1,2,4-Triazole

ChemicalBook > CAS DataBase List > 1,2,4-Triazole

Product Name: 1,2,4-Triazole
CAS No.: 288-88-0
Chemical Name: 1,2,4-Triazole
Synonyms: TRIAZOLE;1H-1,2,4-TRIAZOLE;4H-1,2,4-triazole;1,2,4-1H-TRIAZOLE;1,2,4-Triazol;PYRRODIAZOLE;1H-1,2,4-Triazol;1,2,4-Triazole,99%;TA-4;TAR4
CBNumber: CB2277901
Molecular Formula: C2H3N3
Formula Weight: 69.07
MOL File: 288-88-0.mol

Less

1,2,4-Triazole Property

Melting point:: 119-121 °C (lit.)
Boiling point:: 260 °C (lit.)
Density: 1.15 g/cm3 (130℃)
bulk density: 550kg/m3
vapor pressure: 0.215Pa at 20℃
refractive index: 1.4854 (estimate)
Flash point:: 140 °C
storage temp.: Store below +30°C.
solubility: 547g/l
form: Crystalline Powder and Flakes
pka: 2.27(at 20℃)
color: White
PH: 8 (10g/l, H2O, 20℃)
Water Solubility: 1250 g/L (20 ºC)
Merck: 14,9605
BRN: 104767
InChIKey: NSPMIYGKQJPBQR-UHFFFAOYSA-N
LogP: -0.76 at 25℃
CAS DataBase Reference: 288-88-0(CAS DataBase Reference)
NIST Chemistry Reference: 1H-1,2,4-Triazole(288-88-0)
EPA Substance Registry System: 1,2,4-Triazole (288-88-0)

Less

Safety

Hazard Codes: Xn,Xi,C
Risk Statements: 22-36-63-34
Safety Statements: 36/37-45-36/37/39-27-26
WGK Germany: 2
RTECS: XZ3806000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29339990
Hazardous Substances Data: 288-88-0(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: 1650 mg/kg LD50 dermal Rabbit 3129 - 4200 mg/kg

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T46108
Product name: 1,2,4-Triazole
Purity: 98%
Packaging: 25g
Price: $36.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: T46108
Product name: 1,2,4-Triazole
Purity: 98%
Packaging: 100g
Price: $97.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08388
Product name: 1,2,4-Triazole
Purity: for synthesis
Packaging: 25g
Price: $52.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08388
Product name: 1,2,4-Triazole
Purity: for synthesis
Packaging: 100g
Price: $167
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08388
Product name: 1,2,4-Triazole
Purity: for synthesis
Packaging: 25kg
Price: $1520
Updated: 2024/03/01

Less

1,2,4-Triazole Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder and flakes

Uses

1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959.

Uses

1,2,4-Triazole is used in the production of pesticides, pharmaceuticals (fluconazole), dyes and rubber additives, and also in the photoconductor of replication system. Intermediate of antifungal fluconazole.

Uses

1,2,4-triazole and its derivatives are important structural moieties of many pharmaceutical drugs. Triazoles can also act as ligands to form coordination complexes with transition metal ions. Due to their electron-deficient nature, they exhibit excellent electron-transport and hole-blocking properties, making them promising organic materials in material science applications.

Definition

1,2,4-triazole is a chemical substance with molecular formula C2H3N3, molecular weight 69.07 and CAS No. 288-88-0. Colorless acicular crystal, soluble in water and ethanol. 1H-1,2,4-triazole is a 1,2,4-triazole. It is a tautomer of a 3H-1,2,4-triazole and a 4H-1,2,4-triazole.
Triazole is an aromatic five membered heterocyclic compound. Its unique structure is conducive to the formation of a variety of non covalent bonds and is easy to promote the binding of proteins, enzymes and receptors, thus showing a wide range of biological pharmacological activities, such as anticancer, antispasmodic, antibacterial, anti HIV. In particular, 1,2,3-triazole has strong thermal stability and acid-base stability, and is not sensitive to redox, hydrolysis and enzymatic degradation. It is often used as a pharmacodynamic group in drug synthesis.

Definition

A heterocyclic organic compound with a five-membered ring containing two carbon atoms and three nitrogen atoms. There are two isomers.

Flammability and Explosibility

Non flammable

Synthesis

Alkyl bromide and sodium azide were used as raw materials to prepare organic azides, and a series of 1,2,4-Triazole small molecules were prepared by click chemistry. The structures of the six products were characterized by 1H NMR, 13C NMR and IR. the products were expected targets. Furthermore, the effect of different substituent structure on the reaction was discussed. Especially the introduction of drug molecule ethisterone, which is expected to provide a certain experimental basis for the application of triazole and its derivatives in biomedicine and other fields.
As shown in the figure, alkyl bromide and sodium azide were used as raw materials, N, N-dimethylformamide was used as solvent, and reacted at room temperature for 20 hours under the protection of nitrogen. After the reaction, the solvent was extracted, dried, filtered and spin evaporated to obtain alkyl azide compound 1.Put a certain proportion of alkyl azide 1 and alkynyl compound 2 into a round bottom flask, copper powder and copper acetate as catalysts, acetonitrile as solvent, and react at room temperature for 4 hours under the protection of nitrogen. After that, extract, dry, filter and spin the solvent, and purify by thin chromatography to obtain triazole compound 3.

Purification Methods

Crystallise 1,2,4-triazole from EtOH, H2O, EtOAc (m 120.5-121o), or EtOH/*C6H6. The hydrochloride has m 170o, and the picrate has m 163-164o (from H2O or CHCl3). [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986]. [Beilstein 26 H 13, 26 II 6, 26 III/IV 35.]

1,2,4-Triazole Preparation Products And Raw materials

Raw materials

1,2-Diformylhydrazine Hydrazinium hydroxide solution 4-Chlorobenzaldehyde Ammonium formate Formic acid Hydrazine hydrate Methyl formate Ammonia

Preparation Products

Propiconazole BASIC RED 46 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 3,5-DIBROMO-1H-1,2,4-TRIAZOLE Anastrozole 1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE Fluconazole Triapenthenol 3-[(2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazol-3-ylidene)hydrazono]-1-methyl-2-phenyl-3H-indolium chloride Paclobutrazol Basic Red 22 Bitertanol

Less

1,2,4-Triazole Suppliers

Austria 3 Belgium 1 Brazil 1 Canada 2 Chile 1 China 651 China Hong Kong 1 Egypt 1 Europe 5 France 4 Germany 18 India 98 Indonesia 1 Italy 1 Japan 9 Poland 1 Russia 1 Singapore 1 Slovakia 1 South Korea 3 Switzerland 8 The Netherlands 1 Ukraine 3 United Arab Emirates 1 United Kingdom 15 United States 86 USA 1 Global 919

Sichuan Hainuowei Technology Co. Ltd.

Tel: 13708085536
Fax: QQ : 121102042
Email: hanovichem@163.com
Country: China
ProdList: 3383
Advantage: 56

hunan solar chemical co.,ltd

Tel: 15725901680
Email: coco@solarchem.cn
Country: China
ProdList: 9
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Shanghai LanRun Chemical Co., Ltd.

Tel: 021-69515658 ; 69515628 13701998368
Fax: 021-69515998
Email: longrunchem@163.com
Country: China
ProdList: 3912
Advantage: 50

Wuhan WinYuanBei Trading Company

Tel: 86-13349903920; 13349903920
Fax: -
Email: 869523959@qq.com
Country: China
ProdList: 9958
Advantage: 58

Wuwei Hailun New Material Technology Co., Ltd.

Tel: 935-5322366 18857389309
Email: sales@hailunchem.com
Country: China
ProdList: 7
Advantage: 58

Weifang Yuan Ye Biotechnology Co., Ltd.

Tel: 0536-5316600 15684478666
Fax: 0536-5396089
Email: shan@yuanyechemical.com
Country: China
ProdList: 41
Advantage: 58

Springchem New Material Technology Co.,Ltd

Tel: 021-52836897 13917661608
Email: info@spring-chem.com
Country: China
ProdList: 1967
Advantage: 58

HIGH HOPE INTERNATIONAL GROUP JIANGSU MEDICINES AND HEALTH PRODUCTS IMPORT AND EXPORT CORPORATION

Tel: 025-84691373 15312418043
Email: yxq@mehecojs.com
Country: China
ProdList: 117
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
Fax: 010-60270825
Email: elainezt@sina.com
Country: China
ProdList: 1390
Advantage: 62

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Taizhou Chemedir Biopharm-tech. Co., Ltd

Tel: 0523-86200218 18994667082
Fax: +86 523-86200613
Email: sale1_cmd@chemedir.com
Country: China
ProdList: 58
Advantage: 64

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9510
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19183
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8835
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Tangshan Moneide Trading Co., Ltd.

Tel: 0315-8309571 15633399667
Fax: +86-315-7726572
Email: sales@moneidechem.com
Country: China
ProdList: 704
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4554
Advantage: 62

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Springchem New Material Technology Co.,Limited

Tel: +86-021-62885108 +8613917661608
Email: info@spring-chem.com
Country: China
ProdList: 2068
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3203
Advantage: 55

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

Tel: 0523-82837785 13914525028
Fax: 0523-87913272
Email: info@jszchg.com
Country: China
ProdList: 249
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
Advantage: 50

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Less

View Lastest Price from 1,2,4-Triazole manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1, 2, 4-Triazole 288-88-0
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1,2,4-Triazole 288-88-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

Shandong shuolan chemical co.ltd

Product: 1H-1,2, 4-triazole 288-88-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: *99%or96%
Supply Ability: 150000
Release date: 2023-06-16

288-88-0, 1,2,4-TriazoleRelated Search:

1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Tolyltriazole 5-Methyl-1H-benzotriazole 1H-1,2,4-Triazole-3-thiol 1-Hydroxybenzotriazole hydrate 3-Amino-1,2,4-Triazole 1H-Benzotriazole 4-Amino-4H-1,2,4-triazole 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 Voriconazole (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Chloro-2',4'-difluoroacetophenone Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI) (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 1-Butanesulfonic acid, 4-hydroxy-, methyl ester Voriconazole Impurity 16

TA-4

PYRRODIAZOLE

TRIAZOLE

TRIAZOLE(1,2,4-)

1H-1,2,4-TRIAZOLE

1-HYDRO-1,2,4-TRIAZOLE

1,2,4-1H-TRIAZOLE

4H-1,2,4-triazole

CGA-71019

s-Triazole

1,2,4-TRIAZOLE, 1GM, NEAT

1,2,4-TriazoleForSynthesis

1,2,4-Triazole,99%

1,2,4-1H-Triazole, 99.50%

1,2,4-1H-Triazole, flakes, 99+%

AKOS BBS-00004410

pyrrodiazol

1H-1,2,4-TRIAZLOENA-1,2,4-TRIAZLOE K-1,2,4-TRIAZLO

1H-1,2,4-Triazole (1,2,4-1H-Triazole

sym-triazole

1,2,4-TRIAZOLE pure

Voriconazole Impurity 7

1H-1,2,4-Triazole≥ 99% (HPLC)

1,2,4-1H-Triazole s-Triazole Pyrrodiazole 1H-1,2,4-Triazole

1,2,4-Triazol

1,2,4-1H-TRIAZOLE, 99+%, FLAKES

1,2,4-1H-TRIAZOLE, 99.5%

1,2,4-1H-Triazole, flakes

1H-1,2,4-Triazol

1.2.4-Triazole 1g [288-88-0]

Triazole-[13C2,15N2]

1,2,4-Triazole

4-1H-Triazole

1,2,4-1H-Triazole, 99.5% 25GR

1,2,4-1H-Triazole, 99.5% 5GR

3,4-Diazapyrrole

s-Triazole (8CI)

1,2,4- threetriazole

1,2,4-1H-Triazole, 99.5%, 99.5%

1, 4-trichlorobenzene three azole nitrogen

Anti-TAAR6 antibody produced in rabbit

TAAR6

TAR4

TaR-4

TAR6

TaR-6

1,2,4-Triazole Vetec(TM) reagent grade, 98%

1,2,4-1H-TriazoL

Fluconazole Impurity 16

1,2,4-Triazole &gt

1,2,4-Triazole, 99%, reagent grade

1,2,4-Triazole @100 μg/mL in MeOH

1,2,4-TRIAZOLE FOR SYNTHESIS 25 G

1, 4-trichlorobenzene triazole

1,2,4-Triazole USP/EP/BP

1,2,4 Triazole LR

1,2,4-Triazole 95% 99%

1H-1,2,4-Triazole (Efinaconazole Impurity)