RS 23597-190 HYDROCHLORIDE
- Product Name
- RS 23597-190 HYDROCHLORIDE
- CAS No.
- 149719-06-2
- Chemical Name
- RS 23597-190 HYDROCHLORIDE
- Synonyms
- RS23597-190HCl;RS 23597-190 hydroch;RS 23597-190 >=98% (HPLC);RS 23597-190 HYDROCHLORIDE;RS 23597 190 hydrochloride,RS 23597190 hydrochloride;3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL;3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE;3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride;3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride
- CBNumber
- CB2242093
- Molecular Formula
- C16H24Cl2N2O3
- Formula Weight
- 363.28
- MOL File
- 149719-06-2.mol
RS 23597-190 HYDROCHLORIDE Property
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM)
- form
- Powder
- Water Solubility
- Soluble to 100 mM in water
N-Bromosuccinimide Price
- Product number
- SML1909
- Product name
- RS 23597-190
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $102
- Updated
- 2023/06/20
- Product number
- SML1909
- Product name
- RS 23597-190
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $376
- Updated
- 2022/05/15
- Product number
- 0728
- Product name
- RS23597-190hydrochloride
- Packaging
- 50
- Price
- $411
- Updated
- 2021/12/16
- Product number
- 0728
- Product name
- RS23597-190hydrochloride
- Packaging
- 10
- Price
- $98
- Updated
- 2021/12/16
- Product number
- R700958
- Product name
- RS23597-190Hydrochloride
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
RS 23597-190 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist.
Biological Activity
A high affinity, selective competitive antagonist at 5-HT 4 receptors.
Biochem/physiol Actions
RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2).
storage
Store at RT