N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE
- Product Name
- N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE
- CAS No.
- 5462-30-6
- Chemical Name
- N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE
- Synonyms
- 4,5-DICHLORO-2-NITROACETANILIDE;Dichloro-2-nitro-acetanilide,4,5-;4',5'-Dichloro-2'-nitroacetanilide;4,5-DICHLORO-2-NITRO-N-ACETYLANILINE;N-(4,5-dichloro-2-nitrophenyl)acetamid;N-(4,5-dichloro-2-aminophenyl)Acetamide;N-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE;N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE;4,5 DI CHLORO 2-NITRO ACETANILIDE 98%HPLC;ACETAMIDE, N-(4,5-DICHLORO-2-NITROPHENYL)-
- CBNumber
- CB2251039
- Molecular Formula
- C8H6Cl2N2O3
- Formula Weight
- 249.05
- MOL File
- 5462-30-6.mol
N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE Property
- Melting point:
- 124-128 °C(lit.)
- Boiling point:
- 418.4±45.0 °C(Predicted)
- Density
- 1.573±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 12.29±0.70(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C8H6Cl2N2O3/c1-4(13)11-7-2-5(9)6(10)3-8(7)12(14)15/h2-3H,1H3,(H,11,13)
- InChIKey
- ZEGRPTYRAGSSBH-UHFFFAOYSA-N
- SMILES
- C(NC1=CC(Cl)=C(Cl)C=C1[N+]([O-])=O)(=O)C
- CAS DataBase Reference
- 5462-30-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HS Code
- 2924190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 641715
- Product name
- N-(4,5-Dichloro-2-nitrophenyl)acetamide
- Purity
- 97%
- Packaging
- 5g
- Price
- $90
- Updated
- 2023/01/07
- Product number
- D4907
- Product name
- 4',5'-Dichloro-2'-nitroacetanilide
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- D4907
- Product name
- 4',5'-Dichloro-2'-nitroacetanilide
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $371
- Updated
- 2025/07/31
- Product number
- D436673
- Product name
- N-(4,5-Dichloro-2-nitrophenyl)acetamide
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 084993
- Product name
- N1-(4,5-Dichloro-2-nitrophenyl)acetamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $102
- Updated
- 2021/12/16
N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE Chemical Properties,Usage,Production
Synthesis
2150-93-8
5462-30-6
The general procedure for the synthesis of N1-(4,5-dichloro-2-nitrophenyl)acetamide from N-(3,4-dichlorophenyl)acetamide was as follows: 3,4-dichloroacetanilide (II) (150 g, 0.74 mol) was slowly added to a reactor containing sulfuric acid (270 g, 99%, 2.7 mol) at 13 °C, stirred for 0.5 h and then cooled to 8 °C. Subsequently, fuming sulfuric acid (422 g, 31.1%, 4.61 mol) was slowly added to obtain a mixture. The sulfuric acid concentration of this mixture was 104%, where the molar ratio of 3,4-dichloroacetanilide (II) to sulfuric acid was 1:10. The mixture was further cooled to 3 °C and nitric acid (51 g, 98%, 0.79 mol) was slowly added over a period of 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC).3,4-Dichloroacetanilide was completely consumed within 1 h to give the product mixture. The product mixture was carefully poured into a mixture of 1650 g of ice with 200 ml of water, maintained at a temperature below 15 °C and stirred for 15 min to form a dispersion. The dispersion was filtered to give a residue containing 2-nitro-4,5-dichloroacetanilide (I). The residue was washed with water until no residual acid remained and dried to give 2-nitro-4,5-dichloroacetanilide (I) (174 g, yield = 95.23%, HPLC purity = 97.83%).HPLC analysis showed that the product contained 1.46% III.
References
[1] Patent: WO2018/91978, 2018, A1. Location in patent: Page/Page column 7-8
[2] Journal of Medicinal Chemistry, 1995, vol. 38, # 10, p. 1786 - 1792
N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE manufacturers
- Product
- N1-(4,5-DICHLORO-2-NITROPHENYL)ACETAMIDE 5462-30-6
- Price
- US $95.00-950.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-09
- Product
- N1-(4,5-Dichloro-2-Nitrophenyl)Acetamide 5462-30-6
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- kg--ton
- Release date
- 2020-03-08