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Ethyl bromodifluoroacetate

Product Name
Ethyl bromodifluoroacetate
CAS No.
667-27-6
Chemical Name
Ethyl bromodifluoroacetate
Synonyms
2-broMo-2,2-difluoroacetate;EBDA;2-Bromo-2,2-difluoroacetic acid ethyl ester;EBFA;bromodifL;Ethyl bromodifluoroa;Ethylbromdifluoracetat;Twoethyl broMidefluoride;ETHYL BROMODIFLUOROACETATE;difluorobromo ethyl acetate
CBNumber
CB2238865
Molecular Formula
C4H5BrF2O2
Formula Weight
202.98
MOL File
667-27-6.mol
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Ethyl bromodifluoroacetate Property

Boiling point:
112 °C/700 mmHg (lit.)
Density 
1.583 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.387(lit.)
Flash point:
70 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in most organic solvents.
form 
Liquid
color 
Clear colorless to slightly yellow
Specific Gravity
1.583
BRN 
1906095
InChI
InChI=1S/C4H5BrF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
InChIKey
IRSJDVYTJUCXRV-UHFFFAOYSA-N
SMILES
C(OCC)(=O)C(Br)(F)F
CAS DataBase Reference
667-27-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl bromodifluoroacetate(667-27-6)
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Safety

Hazard Codes 
C,F,Xi
Risk Statements 
10-34-36
Safety Statements 
26-36/37/39-45-16-27
RIDADR 
UN 2924 3/PG 2
WGK Germany 
3
Hazard Note 
Irritant/Flammable
TSCA 
No
HazardClass 
3
PackingGroup 
II
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
295795
Product name
Ethyl bromodifluoroacetate
Purity
98%
Packaging
5g
Price
$72.2
Updated
2024/03/01
TCI Chemical
Product number
B1463
Product name
Ethyl Bromodifluoroacetate
Purity
>98.0%(GC)
Packaging
5g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
B1463
Product name
Ethyl Bromodifluoroacetate
Purity
>98.0%(GC)
Packaging
25g
Price
$53
Updated
2024/03/01
Alfa Aesar
Product number
B20461
Product name
Ethyl bromodifluoroacetate, 97%
Packaging
5g
Price
$65.65
Updated
2024/03/01
TCI Chemical
Product number
B1463
Product name
Ethyl Bromodifluoroacetate
Purity
>98.0%(GC)
Packaging
250g
Price
$306
Updated
2024/03/01
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Ethyl bromodifluoroacetate Chemical Properties,Usage,Production

Description

Ethyl bromodifluoroacetate, a clear to yellow liquid, is an ester of bromodifluoroacetic acid and ethyl alcohol. It is an ester that can be used to introduce the CF2 group when synthesizing chemical compounds. Ethyl bromdifluoroacetate is considered to be a good compound in the generation of compounds and for testing with other organic compounds like lactones, imines, and other amino acids.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

Ethyl bromodifluoroacetate, is used for the treatment of the Reformat sky reagent with aldehydes and ketones affords 2,2-difluoro-3-hydroxy esters. It is also used in the analysis of reagent purity through IR, NMR.

Uses

Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis. A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF2CO2Et) as a difluoroacetylating reagent.

Uses

Ethyl bromodifluoroacetate is usually used in the preparation of substituted ethyl 2′-pyridyldifluoroacetates,4-alkoxymethyl- and 4-aryloxymethyl-3,3-difluoropiperidines,α,α-difluoro-β-lactams,mono- and difluoromethylated phenanthridine derivatives.

Preparation

Difluorobromoacetonitrile is taken as a raw material, and prepared through a one-pot method and subjected to alcoholysis and esterification in ethanol aqueous solution to obtain ethyl bromodifluoroacetate.Reaction equation is:
BrF2CCN→BrF2CCOOH→BrF2CCOOC2H5

Ethyl bromodifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl bromodifluoroacetate Suppliers

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View Lastest Price from Ethyl bromodifluoroacetate manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Ethyl bromodifluoroacetate 667-27-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethyl bromodifluoroacetate 667-27-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-23
Career Henan Chemical Co
Product
Ethyl bromodifluoroacetate 667-27-6
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-21

667-27-6, Ethyl bromodifluoroacetateRelated Search:

Difluoroacetic acid Ethyl difluoroacetate BROMODIFLUOROACETIC ACID METHYL BROMODIFLUOROACETATE Cuprous iodide Sulfuryl chloride Hydrazine sulfate Sodium ascorbate METHYL DIFLUOROACETATE Sodium chlorodifluoroacetate Diethyl 2,2-difluoromalonate Chlorodifluoroacetic acid ethyl ester 2-(2-Aminoethoxy)ethanol Bromoacetic acid Ethyl fluoroacetate Ethyl bromofluoroacetate Ethyl bromodifluoroacetate Ethyl bromoacetate

  • ETHYL BROMODIFLUOROACETATE
  • BROMODIFLUOROACETIC ACID ETHYL ESTER
  • 2-Bromo-2,2-difluoroacetic acid ethyl ester
  • Difluorobromoacetic acid ethyl ester
  • Ethyl 2,2-Difluoro-2-Bromoac
  • Ethyl bromodifluoroa
  • 2-Bromo-2,2-difluoro-1-ethoxyethan-1-one, 2-Bromo-2,2-difluoro-1-ethoxy-1-oxoethane
  • Ethyl broModifluoroacetate, 98% 5GR
  • Ethylbromdifluoracetat
  • 2-broMo-2,2-difluoroacetate
  • 2-Bromo-2,2-difluoro-1-ethoxyethan-1-one, 2-Bromo-2,2-difluoro-1-ethoxy-1-oxoethane, Bromo(difluoro)acetic acid ethyl ester
  • Twoethyl broMidefluoride
  • Ethyl broMoacetatetwo fluorine
  • Acetic acid, bromodifluoro-, ethyl ester
  • 2,2-difluoro-2-bromoacetate ethyl
  • Ethyl bromodifluoroacetate 98%
  • difluorobromo ethyl acetate
  • Ethylbromodifluoroacetate98%
  • Acetic acid, 2-bromo-2,2-difluoro-, ethyl ester
  • Ethyl 2,2-difluoro-2-bromoacetate
  • Ethyl Bromodifluoroacetate &gt
  • Ethyl Bromodifluoroacetate,99%
  • bromodifL
  • TIANFU CHEM---Ethyl bromodifluoroacetate
  • EBDA
  • Ethyl bromoacetate difluoro
  • EBFA
  • 667-27-6
  • C4H5BrF2O2
  • BrCF2COOCH2CH3
  • BrCF2CO2CH2CH3
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  • Organic Building Blocks
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  • Carbonyl Compounds
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  • Chemical Synthesis
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  • Organic Fluorinated Building Blocks
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  • C2 to C5
  • Carbonyl Compounds
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  • API intermediates
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