Ethyl 2-acetyl-3-(dimethylamino)acrylate

Product Name: Ethyl 2-acetyl-3-(dimethylamino)acrylate
CAS No.: 51145-57-4
Chemical Name: Ethyl 2-acetyl-3-(dimethylamino)acrylate
Synonyms: Leflunomide Impurity 8;ETHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE;Ethyl2-acetyl-3-(dimethylamino)acrylate,95%;ethyl (2z)-2-acetyl-3-(dimethylamino)acrylate;ETHYL N, N-DIMETHYLAMINOMETHYLENE ACETOACETATE;Ethyl 2-[(dimethylamino)methylene]acetoacetate;2-ACETYL-3-DIMETHYLAMINO-ACRYLIC ACID ETHYL ESTER;ethyl 2-[(diMethylaMino)Methylidene]-3-oxobutanoate;Ethyl 2-[(dimethylamino)methylene]-3-oxo-Butanoicate;(E)-ethyl 2-((diMethylaMino)Methylene)-3-oxobutanoate
CBNumber: CB2239716
Molecular Formula: C9H15NO3
Formula Weight: 185.22
MOL File: 51145-57-4.mol

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Ethyl 2-acetyl-3-(dimethylamino)acrylate Property

Melting point:: 41-44 °C(Solv: isopropyl ether (108-20-3))
Boiling point:: 128°C 0,2mm
Density: 1.038±0.06 g/cm3(Predicted)
refractive index: 1.5330-1.5370
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 3.52±0.70(Predicted)
form: Liquid
color: Pale red
λmax: 304nm(EtOH(95vol%))(lit.)
CAS DataBase Reference: 51145-57-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
Safety Statements: 26-36/37/39-45-23
RIDADR: UN2735
HazardClass: IRRITANT
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1179
Product name: Ethyl 2-Acetyl-3-(dimethylamino)acrylate
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: E1179
Product name: Ethyl 2-Acetyl-3-(dimethylamino)acrylate
Purity: >95.0%(GC)(T)
Packaging: 25g
Price: $152
Updated: 2025/07/31

TRC

Product number: E916625
Product name: Ethyl2-Dimethylaminomethylene-3-oxobutanoate
Packaging: 250g
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0029560
Product name: ETHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE
Purity: 95.00%
Packaging: 1G
Price: $671.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0029560
Product name: ETHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE
Purity: 95.00%
Packaging: 5G
Price: $988.33
Updated: 2021/12/16

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Ethyl 2-acetyl-3-(dimethylamino)acrylate Chemical Properties,Usage,Production

Chemical Properties

Yellow Oil

Uses

Ethyl 2-Dimethylaminomethylene-3-oxobutanoate (cas# 51145-57-4) is a compound useful in organic synthesis.

Synthesis

141-97-9

4637-24-5

134653-70-6

The general procedure for the synthesis of ethyl (Z)-2-((dimethylamino)methylene)-3-oxobutanoate from ethyl acetoacetate and N,N-dimethylformamide dimethyl acetal was as follows: referring to Example 75, ethyl acetoacetate (79 mL, 0.62 mol) was added to N,N-dimethylformamide dimethyl acetal (100 mL, 0.68 mol) and the mixture was heated to reflux for 1 hour. Upon completion of the reaction, the excess acetal was removed by subtractive distillation, followed by subtractive distillation of the residue to afford the target product (Z)-ethyl (Z)-2-((dimethylamino)methylene)-3-oxobutanoate (85 g, 74% yield). The boiling point of the product was 125-130 °C (400 Pa).1H-NMR (CDCl3) δ: 1.33 (3H, t, J = 7.1 Hz), 2.33 (3H, s), 3.04 (6H, br s), 4.23 (2H, q, J = 7.1 Hz), 7.68 (1H, s).

References

[1] Patent: WO2006/73361, 2006, A1. Location in patent: Page/Page column 147
[2] Patent: US2007/244088, 2007, A1. Location in patent: Page/Page column 38
[3] Patent: US2008/9523, 2008, A1. Location in patent: Page/Page column 18; 19
[4] Patent: WO2008/4943, 2008, A1. Location in patent: Page/Page column 59
[5] Patent: WO2008/4942, 2008, A1. Location in patent: Page/Page column 56

Ethyl 2-acetyl-3-(dimethylamino)acrylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-acetyl-3-(dimethylamino)acrylate Suppliers

Americas 1 Belgium 1 Canada 1 China 116 Europe 1 Germany 2 India 5 Japan 3 Poland 1 Switzerland 1 United Kingdom 11 United States 29 Global 172

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View Lastest Price from Ethyl 2-acetyl-3-(dimethylamino)acrylate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ethyl 2-acetyl-3-(dimethylamino)acrylate 51145-57-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-11

Career Henan Chemical Co

Product: Ethyl 2-acetyl-3-(dimethylamino)acrylate 51145-57-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

51145-57-4, Ethyl 2-acetyl-3-(dimethylamino)acrylateRelated Search:

3-Dimethylaminopropylamine Acetyl chloride Ethylparaben Acetylacetone Ethyl methacrylate Ethyl acetate Ethyl acrylate ETHYL 2-CYANOACRYLATE 2-Hydroxyethyl acrylate 2-Hydroxyethyl methacrylate Ethanol ISOXADIFEN-ETHYL POLY(ETHYL METHACRYLATE) POLY(ETHYL ACRYLATE) Ethyl cyanoacetate Trinexapac-ethyl N,N-Dimethyl-1,4-phenylenediamine Ethyl propiolate

2-ACETYL-3-DIMETHYLAMINO-ACRYLIC ACID ETHYL ESTER

ETHYL 2-ACETYL-3-(DIMETHYLAMINO)ACRYLATE

ETHYL N, N-DIMETHYLAMINOMETHYLENE ACETOACETATE

Ethyl (2E)-2-(dimethylaminomethylidene)-3-oxobutanoate

ethyl (2z)-2-acetyl-3-(dimethylamino)acrylate

Ethyl 2-[(dimethylamino)methylene]-3-oxo-Butanoicate

Ethyl 2-[(dimethylamino)methylene]acetoacetate

Ethyl 2-acetyl-3-(dimethylamino)acrylate, Ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate, Ethyl 2-[(dimethylamino)methylidene]-3-oxobutanoate

2-[(DiMethylaMino)Methylene]-3-oxo-butanoic Acid Ethyl Ester

(E)-ethyl 2-((diMethylaMino)Methylene)-3-oxobutanoate

ethyl 2-[(diMethylaMino)Methylidene]-3-oxobutanoate

Leflunomide Impurity 8

Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, ethyl ester

Ethyl2-acetyl-3-(dimethylamino)acrylate,95%

Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, ethyl ester (9CI, ACI)

2-[(dimethylamino)methylene]-3-oxo-Butanoic acid ethyl ester (9CI ACI)

51145-57-4

Aliphatics

Esters

API intermediates

Miscellaneous Reagents