIME SODIUM
  • CEFOTAXIME SODIUM SALT
  • CEFOTAXIM SODIUM SALT
  • CLAFORAN
  • ctx
  • Cefotaxime, Sodium Salt, High Purity, Cell Culture-Tested
  • (((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-,(6r-(6-alpha,7-beta
  • (z))),sodiumsalt
  • 2,0)oct-2-ene-2-carboxylicacid,3-((acetyloxy)methyl)-7-5-thia-1-azabicyclo(
  • 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-,[6R-(6-.alpha.,7-.beta.(Z))],sodiumsalt
  • hr756
  • ru24756
  • sodium7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
  • sodium salt of 7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7 (Z)-(O-methyloxime), acetate (ester)
  • CEFOTAXIME SODIUM STERILE
  • sodium [6R-[6alpha,7beta(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 7-[2-(2-AMINO-4-THIAZOLYL)GLYOXYLAMIDO]-3-(HYDROXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE 7(2)-(Z)-(O-METHYLOXIME) ACETATE, NA
  • [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
  • Cefotaxime sodium sterile USP/EP/JP
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 3-(acetyloxy)methyl-7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-8-oxo-, monosodium salt, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, [6R-[6α,7β(Z)]]-
  • Cefotax
  • Chemcef
  • Pretor
  • Sodium cefotaxime
  • Tolycar
  • Cefotaxime Na
  • Cefotaxime free acid
  • Cefotaxime sodium sterile IP/Bp
  • CEFOTAXIME, SODIUM PLANT CELLCULTURE TES TED
  • CefotaximeSodiumSterileUsp24
  • (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt
  • [6R-[6α，7β(Z)]]-3-[(Acetyloxy)methyl]-7-[2-(2-amino-4-thiazolvl)-2-(methoxyimino)aeetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Sodium salt (syn-isomer)
  • Cefotaxime (Drug Substance)
  • Ceftazidime Solution, 100ppm
  • Cefotaxime sodium salt, 92%, a third-generation cephalosporin antibiotic
  • Pharmaceutical Raw Material Cefotaxime Sodium Cas:64485-93-4
  • ([6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
  • Cefotaxime sodium salt, ≥98%（HPLC)
  • sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • HR-756 (sodium salt)
  • Cefotaxime for peak identification CRS