A 967079

Product Name: A 967079
CAS No.: 1170613-55-4
Chemical Name: A 967079
Synonyms: A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
CBNumber: CB22650391
Molecular Formula: C12H14FNO
Formula Weight: 207.24
MOL File: 1170613-55-4.mol

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A 967079 Property

Boiling point:: 324.4±34.0 °C(Predicted)
Density: 1.03±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO: ≥12mg/mL
pka: 12.23±0.40(Predicted)
form: powder
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
InChI: InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
InChIKey: HKROEBDHHKMNBZ-CHBKHGQFSA-N
SMILES: C(/C1=CC=C(F)C=C1)=C(/C)\C(=N\O)\CC

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Safety

WGK Germany: 3
HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0085
Product name: A-967079
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $85.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0085
Product name: A-967079
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $538
Updated: 2024/03/01

Cayman Chemical

Product number: 15207
Product name: A-967079
Purity: ≥98%
Packaging: 5mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 15207
Product name: A-967079
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 15207
Product name: A-967079
Purity: ≥98%
Packaging: 25mg
Price: $286
Updated: 2024/03/01

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A 967079 Chemical Properties,Usage,Production

Description

A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable

Uses

A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.

Uses

(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.

General Description

A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.

Biochem/physiol Actions

A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

storage

+4°C

Advantages

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime (A-967079) has shown impressive efficacy as an antagonist to TRPA1 and has multiple advantages over other compounds, including high selectivity, potency, and oral bioavailability. A-967079 has IC50 values of 67 and 289 nM for human and rat TRPA1 receptors, respectively. It displays 1000-fold selectivity for TRPA1 over other TRP channels, and >150-fold selectivity for over 75 other ion channels, enzymes and G-protein-coupled receptors. Oral administration of A-967079 in rats produced robust bioavailability and analgesic efficacy for TIH-induced pain response (i.e., sneezing, tearing, coughing, etc.) and osteoarthritic pain. Intravenous injection of A-967079 has shown to decrease the reactive gas response of wide dynamic range neurons (i.e., a second-order neuron that responds to more than one type of stimulus) and pain specific-neurons. Aditionally, A-967079 produces no known locomotor or cardiovascular effects, a common side effect of other TRP antagonists[2].

References

[1] McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.
[2] Obed A. Gyamfi . “Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry.” Journal of Pharmaceutical Analysis 10 2 (2020): Pages 157-163.

A 967079 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 967079 Suppliers

Canada 1 China 55 India 1 United Kingdom 1 United States 16 USA 1 Global 75

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View Lastest Price from A 967079 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: A 967079 1170613-55-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99
Supply Ability: 20G
Release date: 2024-07-12

1170613-55-4, A 967079Related Search:

Dofetilide Niguldipine (hydrochloride) 2-Propenoic acid, 3,3'-(1,3-phenylene)bis- VERATRIDINE

A 967079

(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime

1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-

TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079

1170613-55-4

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