2-[(Diphenylmethyl)thio]acetic acid

Product Name: 2-[(Diphenylmethyl)thio]acetic acid
CAS No.: 63547-22-8
Chemical Name: 2-[(Diphenylmethyl)thio]acetic acid
Synonyms: AKOS BC-179;AKOS BC-1797;ArModafinil IMpurity B;(BENZHYDRYLTHIO)ACETIC ACID;2-(benzhydrylthio)acetic acid;(Benzhydrylthio)aceticAcid>BENZHYDRYLSULFANYL ACETIC ACID;2-PHENYL METHYLTHIO ACETIC ACID;2-[(diphenylmethyl)thio]acetate;2-[(DIPHENYLMETHYL)THIO]ACETIC ACID
CBNumber: CB2211062
Molecular Formula: C15H14O2S
Formula Weight: 258.34
MOL File: 63547-22-8.mol

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2-[(Diphenylmethyl)thio]acetic acid Property

Melting point:: 127-1290C
Boiling point:: 408.6±33.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
pka: 3.68±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C15H14O2S/c16-14(17)11-18-15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H,16,17)
InChIKey: HTHFEDOFDBZPRX-UHFFFAOYSA-N
SMILES: C(O)(=O)CSC(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference: 63547-22-8(CAS DataBase Reference)

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Safety

HS Code: 2930.90.2900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4175
Product name: (Benzhydrylthio)acetic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $111
Updated: 2025/07/31

TCI Chemical

Product number: B4175
Product name: (Benzhydrylthio)acetic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $335
Updated: 2025/07/31

TRC

Product number: D491830
Product name: 2-[(Diphenylmethyl)thio]aceticAcid
Packaging: 5g
Price: $580
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22503
Product name: 2-[(Diphenylmethyl)thio]acetic acid
Packaging: 5G
Price: $660.7
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22503
Product name: 2-[(Diphenylmethyl)thio]acetic acid
Packaging: 10g
Price: $1201.2
Updated: 2021/12/16

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2-[(Diphenylmethyl)thio]acetic acid Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Powder

Uses

Intermediate in the preparation of Modafinil

Synthesis

91-01-0

68-11-1

63547-22-8

General procedure for the synthesis of 2-[(diphenylmethyl)mercapto]acetic acid from diphenylmethanol and mercaptoacetic acid: mercaptoacetic acid (10.5 g, 7.92 mL, density = 1.325 g/mL, 0.114 mol) was added slowly and dropwise to a solution of trifluoroacetic acid (100 mL) in diphenylmethanol. During the dropwise addition, precipitate formation was observed within 30 minutes. The reaction mixture was stirred continuously for 3 hours at room temperature. Upon completion of the reaction, the precipitate was collected by filtration and washed sequentially with water (3 x 50 mL) and hexane. The crude product was purified by recrystallization from EtOAc/hexane mixed solvent to give colorless crystals of 2-[(diphenylmethyl)thio]acetic acid. Yield: 17.93 g (64% yield). Melting point: 121°C.

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 20, p. 2984 - 2997
[2] Tetrahedron Asymmetry, 2004, vol. 15, # 6, p. 1053 - 1058
[3] Tetrahedron Asymmetry, 2005, vol. 16, # 21, p. 3507 - 3511
[4] Patent: US7553646, 2009, B2
[5] Molecules, 2012, vol. 17, # 9, p. 10446 - 10458

2-[(Diphenylmethyl)thio]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(Diphenylmethyl)thio]acetic acid Suppliers

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View Lastest Price from 2-[(Diphenylmethyl)thio]acetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-[(Diphenylmethyl)thio]acetic acid 63547-22-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-06

Career Henan Chemical Co

Product: 2-[(Diphenylmethyl)thio]acetic acid 63547-22-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

63547-22-8, 2-[(Diphenylmethyl)thio]acetic acidRelated Search:

Mercaptoacetic acid Calcium thioglycolate POTASSIUM THIOGLYCOLATE Ammonium thioglycolate Sodium thioglycolate Methyl thioglycolate Thiosalicylic acid Ethyl 2-(Chlorosulfonyl)acetate 2-Ethylhexyl mercaptoacetate Phenylacetic acid Acetic anhydride (METHYLTHIO)ACETIC ACID Modafinil Carboxylate-d5 Methyl Ester 2-Benzhydrylsulphinylacetic acid ACETIC ACID, [(DIPHENYLMETHYL)SULFINYL]-, ETHYL ESTER Modafinil Carboxylate-d5 Modafinil Carboxylate Methyl Ester (Diphenylmethyl)Thio Acetic Acid Ethyl Ester

2-PHENYL METHYLTHIO ACETIC ACID

2-[(DIPHENYLMETHYL)THIO]ACETIC ACID

AKOS BC-1797

2-(Diphenylmethyl)sulfide acetic acid

BENZHYDRYLSULFANYL ACETIC ACID

(BENZHYDRYLTHIO)ACETIC ACID

AKOS BC-179

Acetic acid, [(diphenylmethyl)thio]-

2-(benzhydrylthio)acetic acid

Acetic acid, [(diphenylMethyl)thio]- (9CI)

ArModafinil IMpurity B

2-[(diphenylmethyl)thio]acetate

2-[(diphenylmethyl)sulfanyl]acetic acid

(Benzhydrylthio)aceticAcid&gt

Acetic acid, 2-[(diphenylmethyl)thio]-

Armodafinil Impurity 3/(2-benzhydryl thio)acetic acid

2-[(DiphenyI Methyl) Thio] Acetic Acid

63547-22-8

62547-22-8

C15H14O2S

Aromatics Compounds

Benzene series

Aromatics

Sulfur & Selenium Compounds