ChemicalBook > CAS DataBase List > 2-Fluoro-4-hydroxybenzaldehyde

2-Fluoro-4-hydroxybenzaldehyde

Product Name
2-Fluoro-4-hydroxybenzaldehyde
CAS No.
348-27-6
Chemical Name
2-Fluoro-4-hydroxybenzaldehyde
Synonyms
3-Fluoro-4-formylphenol;2-Fluoro-6-nitroacetophenone;2-FLURO-4-HYDROXYBENZALDEHYDE;2-FLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-4-hydroxy-;2-Fluoro-4-hydroxybenzaldehyde,98%
CBNumber
CB2214861
Molecular Formula
C7H5FO2
Formula Weight
140.11
MOL File
348-27-6.mol
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2-Fluoro-4-hydroxybenzaldehyde Property

Melting point:
168-170°C
Boiling point:
254.2±20.0 °C(Predicted)
Density 
1.350±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
crystalline powder
pka
6.78±0.18(Predicted)
color 
Light tan
InChI
InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H
InChIKey
ONRPXRPUBXXCCM-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(O)C=C1F
CAS DataBase Reference
348-27-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-37/38-41-52
Safety Statements 
26-39
Hazard Note 
Irritant
HS Code 
2912490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H26218
Product name
2-Fluoro-4-hydroxybenzaldehyde, 97%
Packaging
100mg
Price
$99.65
Updated
2024/03/01
Alfa Aesar
Product number
H26218
Product name
2-Fluoro-4-hydroxybenzaldehyde, 97%
Packaging
500mg
Price
$292.65
Updated
2024/03/01
TRC
Product number
F597973
Product name
2-Fluoro-4-hydroxybenzaldehyde
Packaging
100mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
072823
Product name
2-Fluoro-4-hydroxybenzaldehyde
Purity
95+%
Packaging
5g
Price
$69
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0019786
Product name
2-FLUORO-4-HYDROXYBENZALDEHYDE
Purity
95.00%
Packaging
250MG
Price
$126
Updated
2021/12/16
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2-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Uses

2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

Uses

2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.

Synthesis

Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.

2-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-hydroxybenzaldehyde Suppliers

China 160 France 1 Germany 5 India 6 Italy 1 The Netherlands 1 United Kingdom 16 United States 31 Global 221
Ark Pharm, Inc.
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View Lastest Price from 2-Fluoro-4-hydroxybenzaldehyde manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Fluoro-4-hydroxybenzaldehyde 348-27-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-29
Henan Fengda Chemical Co., Ltd
Product
2-Fluoro-4-hydroxybenzaldehyde 348-27-6
Price
US $34.00-1.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Hebei Mojin Biotechnology Co., Ltd
Product
2-Fluoro-4-hydroxybenzaldehyde 348-27-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-27

348-27-6, 2-Fluoro-4-hydroxybenzaldehydeRelated Search:

4-Hydroxybenzaldehyde Benzaldehyde Salicylaldehyde 3-(Trifluoromethyl)benzaldehyde 2-(Trifluoromethyl)benzaldehyde 3-Hydroxybenzaldehyde 2-Fluoro-4-hydroxybenzoic acid 2-Fluoro-4-methylbenzoic acid 3-FLUORO-4-HYDROXYBENZALDEHYDE Fluorine 2-Fluoro-4-methoxyacetophenone 2,3,5,6-Tetrafluoro-4-hydroxy-benzoic acid 2'-Fluoro-4'-hydroxyacetophenone 6-FLUOROVERATRALDEHYDE 3-FLUORO-2-HYDROXYBENZALDEHYDE,3-Fluoro-2-Hydroxybenzaldehyde 3-Fluoro Salicylaldehyde,3-Fluoro-2-hydroxybenzaldehyde ,99% 2-FLUORO-5-HYDROXYBENZALDEHYDE 5-Fluorosalicylaldehyde 3,5-Difluoro-4-hydroxybenzaldehyde

  • 2-FLUORO-4-HYDROXYBENZALDEHYDE
  • 2-FLURO-4-HYDROXYBENZALDEHYDE
  • 2-Fluoro-4-hydroxybenzaldehyde,98%
  • 3-Fluoro-4-formylphenol
  • Benzaldehyde, 2-fluoro-4-hydroxy-
  • 2-Fluoro-6-nitroacetophenone
  • 348-27-6
  • C7H5O2F
  • Aromatic Aldehydes & Derivatives (substituted)
  • API intermediates