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TYRPHOSTIN B7

Product Name
TYRPHOSTIN B7
CAS No.
134036-53-6
Chemical Name
TYRPHOSTIN B7
Synonyms
AG 370;TYRPHOSTIN B7;TYRPHOSTIN AG 370;TYROPHOSTIN AG 370;2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE;2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-;2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
CBNumber
CB2288901
Molecular Formula
C15H9N5
Formula Weight
259.27
MOL File
134036-53-6.mol
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TYRPHOSTIN B7 Property

Boiling point:
714.1±60.0 °C(Predicted)
Density 
1.396±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Yellow solid.
pka
15.95±0.30(Predicted)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010568
Product name
AG-370
Purity
≥95% (cis/trans mixture)
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
10010568
Product name
AG-370
Purity
≥95% (cis/trans mixture)
Packaging
5mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
10010568
Product name
AG-370
Purity
≥95% (cis/trans mixture)
Packaging
10mg
Price
$437
Updated
2024/03/01
Cayman Chemical
Product number
10010568
Product name
AG-370
Purity
≥95% (cis/trans mixture)
Packaging
25mg
Price
$957
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
KIN0000514
Product name
AG-370
Purity
95.00%
Packaging
1MG
Price
$460
Updated
2021/12/16
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TYRPHOSTIN B7 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 μM).

Definition

ChEBI: AG-370 is a member of indoles.

in vitro

previous study found that ag-370 inhibited pdgf receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the pdgf receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. when compared with ag18, a potent egf receptor blocker, ag370 was more efficient in inhibiting pdgf-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. under the conditions in which ag370 could inhibit pdgf-induced mitogenesis and phosphorylation, ag18 did not alter [125i]pdgf internalization and enhance [125i]pdgf binding. these findings suggested that ag370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by pdgf [1].

IC 50

20 μm for pdgf receptor kinase in human bone marrow fibroblasts

References

[1] bryckaert, m. c.,eldor, a.,fontenay, m., et al. inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. experimental cell research 199, 255-261 (1992).

TYRPHOSTIN B7 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B7 Suppliers

Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

134036-53-6, TYRPHOSTIN B7Related Search:


  • AG 370
  • 2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
  • TYROPHOSTIN AG 370
  • TYRPHOSTIN B7
  • TYRPHOSTIN AG 370
  • 3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE
  • 2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE
  • 2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE
  • 2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-
  • 134036-53-6
  • Platelet Derived Growth Factor Receptor (PDGFR)
  • Receptor Tyrosine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical