ChemicalBook > CAS DataBase List > 2,4'-Difluorobenzophenone

2,4'-Difluorobenzophenone

Product Name
2,4'-Difluorobenzophenone
CAS No.
342-25-6
Chemical Name
2,4'-Difluorobenzophenone
Synonyms
Peucedani Radix。;Peucedani Extract;Procoryza extract;Peucedanum extract;2,4'-Difluorobenzoph;LABOTEST-BB LT00159745;Flutriafol benzophenone;Flunarizine Impurity 22;2,4''-FLUOROBENZOPHENONE;2,4'-Difluorobenzophenone
CBNumber
CB2284817
Molecular Formula
C13H8F2O
Formula Weight
218.2
MOL File
342-25-6.mol
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2,4'-Difluorobenzophenone Property

Melting point:
22-24 °C(lit.)
Boiling point:
176-178 °C16 mm Hg(lit.)
Density 
1.244 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5689(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol
form 
Solid
color 
Off-White
Specific Gravity
1.244
FreezingPoint 
22.0 to 28.0 ℃
BRN 
3268520
InChI
InChI=1S/C13H8F2O/c14-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)15/h1-8H
InChIKey
LKFIWRPOVFNPKR-UHFFFAOYSA-N
SMILES
C(C1=CC=CC=C1F)(C1=CC=C(F)C=C1)=O
CAS DataBase Reference
342-25-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/38
Safety Statements 
26-37/39-24/25-37-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D1796
Product name
2,4'-Difluorobenzophenone
Purity
>96.0%(GC)
Packaging
5g
Price
$78
Updated
2025/07/31
TCI Chemical
Product number
D1796
Product name
2,4'-Difluorobenzophenone
Purity
>96.0%(GC)
Packaging
25g
Price
$166
Updated
2025/07/31
TRC
Product number
D445470
Product name
2,4’-Difluorobenzophenone
Packaging
10g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD62649
Product name
2,4'-Difluorobenzophenone
Packaging
500g
Price
$117.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD62649
Product name
2,4'-Difluorobenzophenone
Packaging
1kg
Price
$188
Updated
2021/12/16
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2,4'-Difluorobenzophenone Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid after melting

Uses

2,4’-Difluorobenzophenone is a reactant in the synthesis of EP1 receptor antagonists for the treatment of overactive bladder. Also used in the design and synthesis of thiosemicarbazone cathespin L inhibitors.

Synthesis

352-13-6

393-52-2

342-25-6

The general procedure for the synthesis of (2-fluorophenyl)(4-fluorophenyl)methanone from 4-fluorophenylmagnesium bromide and o-fluorobenzoyl chloride was as follows: 2-fluorobenzoyl chloride (6 mmol, 1.0 eq.) was dissolved in 2-methyltetrahydrofuran (15 mL) and transported through the material channel A and the metering pump P1; meanwhile, 4-fluorophenylmagnesium bromide (9 mmol, 1.5 eq.) was dissolved in 2- methyltetrahydrofuran (15 mL), delivered through material channel B and metering pump P2. The two solutions were mixed in the mixing module M at a preset temperature of 25 °C and a flow rate of 1 mL/min, and then entered into the reaction module L for 1 hour. Upon completion of the reaction, the reaction solution flowed out of outlet D and was collected in 1 mol/L hydrochloric acid solution for quenching. The quenched solution was stirred, washed with saturated brine solution, dried with anhydrous sodium sulfate, concentrated and purified by column chromatography to afford the target product (2-fluorophenyl)(4-fluorophenyl)methanone.

References

[1] Patent: CN108409516, 2018, A. Location in patent: Paragraph 0049-0052
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 662

2,4'-Difluorobenzophenone Preparation Products And Raw materials

Raw materials

2-Fluorobenzoyl chloride Fluorobenzene Aluminum chloride 2,4-Difluorobenzophenone

Preparation Products

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2,4'-Difluorobenzophenone Suppliers

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View Lastest Price from 2,4'-Difluorobenzophenone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,4'-Difluorobenzophenone 342-25-6
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-30
Hebei Chuanghai Biotechnology Co., Ltd
Product
2,4'-Difluorobenzophenone 342-25-6
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Henan Aochuang Chemical Co.,Ltd.
Product
2,4'-Difluorobenzophenone 342-25-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-12

342-25-6, 2,4'-DifluorobenzophenoneRelated Search:

Difloxacin 2,4-Dihydroxybenzophenone 4,4'-Dihydroxybenzophenone 4,4'-Dimethylbenzophenone Benzophenone 4-Chlorobenzophenone (3,4-Diaminophenyl)phenylmethanone 3,4-Dihydroxybenzophenone 2'-Fluoroacetophenone Difluorochloromethane 4-Fluorobenzaldehyde Benzaldehyde 4-Fluoroacetophenone 1-ETHYL-4-FLUOROBENZENE 4-Fluorobenzophenone difluoroethane Polyvinylenedifluoride p,p'-Difluorobenzophenone,p,p’-difluorobenzophenon

  • LABOTEST-BB LT00159745
  • 2,4"-DIFLUEOROBENZOPHENONE
  • 2,4''-FLUOROBENZOPHENONE
  • (2-fluorophenyl)(4-fluorophenyl)methanone
  • Methanone, (2-fluorophenyl)(4-fluorophenyl)-
  • 2-Fluorophenyl(4-fluorophenyl) ketone
  • 2,4'-Difluorobenzophenone,98%
  • 2,4'-Difluorobenzoph
  • Peucedani Extract
  • 2,4'-Difluorobenzophenone
  • Flutriafol benzophenone
  • 2,4'- twofluorine twoBenzophenone
  • Peucedani Radix。
  • Peucedanum extract
  • 2,4'-Difluorobenzophenone&gt
  • Procoryza extract
  • Peucedanum praeruptorum extract
  • Methoprene Impurity 14 (S-Hydroprene)
  • Flunarizine Impurity 22
  • 2,4′-Difluorobenzophenone, CAS 342-25-6
  • 2,4’-i fluorobenzophenone
  • 342-25-6
  • Reagent for High-Performance Polymer Research
  • Benzophenones (for High-Performance Polymer Research)
  • Aromatic Benzophenones & Derivatives (substituted)
  • Acetophenone Series
  • Benzophenones (for High-Performance Polymer Research)
  • Functional Materials
  • Reagent for High-Performance Polymer Research