ChemicalBook > CAS DataBase List > RS 23597-190 HYDROCHLORIDE

RS 23597-190 HYDROCHLORIDE

Product Name
RS 23597-190 HYDROCHLORIDE
CAS No.
149719-06-2
Chemical Name
RS 23597-190 HYDROCHLORIDE
Synonyms
RS23597-190HCl;RS 23597-190 hydroch;RS 23597-190 >=98% (HPLC);RS 23597-190 HYDROCHLORIDE;RS 23597 190 hydrochloride,RS 23597190 hydrochloride;3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL;3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE;3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride;3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
CBNumber
CB2242093
Molecular Formula
C16H24Cl2N2O3
Formula Weight
363.28
MOL File
149719-06-2.mol
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RS 23597-190 HYDROCHLORIDE Property

storage temp. 
Sealed in dry,2-8°C
solubility 
Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM)
form 
Powder
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1909
Product name
RS 23597-190
Purity
≥98% (HPLC)
Packaging
5MG
Price
$102
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1909
Product name
RS 23597-190
Purity
≥98% (HPLC)
Packaging
25MG
Price
$376
Updated
2022/05/15
Tocris
Product number
0728
Product name
RS23597-190hydrochloride
Packaging
50
Price
$411
Updated
2021/12/16
Tocris
Product number
0728
Product name
RS23597-190hydrochloride
Packaging
10
Price
$98
Updated
2021/12/16
TRC
Product number
R700958
Product name
RS23597-190Hydrochloride
Packaging
5mg
Price
$420
Updated
2021/12/16
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RS 23597-190 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.

Biological Activity

A high affinity, selective competitive antagonist at 5-HT 4 receptors.

Biochem/physiol Actions

RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).

storage

Store at RT

RS 23597-190 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

149719-06-2, RS 23597-190 HYDROCHLORIDERelated Search:


  • 3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
  • 3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride
  • 4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
  • 3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL
  • 3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE
  • RS 23597-190 HYDROCHLORIDE
  • RS23597-190HCl
  • 4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester hydrochloride
  • RS 23597-190 >=98% (HPLC)
  • RS 23597-190 hydroch
  • Benzoic acid, 4-amino-5-chloro-2-methoxy-, 3-(1-piperidinyl)propyl ester, hydrochloride (1:1)
  • 4-amino-5-chloro-2-methoxy-Benzoic acid 3-(1-piperidinyl)propyl ester hydrochloride (1:1)
  • RS 23597 190 hydrochloride,RS 23597190 hydrochloride
  • 149719-06-2
  • C16H24Cl2N2O3
  • C16H23ClN2O3HCl