Phenformin hydrochloride

Product Name: Phenformin hydrochloride
CAS No.: 834-28-6
Chemical Name: Phenformin hydrochloride
Synonyms: 1-Phen;dbi-td;Insora;meltrol;usafvi-6;Glucopostin;PHENFORMIN HCL;Phenformine HCL;PhenforMin HCl API;phenforminhclno.9113
CBNumber: CB2280910
Molecular Formula: C10H16ClN5
Formula Weight: 241.72
MOL File: 834-28-6.mol

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Phenformin hydrochloride Property

Melting point:: 175-178°C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Water Solubility: >=10 g/100 mL at 21 ºC
CAS DataBase Reference: 834-28-6(CAS DataBase Reference)
EPA Substance Registry System: Phenformin hydrochloride (834-28-6)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: DU2200000
HS Code: 29252900
Toxicity: LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7045
Product name: Phenformin hydrochloride
Purity: analytical standard
Packaging: 1g
Price: $25.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: P7045
Product name: Phenformin hydrochloride
Purity: analytical standard
Packaging: 10g
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 14997
Product name: Phenformin (hydrochloride)
Purity: ≥98%
Packaging: 10g
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 14997
Product name: Phenformin (hydrochloride)
Purity: ≥98%
Packaging: 50g
Price: $99
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1573
Product name: Phenformin hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $128
Updated: 2024/03/01

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Phenformin hydrochloride Chemical Properties,Usage,Production

Description

Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice.

Chemical Properties

White Crystalline Solid

Uses

erectile dysfunction therapy

Uses

It is an anti-diabetic drug from the biguanide class.

brand name

DBI (Ciba-Geigy).

General Description

White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis.

Air & Water Reactions

Water soluble.

Reactivity Profile

Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Phenformin hydrochloride Preparation Products And Raw materials

Raw materials

Dicyandiamide

Preparation Products

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Phenformin hydrochloride Suppliers

Canada 1 China 191 Germany 1 India 3 Switzerland 1 United Kingdom 7 United States 28 Global 232

Renhetang Pharmaceutical Co., Ltd.

Tel: 0539-5253218
Email: rhtyy2008@126.com
Country: China
ProdList: 19
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8843
Advantage: 52

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

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View Lastest Price from Phenformin hydrochloride manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Phenformin hydrochloride 834-28-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2023-02-17

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Phenformin (hydrochloride) 834-28-6
Price: US $99.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1 ton
Release date: 2021-12-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Phenformin (hydrochloride) 834-28-6
Price: US $15.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000tons
Release date: 2022-01-05

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24172

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