ChemicalBook > CAS DataBase List > 3-Fluoro-4-methylaniline

3-Fluoro-4-methylaniline

Product Name
3-Fluoro-4-methylaniline
CAS No.
452-77-7
Chemical Name
3-Fluoro-4-methylaniline
Synonyms
3-FLUORO-P-TOLUIDINE;3-fluoro-p-toluidin;3-Fluoro-4-methylani;4-AMINO-2-FLUOROTOLUENE;3-FLUORO-PARA-TOLUIDINE;3-FLUORO-4-METHYLANILINE;2-FLUORO-4-AMINO-TOLUENE;3-Fluoro-4-methylaniline98%;3-Fluoro-4-methylaniline>3-fluoro-4-methyl-benzenamin
CBNumber
CB2301992
Molecular Formula
C7H8FN
Formula Weight
125.14
MOL File
452-77-7.mol
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3-Fluoro-4-methylaniline Property

Melting point:
30-32 °C (lit.)
Boiling point:
93°C 12mm
Density 
1.093 g/mL at 25 °C (lit.)
refractive index 
1.5385-1.5405
Flash point:
88 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to lump to clear liquid
pka
4.02±0.10(Predicted)
Specific Gravity
1.093
color 
Light yellow to Brown
BRN 
2715987
InChI
InChI=1S/C7H8FN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3
InChIKey
MGRHBBRSAFPBIN-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(C)C(F)=C1
CAS DataBase Reference
452-77-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
36/37/38-23/24/25-20/21/22
Safety Statements 
45-36/37/39-26-36/37-36
RIDADR 
2811
WGK Germany 
3
RTECS 
XU6825000
Hazard Note 
Toxic/Irritant
HazardClass 
6.1(b)
PackingGroup 
I
HS Code 
29214300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
222666
Product name
3-Fluoro-4-methylaniline
Purity
99%
Packaging
5g
Price
$23.7
Updated
2023/01/07
Sigma-Aldrich
Product number
222666
Product name
3-Fluoro-4-methylaniline
Purity
99%
Packaging
25g
Price
$82.2
Updated
2023/01/07
TCI Chemical
Product number
F0440
Product name
3-Fluoro-4-methylaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
F0440
Product name
3-Fluoro-4-methylaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$77
Updated
2021/12/16
TRC
Product number
F600098
Product name
3-Fluoro-4-methylaniline
Packaging
5g
Price
$60
Updated
2021/12/16
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3-Fluoro-4-methylaniline Chemical Properties,Usage,Production

Chemical Properties

clear pale yellow to brownish liquid after melting

Characteristics

3-Fluoro-4-methylaniline is an amide and has anti-cancer properties.

Uses

3-Fluoro-4-methylaniline is a synthesized compound that is used to produce anti-cancer agents.

Synthesis

1427-07-2

452-77-7

General procedure for the synthesis of 3-fluoro-4-methylaniline from 2-fluoro-4-nitrotoluene: Freshly distilled toluene (0.6 mL), aromatic nitro compounds (0.60 mmol), indium triiodide (InI3, 14.9 mg, 0.030 mmol) and 1,1,3,3-tetramethyldi siloxane (TMDS, 318 μL, 1.80 mmol). After sealing the vial with a polytetrafluoroethylene (PTFE) septum, the mixture was stirred at 60 °C (bath temperature) and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 5 mL of aqueous sodium bicarbonate (NaHCO3) was added to the mixture, which was then extracted with ethyl acetate (EtOAc, 3 × 6 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: n-hexane-ethyl acetate, from 9:1 to 4:1) to obtain the target product 3-fluoro-4-methylaniline.

References

[1] Tetrahedron Letters, 2003, vol. 44, # 42, p. 7783 - 7787
[2] Synthesis (Germany), 2015, vol. 47, # 20, p. 3179 - 3185
[3] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[4] Monatshefte fuer Chemie, 1959, vol. 90, p. 683,687
[5] Journal of the Chemical Society, 1949, p. Spl. 113

3-Fluoro-4-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-methylaniline Suppliers

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View Lastest Price from 3-Fluoro-4-methylaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-Fluoro-4-methylaniline 452-77-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-01
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Fluoro-4-methylaniline 452-77-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-28
Career Henan Chemical Co
Product
3-Fluoro-4-methylaniline 452-77-7
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

452-77-7, 3-Fluoro-4-methylanilineRelated Search:

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  • Organic Building Blocks
  • Nitrogen Compounds
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  • C7
  • Amines
  • Aryl Fluorinated Building Blocks
  • Building Blocks
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  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Nitrogen Compounds
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  • Aniline
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