2-Fluoro-4-hydroxybenzaldehyde
- Product Name
- 2-Fluoro-4-hydroxybenzaldehyde
- CAS No.
- 348-27-6
- Chemical Name
- 2-Fluoro-4-hydroxybenzaldehyde
- Synonyms
- 3-Fluoro-4-formylphenol;2-Fluoro-6-nitroacetophenone;2-FLURO-4-HYDROXYBENZALDEHYDE;2-FLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-4-hydroxy-;2-Fluoro-4-hydroxybenzaldehyde,98%
- CBNumber
- CB2214861
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 348-27-6.mol
2-Fluoro-4-hydroxybenzaldehyde Property
- Melting point:
- 168-170°C
- Boiling point:
- 254.2±20.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline powder
- pka
- 6.78±0.18(Predicted)
- color
- Light tan
- InChI
- InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H
- InChIKey
- ONRPXRPUBXXCCM-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(O)C=C1F
- CAS DataBase Reference
- 348-27-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41-52
- Safety Statements
- 26-39
- Hazard Note
- Irritant
- HS Code
- 2912490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H26218
- Product name
- 2-Fluoro-4-hydroxybenzaldehyde, 97%
- Packaging
- 100mg
- Price
- $99.65
- Updated
- 2024/03/01
- Product number
- H26218
- Product name
- 2-Fluoro-4-hydroxybenzaldehyde, 97%
- Packaging
- 500mg
- Price
- $292.65
- Updated
- 2024/03/01
- Product number
- F597973
- Product name
- 2-Fluoro-4-hydroxybenzaldehyde
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 072823
- Product name
- 2-Fluoro-4-hydroxybenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- HCH0019786
- Product name
- 2-FLUORO-4-HYDROXYBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $126
- Updated
- 2021/12/16
2-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production
Uses
2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.
Uses
2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.
Synthesis
Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.
2-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-4-hydroxybenzaldehyde Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
View Lastest Price from 2-Fluoro-4-hydroxybenzaldehyde manufacturers
- Product
- 2-Fluoro-4-hydroxybenzaldehyde 348-27-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-29
- Product
- 2-Fluoro-4-hydroxybenzaldehyde 348-27-6
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Fluoro-4-hydroxybenzaldehyde 348-27-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-07-27