LY411575
- Product Name
- LY411575
- CAS No.
- 209984-57-6
- Chemical Name
- LY411575
- Synonyms
- CS-509;LY411575;LY4114575;LSN-411575;LY411575, >=98%;LY411575;LY 411575;LY-411575 >=97% (HPLC);LY-411575;LY411575; LY 411575;LY411575, 98%, a γ-secretase inhibitor;(S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib
- CBNumber
- CB22464309
- Molecular Formula
- C26H23F2N3O4
- Formula Weight
- 479.48
- MOL File
- 209984-57-6.mol
LY411575 Property
- Boiling point:
- 836.0±65.0 °C(Predicted)
- Density
- 1.40
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear
- pka
- 11.79±0.20(Predicted)
- form
- powder
- color
- white to beige
- InChIKey
- ULSSJYNJIZWPSB-CVRXJBIPSA-N
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0506
- Product name
- LY-411575
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- SML0506
- Product name
- LY-411575
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $514
- Updated
- 2024/03/01
- Product number
- 16162
- Product name
- LY411575
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 16162
- Product name
- LY411575
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 16162
- Product name
- LY411575
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
LY411575 Chemical Properties,Usage,Production
Description
γ-
Uses
LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.
Definition
ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.
Biochem/physiol Actions
LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
target
γ-secretase
LY411575 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from LY411575 manufacturers
- Product
- LY411575 209984-57-6
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 10kg; 25kg
- Release date
- 2020-01-07