1,2,4-Triazole

ChemicalBook > CAS DataBase List > 1,2,4-Triazole

Product Name: 1,2,4-Triazole
CAS No.: 288-88-0
Chemical Name: 1,2,4-Triazole
Synonyms: TRIAZOLE;1H-1,2,4-TRIAZOLE;4H-1,2,4-triazole;1,2,4-1H-TRIAZOLE;1,2,4-Triazol;PYRRODIAZOLE;1H-1,2,4-Triazol;1,2,4-Triazole,99%;TA-4;TAR4
CBNumber: CB2277901
Molecular Formula: C2H3N3
Formula Weight: 69.07
MOL File: 288-88-0.mol

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1,2,4-Triazole Property

Melting point:: 119-121 °C (lit.)
Boiling point:: 260 °C (lit.)
Density: 1.15 g/cm3 (130℃)
vapor pressure: 0.215Pa at 20℃
refractive index: 1.4854 (estimate)
Flash point:: 140 °C
storage temp.: Store below +30°C.
solubility: 547g/l
form: Crystalline Powder and Flakes
pka: 2.27(at 20℃)
color: White
PH: 8 (10g/l, H2O, 20℃)
Water Solubility: 1250 g/L (20 ºC)
Merck: 14,9605
BRN: 104767
InChIKey: NSPMIYGKQJPBQR-UHFFFAOYSA-N
LogP: -0.76 at 25℃
CAS DataBase Reference: 288-88-0(CAS DataBase Reference)
NIST Chemistry Reference: 1H-1,2,4-Triazole(288-88-0)
EPA Substance Registry System: 1,2,4-Triazole (288-88-0)

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Safety

Hazard Codes: Xn,Xi,C
Risk Statements: 22-36-63-34
Safety Statements: 36/37-45-36/37/39-27-26
WGK Germany: 2
RTECS: XZ3806000
Hazard Note: Irritant
TSCA: Yes
HS Code: 29339990
Hazardous Substances Data: 288-88-0(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: 1650 mg/kg LD50 dermal Rabbit 3129 - 4200 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T46108
Product name: 1,2,4-Triazole
Purity: 98%
Packaging: 25g
Price: $36.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: T46108
Product name: 1,2,4-Triazole
Purity: 98%
Packaging: 100g
Price: $97.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08388
Product name: 1,2,4-Triazole
Purity: for synthesis
Packaging: 25g
Price: $52.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08388
Product name: 1,2,4-Triazole
Purity: for synthesis
Packaging: 100g
Price: $167
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.08388
Product name: 1,2,4-Triazole
Purity: for synthesis
Packaging: 25kg
Price: $1520
Updated: 2024/03/01

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1,2,4-Triazole Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder and flakes

Uses

1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959.

Uses

1,2,4-Triazole is used in the production of pesticides, pharmaceuticals (fluconazole), dyes and rubber additives, and also in the photoconductor of replication system. Intermediate of antifungal fluconazole.

Uses

1,2,4-triazole and its derivatives are important structural moieties of many pharmaceutical drugs. Triazoles can also act as ligands to form coordination complexes with transition metal ions. Due to their electron-deficient nature, they exhibit excellent electron-transport and hole-blocking properties, making them promising organic materials in material science applications.

Definition

1,2,4-triazole is a chemical substance with molecular formula C2H3N3, molecular weight 69.07 and CAS No. 288-88-0. Colorless acicular crystal, soluble in water and ethanol. 1H-1,2,4-triazole is a 1,2,4-triazole. It is a tautomer of a 3H-1,2,4-triazole and a 4H-1,2,4-triazole.
Triazole is an aromatic five membered heterocyclic compound. Its unique structure is conducive to the formation of a variety of non covalent bonds and is easy to promote the binding of proteins, enzymes and receptors, thus showing a wide range of biological pharmacological activities, such as anticancer, antispasmodic, antibacterial, anti HIV. In particular, 1,2,3-triazole has strong thermal stability and acid-base stability, and is not sensitive to redox, hydrolysis and enzymatic degradation. It is often used as a pharmacodynamic group in drug synthesis.

Definition

A heterocyclic organic compound with a five-membered ring containing two carbon atoms and three nitrogen atoms. There are two isomers.

Flammability and Explosibility

Non flammable

Synthesis

Alkyl bromide and sodium azide were used as raw materials to prepare organic azides, and a series of 1,2,4-Triazole small molecules were prepared by click chemistry. The structures of the six products were characterized by 1H NMR, 13C NMR and IR. the products were expected targets. Furthermore, the effect of different substituent structure on the reaction was discussed. Especially the introduction of drug molecule ethisterone, which is expected to provide a certain experimental basis for the application of triazole and its derivatives in biomedicine and other fields.
As shown in the figure, alkyl bromide and sodium azide were used as raw materials, N, N-dimethylformamide was used as solvent, and reacted at room temperature for 20 hours under the protection of nitrogen. After the reaction, the solvent was extracted, dried, filtered and spin evaporated to obtain alkyl azide compound 1.Put a certain proportion of alkyl azide 1 and alkynyl compound 2 into a round bottom flask, copper powder and copper acetate as catalysts, acetonitrile as solvent, and react at room temperature for 4 hours under the protection of nitrogen. After that, extract, dry, filter and spin the solvent, and purify by thin chromatography to obtain triazole compound 3.

Purification Methods

Crystallise 1,2,4-triazole from EtOH, H2O, EtOAc (m 120.5-121o), or EtOH/*C6H6. The hydrochloride has m 170o, and the picrate has m 163-164o (from H2O or CHCl3). [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986]. [Beilstein 26 H 13, 26 II 6, 26 III/IV 35.]

1,2,4-Triazole Preparation Products And Raw materials

Raw materials

1,2-Diformylhydrazine Hydrazinium hydroxide solution 4-Chlorobenzaldehyde Ammonium formate Formic acid Hydrazine hydrate Methyl formate Ammonia

Preparation Products

Propiconazole BASIC RED 46 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 3,5-DIBROMO-1H-1,2,4-TRIAZOLE Anastrozole 1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE Fluconazole Triapenthenol 3-[(2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazol-3-ylidene)hydrazono]-1-methyl-2-phenyl-3H-indolium chloride Paclobutrazol Basic Red 22 Bitertanol

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View Lastest Price from 1,2,4-Triazole manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: 1,2,4-Triazole 288-88-0
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200000kg
Release date: 2024-04-25

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 1,2,4-Triazole 288-88-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20000tons
Release date: 2024-01-07

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: 1H-1,2,4-Triazole 288-88-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-07

288-88-0, 1,2,4-TriazoleRelated Search:

1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Tolyltriazole 5-Methyl-1H-benzotriazole 1H-1,2,4-Triazole-3-thiol 1-Hydroxybenzotriazole hydrate 3-Amino-1,2,4-Triazole 1H-Benzotriazole 4-Amino-4H-1,2,4-triazole 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 Voriconazole (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Chloro-2',4'-difluoroacetophenone Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- Pyrimidine, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis[2,6-dichloro-5-fluoro- (9CI) (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 1-Butanesulfonic acid, 4-hydroxy-, methyl ester Voriconazole Impurity 16

TA-4

PYRRODIAZOLE

TRIAZOLE

TRIAZOLE(1,2,4-)

1H-1,2,4-TRIAZOLE

1-HYDRO-1,2,4-TRIAZOLE

1,2,4-1H-TRIAZOLE

4H-1,2,4-triazole

CGA-71019

s-Triazole

1,2,4-TRIAZOLE, 1GM, NEAT

1,2,4-TriazoleForSynthesis

1,2,4-Triazole,99%

1,2,4-1H-Triazole, 99.50%

1,2,4-1H-Triazole, flakes, 99+%

AKOS BBS-00004410

pyrrodiazol

1H-1,2,4-TRIAZLOENA-1,2,4-TRIAZLOE K-1,2,4-TRIAZLO

1H-1,2,4-Triazole (1,2,4-1H-Triazole

sym-triazole

1,2,4-TRIAZOLE pure

Voriconazole Impurity 7

1H-1,2,4-Triazole≥ 99% (HPLC)

1,2,4-1H-Triazole s-Triazole Pyrrodiazole 1H-1,2,4-Triazole

1,2,4-Triazol

1,2,4-1H-TRIAZOLE, 99+%, FLAKES

1,2,4-1H-TRIAZOLE, 99.5%

1,2,4-1H-Triazole, flakes

1H-1,2,4-Triazol

1.2.4-Triazole 1g [288-88-0]

Triazole-[13C2,15N2]

1,2,4-Triazole

4-1H-Triazole

1,2,4-1H-Triazole, 99.5% 25GR

1,2,4-1H-Triazole, 99.5% 5GR

3,4-Diazapyrrole

s-Triazole (8CI)

1,2,4- threetriazole

1,2,4-1H-Triazole, 99.5%, 99.5%

1, 4-trichlorobenzene three azole nitrogen

Anti-TAAR6 antibody produced in rabbit

TAAR6

TAR4

TaR-4

TAR6

TaR-6

1,2,4-Triazole Vetec(TM) reagent grade, 98%

1,2,4-1H-TriazoL

Fluconazole Impurity 16

1,2,4-Triazole &gt

1,2,4-Triazole, 99%, reagent grade

1,2,4-Triazole @100 μg/mL in MeOH

1,2,4-TRIAZOLE FOR SYNTHESIS 25 G

1, 4-trichlorobenzene triazole

1,2,4-Triazole USP/EP/BP

1,2,4 Triazole LR

1,2,4-Triazole 95% 99%

1H-1,2,4-Triazole (Efinaconazole Impurity)