TYRPHOSTIN B7
- Product Name
- TYRPHOSTIN B7
- CAS No.
- 134036-53-6
- Chemical Name
- TYRPHOSTIN B7
- Synonyms
- AG 370;TYRPHOSTIN B7;TYRPHOSTIN AG 370;TYROPHOSTIN AG 370;2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE;2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-;2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
- CBNumber
- CB2288901
- Molecular Formula
- C15H9N5
- Formula Weight
- 259.27
- MOL File
- 134036-53-6.mol
TYRPHOSTIN B7 Property
- Boiling point:
- 714.1±60.0 °C(Predicted)
- Density
- 1.396±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- Yellow solid.
- pka
- 15.95±0.30(Predicted)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 10010568
- Product name
- AG-370
- Purity
- ≥95% (cis/trans mixture)
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 10010568
- Product name
- AG-370
- Purity
- ≥95% (cis/trans mixture)
- Packaging
- 5mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 10010568
- Product name
- AG-370
- Purity
- ≥95% (cis/trans mixture)
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 10010568
- Product name
- AG-370
- Purity
- ≥95% (cis/trans mixture)
- Packaging
- 25mg
- Price
- $957
- Updated
- 2024/03/01
- Product number
- KIN0000514
- Product name
- AG-370
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $460
- Updated
- 2021/12/16
TYRPHOSTIN B7 Chemical Properties,Usage,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-
Definition
ChEBI: AG-370 is a member of indoles.
in vitro
previous study found that ag-370 inhibited pdgf receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the pdgf receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. when compared with ag18, a potent egf receptor blocker, ag370 was more efficient in inhibiting pdgf-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. under the conditions in which ag370 could inhibit pdgf-induced mitogenesis and phosphorylation, ag18 did not alter [125i]pdgf internalization and enhance [125i]pdgf binding. these findings suggested that ag370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by pdgf [1].
IC 50
20 μm for pdgf receptor kinase in human bone marrow fibroblasts
References
[1] bryckaert, m. c.,eldor, a.,fontenay, m., et al. inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. experimental cell research 199, 255-261 (1992).
TYRPHOSTIN B7 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN B7 Suppliers
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