2,6-Dibromopyridine

ChemicalBook > CAS DataBase List > 2,6-Dibromopyridine

2,6-Dibromopyridine

Product Name: 2,6-Dibromopyridine
CAS No.: 626-05-1
Chemical Name: 2,6-Dibromopyridine
Synonyms: 2,4-dibroMo-6-nitropyridine;2,6-dibromo-pyridin;2,6-DIBROMOPYRIDINE;Lasmiditan Impurity 46;Pyridine, 2,6-dibromo-;2,6-Dibromopyridine,98%;2,6-Dibromopyridine >2,6-DibroMopyridine, 98% 25GR;2,6-Dibromopyridine CAS 626-05-1;2,6-Dibromopyridine ISO 9001：2015 REACH
CBNumber: CB2299002
Molecular Formula: C5H3Br2N
Formula Weight: 236.89
MOL File: 626-05-1.mol

Less

2,6-Dibromopyridine Property

Melting point:: 117-119 °C (lit.)
Boiling point:: 255°C
Density: 2.0383 (rough estimate)
refractive index: 1.5800 (estimate)
Flash point:: 213 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: -3.65±0.10(Predicted)
form: Crystalline Powder
color: White to gray or buff
Water Solubility: insoluble
BRN: 108922
InChI: InChI=1S/C5H3Br2N/c6-4-2-1-3-5(7)8-4/h1-3H
InChIKey: FEYDZHNIIMENOB-UHFFFAOYSA-N
SMILES: C1(Br)=NC(Br)=CC=C1
CAS DataBase Reference: 626-05-1(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,T,T+
Risk Statements: 36/37/38-25-20/21-52-28-52/53-36/38
Safety Statements: 26-37/39-45-36/37/39-36-36/37-28-61
RIDADR: 2811
WGK Germany: 3
RTECS: US7883000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: II
HS Code: 29333999

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D43115
Product name: 2,6-Dibromopyridine
Purity: 98%
Packaging: 25g
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: D43115
Product name: 2,6-Dibromopyridine
Purity: 98%
Packaging: 100g
Price: $208
Updated: 2024/03/01

TCI Chemical

Product number: D1555
Product name: 2,6-Dibromopyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: D1555
Product name: 2,6-Dibromopyridine
Purity: >98.0%(GC)
Packaging: 250g
Price: $230
Updated: 2024/03/01

Alfa Aesar

Product number: A15397
Product name: 2,6-Dibromopyridine, 98%
Packaging: 25g
Price: $72.6
Updated: 2024/03/01

Less

2,6-Dibromopyridine Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystalline powder

Uses

2,6-Dibromopyridine is used as a tridentate chelating ligand and in the formation of macrocycles containing the terpyridine moiety. It is also used to produce 6-bromo-2-methoxypyridine.

Application

2,6-Dibromopyridine is an important organic chemical reagent with a wide range of uses:
(1) Spectroscopic studies: There is a satisfactory correlation between the normal Raman spectra of 2,6-dibromopyridine in aqueous solution and the surface enhanced Raman (SER) spectra in silver-pure sols. In the SER spectra, the compounds are notable for the stretching of the vibrational modes of (py)CBr and (CC,CN)(py) in 2,6-dibromopyridine to give enhanced vibrational intensities at 1175 and 1369 cm-1 , respectively^[1].
(2) Reaction reagent: Friedel–Crafts-type acylation of alkenes with acyl chlorides has been successfully conducted with a wide substrate scope by the combined use of AlCl3 and 2,6-dibromopyridine. Trisubstituted alkenes afford allylketones or vinylketones depending on the presence or absence of hydrogen atom(s) at the β-position to the acylation site, while monosubstituted alkenes exclusively afford vinylketones^[2]. In addition, 2,6-Dibromopyridine can be brominated to form 2,4,6-tribromopyridine by reacting with a mixture of bromine at 450~ 550 °C^[3]. It can also be lithiated with butyl lithium for the synthesis of L-739,010^[4].
(3) A selective palladium-catalysed arylation of 2,6-dibromopyridine has been developed by employing N-heterocyclic carbene ligands. Selective mono-arylation was performed in water/acetonitrile solvent system at ambient temperature with catalyst loading of 0.1 mol%. This reaction was also found to proceed smoothly in water although at a slightly elevated temperature of 80 °C. 2,6-Disubstituted and diversely substituted 2,6-pyridines were also obtained in high yields which will be of importance to organic and medicinal chemists^[5].

Purification Methods

Purify 2,6-dibromopyridine by steam distillation, then recrystallise it twice from EtOH. It does not form an HgCl2 salt. [den Hertog & Wibaut Recl Trav Chim Pays Bas 51 381 1932, Beilstein 20/5 V 435.]

References

[1] S. CHATTOPADHYAY S. K B. Surface-enhanced Raman spectroscopy of 2,5-dibromopyridine and 2,6-dibromopyridine[J]. Spectrochimica acta. Part A: Molecular spectroscopy, 1992. DOI:10.1016/0584-8539(92)80253-S.
[2] SHINYA TANAKA*. Acylation of Alkenes with the Aid of AlCl3 and 2,6-Dibromopyridine[J]. Organic Letters, 2019. DOI:10.1021/acs.orglett.9b02688.
[3] H. J. HERTOG C. R K ;W Combe. Substitution reactions in the pyridine nucleus at elevated temperatures (I). The bromination of 2,6‐dibromopyridine[J]. Recueil des Travaux Chimiques des Pays-Bas, 2010. DOI:10.1002/RECL.19580770109.
[4] D. CAI T. V D Hughes. A study of the lithiation of 2,6-dibromopyridine with butyllithium, and its application to synthesis of L-739,010[J]. Tetrahedron Letters, 1996. DOI:10.1016/0040-4039(96)00336-X.
[5] PRAJAPATI D, SCHULZKE C, KINDERMANN M K, et al. Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands?[J]. RSC Advances, 2015. DOI:10.1039/C5RA10561G.

2,6-Dibromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Bromo-6-methoxypyridine 6-Methoxypyridine-2-carbaldehyde 2-BROMO-6-(1H-PYRAZOL-1-YL)PYRIDINE (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER 2-Amino-6-bromopyridine 6-ETHOXY-2-PYRIDINAMINE 6-Bromopyridine-2-carbaldehyde 6-TERT-BUTOXYPYRIDINE-2-CARBOXALDEHYDE 2-Amino-6-methoxypyridine Acrivastine 2,6-Dihydroxypyridine 4-AMINO-2,6-DIBROMOPYRIDINE

Less

2,6-Dibromopyridine Suppliers

Americas 1 Belgium 3 Canada 1 China 415 Europe 4 France 4 Germany 10 India 55 Ireland 1 Japan 6 Jordan 1 Russia 1 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 22 United States 74 Global 606

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9810
Advantage: 59

Nanjing Chao Yi Biotechnology Co., Ltd.

Tel: 025-52614296 17761738099
Fax: 025-52614296
Email: cychemical@126.com
Country: China
ProdList: 53
Advantage: 55

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5904
Advantage: 65

Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 0531-82375886 13001715031
Fax: 0531-82375893
Email: 3517280075@qq.com
Country: China
ProdList: 1320
Advantage: 58

Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd

Tel: 18072846723; 18072846723
Email: caigou1@witofly.com
Country: China
ProdList: 3127
Advantage: 58

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.

Tel: 0513-82104991 18912868361
Fax: QQ1907456386
Email: sales11@btcpharm.com
Country: China
ProdList: 1334
Advantage: 58

XPERTICK (SHANDONG) BIO-PHARMACEUTICAL CO., LTD

Tel: 21-58999881 15623240527
Email: emily@xtick.cn
Country: China
ProdList: 75
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
Fax: 010-60270825
Email: elainezt@sina.com
Country: China
ProdList: 1390
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376090521
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 966
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8836
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

RYSS TECH LTD

Tel: 400-188-0725 +86 21 34310725 13611771617
Fax: +86 21 34311076
Country: China
ProdList: 2002
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4378
Advantage: 65

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Changzhou Standard Chemicals Ltd.

Tel: 0519-85607885 13776800733
Fax: +86 519 8552788
Email: email@standardschem.com
Country: China
ProdList: 114
Advantage: 62

Explovisual Technology Incorporation

Tel: +86 (519) 8829-2061
Fax: +86 (519) 8829-2061
Email: explovisual@hotmail.com
Country: China
ProdList: 296
Advantage: 60

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3203
Advantage: 55

Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
Country: China
ProdList: 1541
Advantage: 55

Synthetics China Co.,Ltd

Tel: 0512-65218020; 18261037325
Email: ivy.shen@pharmsyn.com
Country: China
ProdList: 101
Advantage: 60

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9458
Advantage: 58

Yurui (Shanghai) Chemical Co., Ltd.

Tel: 02150456736 18602143071
Fax: 021-50761379
Email: Jenny@riyngroup.com
Country: China
ProdList: 908
Advantage: 30

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 18017383231 18017383231
Fax: qq：2817624287
Email: lyh_antaeus@163.com
Country: China
ProdList: 9347
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Ascepion Pharmaceuticals, Inc.

Tel: +86-512-86881668
Fax: +86-512-62956001
Country: China
ProdList: 100
Advantage: 58

Less

View Lastest Price from 2,6-Dibromopyridine manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: 2,6-Dibromopyridine 626-05-1
Price: US $15.00-50.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 5 ton per month
Release date: 2023-04-02

Hebei Weibang Biotechnology Co., Ltd

Product: 2,6-Dibromopyridine 626-05-1
Price: US $19.90/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Honest Joy Holdings Limited

Product: 2,6-Dibromopyridine 626-05-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-02-20

626-05-1, 2,6-DibromopyridineRelated Search:

2,6-Dibromopyridine 2,6-Dibromopyridine oxide 3-Amino-2,6-dibromopyridine ,98% 2,6-Dibromo-3-nitropyridine 1,3-DIBROMOISOQUINOLINE 2,4,6-Tribromopyridine 2,5-DIBROMOPYRIDINE-3-BORONIC ACID 3,5-DIBROMOPYRIDINE 2,3-DIBROMOPYRIDINE,2,3-DIBROMOPYRIDINE 98% 2,6-Dibromopyridine-4-carboxylic acid 3,5-DIBROMOPYRIDINE 1-OXIDE,3,5-DIBROMOPYRIDINE-PYRIDIN 1-OXIDE, 98+% 4-Methyl-3,5-dibromopyridine 3,5-DIBROMO-2-FLUOROPYRIDINE/2-FLUORO-3,5-DIBROMOPYRIDINE 3,5-Dibromopyridine-2(1H)-one 3,5-DIBROMOPYRIDINE-2-CARBOXYLIC ACID 3,5-Dibromopyridine-4-carboxaldehyde 3,4-DIBROMOPYRIDINE 2,6-DIBROMOPYRIDINE-4-CARBOXALDEHYDE

2,6-DIBROMOPYRIDINE

2,6-dibromo-pyridin

2,6-Dibromopyridine,98%

Pyridine, 2,6-dibromo-

2,6-DibroMopyridine, 98% 25GR

2,4-dibroMo-6-nitropyridine

2,6-Dibromopyridine &gt

2,6-Dibromopyridine, 98%, for synthesis

2,6-Dibromopyridine ISO 9001：2015 REACH

2,6-Dibromopyridine CAS 626-05-1

Lasmiditan Impurity 46

626-05-1

626-89-3

626-05-3

625-05-1

626-06-1

C5H3BrN

Building Blocks

Pyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Bromopyridines

Halopyridines

alkyl bromide

Bromopyridines

Halopyridines

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Pyridine

Pyridine Series

Pyridines, Pyrimidines, Purines and Pteredines

bc0001