ChemicalBook > CAS DataBase List > Phenformin hydrochloride

Phenformin hydrochloride

Product Name
Phenformin hydrochloride
CAS No.
834-28-6
Chemical Name
Phenformin hydrochloride
Synonyms
1-Phen;dbi-td;Insora;meltrol;usafvi-6;Glucopostin;PHENFORMIN HCL;Phenformine HCL;PhenforMin HCl API;phenforminhclno.9113
CBNumber
CB2280910
Molecular Formula
C10H16ClN5
Formula Weight
241.72
MOL File
834-28-6.mol
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Phenformin hydrochloride Property

Melting point:
175-178°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Methanol (Slightly), Water (Slightly)
color 
White to Off-White
Water Solubility 
>=10 g/100 mL at 21 ºC
CAS DataBase Reference
834-28-6(CAS DataBase Reference)
EPA Substance Registry System
Phenformin hydrochloride (834-28-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
DU2200000
HS Code 
29252900
Toxicity
LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7045
Product name
Phenformin hydrochloride
Purity
analytical standard
Packaging
1g
Price
$25.9
Updated
2024/03/01
Sigma-Aldrich
Product number
P7045
Product name
Phenformin hydrochloride
Purity
analytical standard
Packaging
10g
Price
$104
Updated
2024/03/01
Cayman Chemical
Product number
14997
Product name
Phenformin (hydrochloride)
Purity
≥98%
Packaging
10g
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
14997
Product name
Phenformin (hydrochloride)
Purity
≥98%
Packaging
50g
Price
$99
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1573
Product name
Phenformin hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$128
Updated
2024/03/01
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Phenformin hydrochloride Chemical Properties,Usage,Production

Description

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.

Chemical Properties

White Crystalline Solid

Uses

erectile dysfunction therapy

Uses

It is an anti-diabetic drug from the biguanide class.

brand name

DBI (Ciba-Geigy).

General Description

White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.

Air & Water Reactions

Water soluble.

Reactivity Profile

Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Phenformin hydrochloride Preparation Products And Raw materials

Raw materials

Dicyandiamide

Preparation Products

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Phenformin hydrochloride Suppliers

Canada 1 China 194 Germany 1 India 3 Switzerland 1 United Kingdom 7 United States 29 Global 236
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View Lastest Price from Phenformin hydrochloride manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Phenformin hydrochloride 834-28-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2023-02-17
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Phenformin (hydrochloride) 834-28-6
Price
US $99.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Phenformin (hydrochloride) 834-28-6
Price
US $15.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000tons
Release date
2022-01-05

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