2,4'-Difluorobenzophenone
- Product Name
- 2,4'-Difluorobenzophenone
- CAS No.
- 342-25-6
- Chemical Name
- 2,4'-Difluorobenzophenone
- Synonyms
- Peucedani Radix。;Peucedani Extract;Procoryza extract;Peucedanum extract;2,4'-Difluorobenzoph;LABOTEST-BB LT00159745;Flutriafol benzophenone;Flunarizine Impurity 22;2,4''-FLUOROBENZOPHENONE;2,4'-Difluorobenzophenone
- CBNumber
- CB2284817
- Molecular Formula
- C13H8F2O
- Formula Weight
- 218.2
- MOL File
- 342-25-6.mol
2,4'-Difluorobenzophenone Property
- Melting point:
- 22-24 °C(lit.)
- Boiling point:
- 176-178 °C16 mm Hg(lit.)
- Density
- 1.244 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5689(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- color
- Off-White
- Specific Gravity
- 1.244
- FreezingPoint
- 22.0 to 28.0 ℃
- BRN
- 3268520
- InChI
- InChI=1S/C13H8F2O/c14-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)15/h1-8H
- InChIKey
- LKFIWRPOVFNPKR-UHFFFAOYSA-N
- SMILES
- C(C1=CC=CC=C1F)(C1=CC=C(F)C=C1)=O
- CAS DataBase Reference
- 342-25-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36/38
- Safety Statements
- 26-37/39-24/25-37-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D1796
- Product name
- 2,4'-Difluorobenzophenone
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- D1796
- Product name
- 2,4'-Difluorobenzophenone
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $166
- Updated
- 2025/07/31
- Product number
- D445470
- Product name
- 2,4’-Difluorobenzophenone
- Packaging
- 10g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 004784
- Product name
- 2,4'-Difluorobenzophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 006466
- Product name
- 2,4'-Difluorobenzophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $14
- Updated
- 2021/12/16
2,4'-Difluorobenzophenone Chemical Properties,Usage,Production
Chemical Properties
clear light yellow liquid after melting
Uses
2,4’-Difluorobenzophenone is a reactant in the synthesis of EP1 receptor antagonists for the treatment of overactive bladder. Also used in the design and synthesis of thiosemicarbazone cathespin L inhibitors.
Synthesis
352-13-6
393-52-2
342-25-6
The general procedure for the synthesis of (2-fluorophenyl)(4-fluorophenyl)methanone from 4-fluorophenylmagnesium bromide and o-fluorobenzoyl chloride was as follows: 2-fluorobenzoyl chloride (6 mmol, 1.0 eq.) was dissolved in 2-methyltetrahydrofuran (15 mL) and transported through the material channel A and the metering pump P1; meanwhile, 4-fluorophenylmagnesium bromide (9 mmol, 1.5 eq.) was dissolved in 2- methyltetrahydrofuran (15 mL), delivered through material channel B and metering pump P2. The two solutions were mixed in the mixing module M at a preset temperature of 25 °C and a flow rate of 1 mL/min, and then entered into the reaction module L for 1 hour. Upon completion of the reaction, the reaction solution flowed out of outlet D and was collected in 1 mol/L hydrochloric acid solution for quenching. The quenched solution was stirred, washed with saturated brine solution, dried with anhydrous sodium sulfate, concentrated and purified by column chromatography to afford the target product (2-fluorophenyl)(4-fluorophenyl)methanone.
References
[1] Patent: CN108409516, 2018, A. Location in patent: Paragraph 0049-0052
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 662
2,4'-Difluorobenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2,4'-Difluorobenzophenone Suppliers
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View Lastest Price from 2,4'-Difluorobenzophenone manufacturers
- Product
- 2,4'-Difluorobenzophenone 342-25-6
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-30
- Product
- 2,4'-Difluorobenzophenone 342-25-6
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 2,4'-Difluorobenzophenone 342-25-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-12