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Gefitinib InterMediate B

Product Name
Gefitinib InterMediate B
CAS No.
912556-91-3
Chemical Name
Gefitinib InterMediate B
Synonyms
Gefitinib InterMediate B;Gefitinib InterMediate B ISO 9001：2015 REACH;N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-4-quinazolinamine;N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-Methoxyquinazolin-4-aMine;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-;6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine
CBNumber
CB22544180
Molecular Formula
C18H16Cl2FN3O2
Formula Weight
396.24
MOL File
912556-91-3.mol
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Gefitinib InterMediate B Property

Melting point:
234-236 °C
Boiling point:
523.3±50.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
5.40±0.30(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0369686
Product name
N-(3-CHLORO-4-FLUOROPHENYL)-6-(3-CHLOROPROPOXY)-7-METHOXYQUINAZOLIN-4-AMINE
Purity
95.00%
Packaging
5MG
Price
$495.2
Updated
2021/12/16
Matrix Scientific
Product number
119973
Product name
N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Purity
95+%
Packaging
250mg
Price
$706
Updated
2021/12/16
AK Scientific
Product number
Z5329
Product name
N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Packaging
1g
Price
$735
Updated
2021/12/16
Matrix Scientific
Product number
119973
Product name
N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Purity
95+%
Packaging
1g
Price
$1764
Updated
2021/12/16
Ambeed
Product number
A105761
Product name
N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine
Purity
97%
Packaging
100mg
Price
$115
Updated
2021/12/16
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Gefitinib InterMediate B Chemical Properties,Usage,Production

Uses

4-Chloro-6-(3-chloropropoxy)-7-methoxyquinazoline is an analogue of Gefitinib, an inhibitor of EGFR with anti-tumor activity.

Synthesis

109-70-6

184475-71-6

912556-91-3

A mixture of 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol (20.00 g), K2CO3 (10.37 g), KI (1.04 g), 1-bromo-3-chloropropane (7.50 mL), and DMF (150 mL) was stirred and reacted for 6 hours at 40 °C. After completion of the reaction, the reaction mixture was poured into water and the solid was collected by filtration. The filtrate was purified by silica gel column chromatography (eluent: ethyl acetate) to afford the target compound, N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine, as a light yellow liquid (22.05 g, 89.00% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 396.1 ([M+H]+); 1H NMR (400 MHz, CDCl3) δ: 2.01 (m, 2H), 3.68 (t, J=4.2 Hz, 2H), 4.00 (s, 3H), 4.10 (t, J=4.2 Hz, 2H). 6.80 (s, 1H), 7.16 (s, 1H), 7.26 (s, 1H), 7.30 (s, 1H), 7.47 (s, 1H), 8.64 (s, 1H) ppm.

References

[1] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00197
[2] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0277-0278
[3] Patent: US2014/206664, 2014, A1. Location in patent: Paragraph 0225; 0229
[4] Patent: EP2796451, 2014, A1. Location in patent: Paragraph 0082

Gefitinib InterMediate B Preparation Products And Raw materials

Raw materials

Preparation Products

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Gefitinib InterMediate B Suppliers

China 48 India 1 United States 4 Global 53
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
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View Lastest Price from Gefitinib InterMediate B manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Gefitinib InterMediate B 912556-91-3
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-17
Career Henan Chemical Co
Product
Gefitinib InterMediate B 912556-91-3
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-10

912556-91-3, Gefitinib InterMediate BRelated Search:

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  • N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-Methoxyquinazolin-4-aMine
  • Gefitinib InterMediate B
  • 6-(3-chloropropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-ylamine
  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-
  • Gefitinib InterMediate B ISO 9001：2015 REACH
  • N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxy-4-quinazolinamine
  • 912556-91-3
  • C18H16Cl2FN3O2